A5086644901- Frailty in Older Adults
- Nutrition and Health in Aging
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Body Composition Measurement Techniques
- 3D Printing in Biomedical Research
- Health Systems, Economic Evaluations, Quality of Life
- Nanoparticle-Based Drug Delivery
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Bone Tissue Engineering Materials
- Global Health Care Issues
- Nanoplatforms for cancer theranostics
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Additive Manufacturing and 3D Printing Technologies
- Systemic Lupus Erythematosus Research
- Parvovirus B19 Infection Studies
- Health and Well-being Studies
- Atherosclerosis and Cardiovascular Diseases
- Geriatric Care and Nursing Homes
- Pesticide Exposure and Toxicity
- Infectious Diseases and Mycology
- Contact Dermatitis and Allergies
- Stoma care and complications
Beijing Normal University
2025
Hong Kong Baptist University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Sun Yat-sen University
2025
Beijing Normal University - Hong Kong Baptist University United International College
2025
Nanjing Medical University
2024
National Cheng Kung University Hospital
2002-2024
Shantou University
2024
Anhui University of Traditional Chinese Medicine
2023-2024
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
16S rRNA sequencing of human fecal samples has been tremendously successful in identifying microbiome changes associated with both aging and disease. A number studies have described microbial alterations corresponding to physical frailty nursing home residence among individuals. gut-muscle axis through which the influences skeletal muscle growth/function hypothesized. However, yet be examined sarcopenia. Here, we collected 60 healthy controls (CON) 27 sarcopenic (Case)/possibly (preCase)...
Background Sarcopenia is closely associated with a poor quality of life and mortality, its prevention treatment represent critical area research. Resistance training an effective for older adults sarcopenia. However, they often face challenges when receiving traditional rehabilitation treatments at hospitals. Objective We aimed to compare the effects digital program those therapist-supervised on Methods In total, 58 sarcopenia were recruited offline randomized (1:1) into 2 groups:...
Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel survivin siRNA to enhance antitumor outcomes Mingji Jin,1 Guangming Jin,2 Lin Kang,1 Liqing Chen,1 Zhonggao Gao,1 Wei Huang11State Key Laboratory of Bioactive Substance Function Natural Medicines, Institute Materia Medica, Chinese Academy Medical Sciences Peking Union College, Beijing, China; 2Department Diagnostic Radiology 2, Yanbian University Hospital, Yanji, Jilin, China...
Abstract Background Fragmentation of services increases health and social care burden as people live longer with higher prevalence diseases, frailty dependency. Local evidence for implementing person-centred integrated is urgently needed to advance practice policies achieve healthy ageing. Objective To test the feasibility impact World Health Organization's (WHO) Integrated Care Older People (ICOPE) approach in China. Design A randomised controlled trial examining ICOPE approach, evaluating...
Nanoparticle-mediated small interfering RNA (siRNA) delivery is a promising therapeutic strategy in various cancers. However, it difficult to deliver degradative siRNA tumor tissue, and thus safe efficient vector for essential cancer therapy. In this study, poly(ethylene glycol)-modified chitosan (PEG-CS) was synthesized successfully delivering nucleic acid drug. We deemed that PEGylated CS could improve its solubility by forming stable loaded nanoparticles, enhancing transfection efficiency...
Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts potential application by systematic administration. Herein, we constructed a novel pH-activated "sheddable" PEG-coated nanoparticle effective primary tumors metastases, which was based on the conjugation catechol group modified...
Objectives: The World Health Organization proposed intrinsic capacity (IC) model to guide the implementation of person-centered care plan aimed at preserving or reserving functional ability, especially in frail older adults. We show trajectory IC and overlap between impairment frailty investigate correlation domains status transitions. Method: Longitudinal observational study covering 230 community-dwelling adults (mean age 84.0 ± 4.5 years) baseline, transition information 2-year follow-up...
Abstract The integration of hierarchical structure, chemistry, and functional activity within tissue‐engineered scaffolds is great importance in mimicking native bone tissue. Bone a highly mineralized tissue which forms at ambient conditions by continuous crystallization the mineral phase an organic matrix presence residing cells. Despite recent advances biofabrication complex engineered tissues, replication heterogeneity microenvironments has been major challenge constructing biomimetic...
An ideal carrier that delivers small interfering RNA (siRNA) should be designed based on two criteria: cellular-mediated internalization and endosomal escape. Poly(histidine-arginine)6(H6R6) peptide was introduced into chitosan (CS) to create a new CS derivative for siRNA delivery, 6-polyarginine (R6) as cell-penetrating peptides facilitated nanoparticle cellular has been proved in our previous research, 6-polyhistidine (H6) mediated the endosome escape resulted rapid releasing tumor...
Frailty is a new prognostic factor in cardiovascular medicine due to the aging and increasingly complex nature of elderly patients. It useful meaningful prospectively analyze manner which frailty predicts short-term outcomes for patients with acute coronary syndrome (ACS).Patients aged ≥ 65 years, diagnosis ACS from cardiology department geriatrics were included single-center. Clinical data including syndromes collected using Comprehensive Geriatrics Assessment. was defined according Scale...