A5017497126- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Pharmacology and Obesity Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Renal and Vascular Pathologies
- Cardiovascular Disease and Adiposity
- Frailty in Older Adults
- Cerebral Palsy and Movement Disorders
- Sexual function and dysfunction studies
- Muscle Physiology and Disorders
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Prostate Cancer Treatment and Research
- Hypothalamic control of reproductive hormones
- Pharmacological Effects and Assays
- Blood Pressure and Hypertension Studies
- HIV-related health complications and treatments
- Obesity, Physical Activity, Diet
- Sexual Differentiation and Disorders
- Doping in Sports
- Cancer, Lipids, and Metabolism
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
McGill University Health Centre
2024
Royal Victoria Hospital
2024
Royal Victoria Regional Health Centre
2024
Function Promoting Therapies (United States)
2017-2024
Woman's Hospital
2019-2022
Men's Health Boston
2016-2022
Hebrew SeniorLife
2020-2021
Beth Israel Deaconess Medical Center
2014-2021
Intima-media thickness of the walls common carotid artery and internal may add to Framingham risk score for predicting cardiovascular events.We measured mean intima-media maximum in 2965 members Offspring Study cohort. Cardiovascular-disease outcomes were evaluated an average follow-up 7.2 years. Multivariable Cox proportional-hazards models generated factors. We reclassification disease on basis 8-year category (low, intermediate, or high) after adding values.A total 296 participants had a...
OBJECTIVES To develop an evidence‐based definition of sarcopenia that can facilitate identification older adults at risk for clinically relevant outcomes (eg, self‐reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition Outcomes Consortium (SDOC) crafted a set position statements informed by literature review SDOC's analyses eight epidemiologic studies, six randomized clinical trials, four cohort studies special populations, two nationally representative...
The discrimination of a risk prediction model measures that model's ability to distinguish between subjects with and without events. area under the receiver operating characteristic curve (AUC) is popular measure discrimination. However, AUC has recently been criticized for its insensitivity in comparisons which baseline performed well. Thus, 2 other have proposed capture improvement nested models: integrated continuous net reclassification improvement. In present study, authors use...
Testosterone use in older men is increasing, but its long-term effects on progression of atherosclerosis are unknown.To determine the effect testosterone administration subclinical with low or low-normal levels.Testosterone's Effects Atherosclerosis Progression Aging Men (TEAAM) was a placebo-controlled, double-blind, parallel-group randomized trial involving 308 60 years levels (100-400 ng/dL; free <50 pg/mL), recruited at 3 US centers. Recruitment took place between September 2004 and...
The cardiovascular safety of testosterone-replacement therapy in middle-aged and older men with hypogonadism has not been determined.In a multicenter, randomized, double-blind, placebo-controlled, noninferiority trial, we enrolled 5246 45 to 80 years age who had preexisting or high risk disease reported symptoms two fasting testosterone levels less than 300 ng per deciliter. Patients were randomly assigned receive daily transdermal 1.62% gel (dose adjusted maintain between 350 750 deciliter)...
Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration a definition sarcopenia. We describe associations between SDOC-identified low (absolute or standardized to body size/composition); dual-energy x-ray absorptiometry (DXA) lean mass as previously defined literature (appendicular [ALM]/ht2 ); slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility...
The effect of testosterone on depressive symptoms in men with hypogonadism remains incompletely understood.
Abstract Background and Aims Despite growing evidence that apolipoprotein B (apoB) is the most accurate marker of atherosclerotic cardiovascular disease (ASCVD) risk, its adoption in clinical practice has been low. This investigation sought to determine whether low-density lipoprotein cholesterol (LDL-C), non–high-density (HDL-C), triglycerides are sufficient for routine care. Methods A sample 293 876 UK Biobank adults (age: 40–73 years, 42% men), free disease, with a median follow-up...
Findings of studies testosterone's effects on muscle strength and physical function in older men have been inconsistent; its power fatigability not studied. To determine the testosterone administration for 3 years strength, power, fatigability, function. This was a double-blind, placebo-controlled, randomized trial healthy ≥60 old with total levels 100 to 400 ng/dL or free <50 pg/mL. Random assignment 7.5 g 1% placebo gel daily years. Loaded unloaded stair-climbing leg press chest exercises,...
Objective. The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common (CCA) IMT as global markers cardiovascular disease (CVD). Methods. Cross-sectional measurements the mean CCA and maximum ICA were made on ultrasound images acquired from Framingham Offspring cohort (n = 3316; age, 58 years; 52.7% women). Linear regression models used associations risk factors IMT. Multivariate logistic receiver operating characteristic (ROC) curve analysis...
Abstract Background Lack of consensus on how to diagnose sarcopenia has limited the ability this condition and hindered drug development. The Sarcopenia Definitions Outcomes Consortium (SDOC) was formed develop evidence-based diagnostic cut points for lean mass and/or muscle strength that identify people at increased risk mobility disability. We describe here proceedings a meeting SDOC other experts discuss strategic considerations in development definition. Methods Presentations panel...
Obesity and type 2 diabetes continue to increase in prevalence the U.S. Whether incidence continues recent times is less well documented. We examined trends over previous four decades.Framingham Heart Study participants ages 40-55 years free of at baseline (n = 4,795; mean age 45.3 years; 51.6% women) were followed for development 1970s, 1980s, 1990s, 2000s. Diabetes was defined as either fasting glucose ≥126 mg/dL or use antidiabetes medication. Poisson regression used calculate...
Background— The presence and extent of coronary artery calcium (CAC) are associated with increased risk for cardiovascular events. We determined whether information on the distribution CAC dominance as detected by cardiac computed tomography were incremental to traditional Agatston score (AS) in predicting incident major heart disease (CHD). Methods Results— assessed total AS per artery, segment, participants from offspring third-generation cohorts Framingham Heart Study. primary outcome was...
<h3>Importance</h3> The Institute of Medicine set the recommended dietary allowance (RDA) for protein at 0.8 g/kg/d entire adult population. It remains controversial whether intake greater than RDA is needed to maintain anabolism in older adults. <h3>Objective</h3> To investigate increasing 1.3 adults with physical function limitations and usual within improves lean body mass (LBM), muscle performance, function, fatigue, well-being augments LBM response a anabolic drug. <h3>Design, Setting,...
Declining physical activity commonly occurs in people with Parkinson disease (PD) and contributes to reduced functional capacity quality of life.The purpose this study was explore the preliminary effectiveness, safety, acceptability a mobile health (mHealth)-mediated exercise program designed promote sustained PD.This 12-month single-blind (assessor), pilot, comparative-effectiveness, randomized controlled study.An mHealth-mediated (walking pedometer plus engagement planned supported by...
Testosterone exerts some effects on the cardiovascular system that could be considered beneficial; other may potentially increase risk of (CV) events. Neither long-term efficacy nor safety testosterone treatment has been studied in an adequately-powered randomized trial.The Replacement therapy for Assessment Vascular Events and ResponSE hypogonadal men (TRAVERSE) study is a randomized, double-blind, placebo-controlled, parallel group, non-inferiority, multicenter study. Eligible participants...
Abstract Context Few long-term randomized trials have evaluated the efficacy of testosterone replacement therapy (TRT) in improving sexual function and hypogonadal symptoms men with hypogonadism whether effects are sustained beyond 12 months. Objective The Testosterone Replacement for Assessment Vascular Events ResponSE (TRAVERSE) study effect TRT on major adverse cardiovascular events middle-aged older hypogonadism. Sexual Function Study, nested within parent trial, determined...
Importance Testosterone deficiency causes mild anemia. Whether testosterone replacement therapy (TRT) can correct anemia or prevent the development of in men with hypogonadism remains incompletely understood. Objective To assess efficacy TRT correcting and anemia, reducing risk developing those without Design, Setting, Participants This randomized, placebo-controlled trial included at 316 US sites enrolled between May 2018 February 2022. study was nested within Replacement Therapy for...
Importance The effect of testosterone replacement therapy (TRT) on the risk prostate cancer and other adverse events is unknown. Objective To compare TRT vs placebo incidences high-grade cancers (Gleason score ≥4 + 3), any cancer, acute urinary retention, invasive procedures, pharmacologic treatment for lower tract symptoms in men with hypogonadism. Design, Setting, Participants This placebo-controlled, double-blind randomized clinical trial enrolled 5246 (aged 45-80 years) from 316 US sites...
Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related in NAD has been postulated to contribute diseases.
Abstract Context Whether circulating testosterone, dihydrotestosterone, and estradiol levels or testosterone replacement therapy (TRT) affects the risk of COVID-19 whether response to TRT remains unknown. Objective The study evaluated baseline are associated with developing treatment TRT. Methods Among 5204 men, aged 45 80 years, hypogonadism in TRAVERSE trial, 379 developed COVID-19. We compared on-treatment hormone levels, safety efficacy participants without diagnosis. Results Neither nor...
The purpose of this study was to assess the relationship between lifestyle factors and abdominal subcutaneous adipose tissue (SAT) visceral (VAT) in a community-based setting.Cross-sectional associations (dietary quality, physical activity, smoking, alcohol consumption) SAT VAT volumes were examined 2,926 Framingham Heart Study participants (48.6% women, aged 50 +/- 10 years).Diets consistent with 2005 Dietary Guidelines Adherence Index greater activity inversely associated (P <...