A5025225986- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Aging, Health, and Disability
- Chronic Disease Management Strategies
- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Body Composition Measurement Techniques
- Balance, Gait, and Falls Prevention
- Intensive Care Unit Cognitive Disorders
- Cerebral Palsy and Movement Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Technology Use by Older Adults
- Dialysis and Renal Disease Management
- Global Health Care Issues
- Long-Term Effects of COVID-19
- Nutritional Studies and Diet
- Mental Health and Psychiatry
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical Practices and Patient Outcomes
- Emergency and Acute Care Studies
- Clinical practice guidelines implementation
- Hip and Femur Fractures
- Acute Ischemic Stroke Management
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2024
Hospital Perpetuo Socorro
1999-2024
Complejo Hospitalario Universitario de Albacete
2015-2024
Instituto de Salud Carlos III
2017-2024
University of Castilla-La Mancha
2011-2024
Centro de Investigación Biomédica en Red
2022-2024
Australian Institute for Musculoskeletal Science
2024
Western Health
2024
The University of Melbourne
2024
Hospital General Universitario de Albacete
2012-2024
Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia few drug-induced adverse events, including large elderly cohort (median age, 81 years). An additional 48 cases mild-moderate recovered uneventfully. organotypic 3D cultures of primary human liver cells, demonstrate that interferon-α2 increases ACE2 expression infectivity parenchymal cells by...
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
<h3>Importance</h3> Neurofibrillary tangles composed of aggregated tau protein are one the neuropathological hallmarks Alzheimer disease (AD) and correlate with clinical severity. Monoclonal antibodies targeting may have potential to ameliorate AD progression by slowing or stopping spread and/or accumulation pathological tau. <h3>Objective</h3> To evaluate safety efficacy monoclonal anti-tau antibody semorinemab in prodromal mild AD. <h3>Design, Setting, Participants</h3> This phase 2...
Age, frailty, disability, institutionalization, multimorbidity or comorbidity are main risk factors for serious health adverse outcomes in older adults. However, the adjusted relevance of each them order to determine which characteristics must be importance policies this population group, has not been established.
Background/Objectives To analyze mortality, costs, residents and personnel characteristics, in six long-term care facilities (LTCF) during the outbreak of COVID-19 Spain. Design Epidemiological study. Setting Six open LTCFs Albacete (Spain). Participants 198 190 workers from LTCF A were included, between 2020 March 6 April 5. data also collected for same period time, including 1,084 residents. Measurements Baseline demographic, clinical, functional, cognitive nutritional variables collected....
Abstract Background/Objectives The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID‐19) vaccine in older adults with different frailty disability profiles have not been well determined. Our objective was to analyze mRNA COVID‐19 across profiles. Design Multicenter longitudinal cohort study. Setting participants A total 134 residents aged ≥65 years five long‐term care facilities (LTCFs) Albacete, Spain. Intervention measurements Residents were administered two doses...
This randomized clinical trial examines the effectiveness and generalizability of implementing a multicomponent exercise program for treating functional decline associated with acute hospitalization in very old patients.
Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses geriatric cohorts lacking. Our objective was analyze efficacy older with COVID-19 moderate-to-severe pneumonia.