A5015370507- Muscle activation and electromyography studies
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Cerebral Palsy and Movement Disorders
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Body Composition Measurement Techniques
- Muscle Physiology and Disorders
- Motor Control and Adaptation
- Sports Performance and Training
- Balance, Gait, and Falls Prevention
- Muscle metabolism and nutrition
- Sports injuries and prevention
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Frailty in Older Adults
- Adipose Tissue and Metabolism
- Physical Activity and Health
- Myofascial pain diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Vestibular and auditory disorders
- Children's Physical and Motor Development
- Dementia and Cognitive Impairment Research
- Lower Extremity Biomechanics and Pathologies
- Health disparities and outcomes
Ohio University
2016-2025
Australian Institute for Musculoskeletal Science
2024
Western Health
2024
The University of Melbourne
2024
The Ohio State University
2023
University of Missouri
2023
Yale University
2020
University of Maryland, Baltimore
2018
University of Maryland Medical Center
2018
East Carolina University
2018
In 2008, we published an article arguing that the age-related loss of muscle strength is only partially explained by reduction in mass and other physiologic factors explain weakness older adults (Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829-834). Accordingly, proposed these events (strength loss) be defined independently, leaving term "sarcopenia" to used its original context describe mass. We subsequently coined "dynapenia" power. This will give...
OBJECTIVES To develop an evidence‐based definition of sarcopenia that can facilitate identification older adults at risk for clinically relevant outcomes (eg, self‐reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition Outcomes Consortium (SDOC) crafted a set position statements informed by literature review SDOC's analyses eight epidemiologic studies, six randomized clinical trials, four cohort studies special populations, two nationally representative...
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
This study evaluated the effect of 4 weeks low-load resistance exercise with blood flow restriction (BFRE) on increasing strength in comparison high-load (HLE), and assessed changes blood, vascular neural function. Healthy adults performed leg extension BFRE or HLE 3 days/week at 30% 80% strength, respectively. During BFRE, a cuff upper was inflated to above systolic pressure. Strength, pulse-wave velocity (PWV), ankle-brachial index (ABI), prothrombin time (PT) nerve conduction (NC) were...
The purposes of this study were 1) to evaluate gender differences in back extensor endurance capacity during isometric and isotonic muscular contractions, 2) determine the relation between absolute load time, 3) compare men [ n = 10, age 22.4 ± 0.69 (SE) yr] women ( 21.7 1.07 yr) terms neuromuscular activation patterns median frequency (MF) shifts electromyogram (EMG) power spectrum lumbar hip muscles fatiguing submaximal trunk extension exercise. Subjects performed exercise failure at 50%...
Resistance training at low loads with blood flow restriction (BFR) (also known as Kaatsu) has been shown to stimulate increases in muscle size and strength. It is unclear how occlusion pressure, exercise intensity, duration interact, or which combination of these factors results the most potent stimulus. Purpose: To determine effect eight BFR protocols on fatigue (decrement maximal voluntary contraction (MVC) after performance exercise), compare decrement MVC currently recommended resistance...
The deterioration of skeletal muscle with advancing age has long been anecdotally recognized and scientific interest for more than 150 years. Over the past several decades, medical communities have that dysfunction (e.g., weakness, poor coordination, etc.) is a debilitating life-threatening condition in elderly. For example, age-associated loss strength highly associated both mortality physical disability. It well-accepted voluntary force production not solely dependent upon size, but rather...
The purpose of this study was to determine whether anodal transcranial direct current stimulation (tDCS) delivered while performing a sustained submaximal contraction would increase time task failure (TTF) compared sham stimulation. Healthy volunteers (n = 18) performed two fatiguing contractions at 20% maximum strength with the elbow flexors on separate occasions. During fatigue performance, either or motor cortex for up 20 minutes. Transcranial magnetic (TMS) used assess changes in...
We tested the hypothesis that nervous system, and cortex in particular, is a critical determinant of muscle strength/weakness high level corticospinal inhibition an important neurophysiological factor regulating force generation. A group healthy individuals underwent 4 wk wrist-hand immobilization to induce weakness. Another also immobilization, but they performed mental imagery strong contractions 5 days/wk. Mental has been shown activate several cortical areas are involved with actual...
In older adults, the loss of muscle strength (dynapenia) and mass (sarcopenia) are important contributors to physical function. We sought investigate dynapenia, sarcopenia, motor unit function in aging mice. C57BL/6J mice were analyzed with cross-sectional (males: 3 vs. 27 months; males females: 8 12 20 months) longitudinal studies 10–25 using vivo electrophysiological measures connectivity (triceps surae compound action potential number estimation), plantar flexion torque, magnetic...