A5059422297- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Asthma and respiratory diseases
- PARP inhibition in cancer therapy
- Diabetes Treatment and Management
- Respiratory and Cough-Related Research
- Parathyroid Disorders and Treatments
- Migraine and Headache Studies
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Respiratory Support and Mechanisms
- Multiple Sclerosis Research Studies
- interferon and immune responses
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Safe Handling of Antineoplastic Drugs
- Medication Adherence and Compliance
- Colorectal Cancer Treatments and Studies
- RNA and protein synthesis mechanisms
- Medical Device Sterilization and Disinfection
- Animal health and immunology
- Biomarkers in Disease Mechanisms
- Atrial Fibrillation Management and Outcomes
Ospedale Misericordia - Grosseto
2018-2023
Azienda Usl Toscana Centro
2020-2023
Azienda Ospedaliera Universitaria Senese
2023
Misericordia Community Hospital
2022
Mario Negri Institute for Pharmacological Research
2021
Italian Medicines Agency
2016
Università Cattolica del Sacro Cuore
2016
Ospedale di Livorno
2009
University of Pisa
1989
Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia few drug-induced adverse events, including large elderly cohort (median age, 81 years). An additional 48 cases mild-moderate recovered uneventfully. organotypic 3D cultures of primary human liver cells, demonstrate that interferon-α2 increases ACE2 expression infectivity parenchymal cells by...
This real-world analysis evaluated the clinical and economic burden of non-dialysis-dependent CKD patients with without secondary hyperparathyroidism (sHPT) in Italy. An observational retrospective study was conducted using administrative databases containing a pool healthcare entities covering 2.45 million health-assisted individuals. Adult hospitalization discharge diagnoses for stages 3, 4, 5 were included from 1 January 2012 to 31 March 2015 stratified presence/absence sHPT. Of 5710...
The combination of atrial fibrillation (AF) and acute coronary syndrome (ACS) is a complex situation in which three-dimensional risk—cardioembolic, coronary, hemorrhagic—has to be carefully managed. Triple antithrombotic therapy (TAT) burdened with high risk serious bleeding, while dual an anticoagulant (DAT) likely provides only suboptimal protection early after stent implantation. Moreover, TAT precludes the advantages provided by use latest more potent P2Y12 inhibitors ACS patients. Here,...
because of different human behaviours, SARS-CoV-2 spread may be lower in spring/summer. On the contrary, it is not clearly known whether clinical course/severity hospitalized patients infected by can various seasons..to understand there were differences severity COVID-19 who had contracted infection winter versus those spring/summer.observational retrospective cohort study.from administrative database surveillance system and that hospital discharge, a (8,221, 653 which hospitalized) tested...
Purpose: A retrospective analysis of real-world data was performed to assess the epidemiology and economic burden multiple sclerosis (MS), relapsing-remitting MS (RRMS), secondary-progressive (SPMS) in Italy. Patients Methods: An observational study on administrative databases from a sample Italian entities carried-out. Between 01/2010– 12/2017, patients with ≥ 1 diagnosis code (ICD-9-CM:340 and/or exemption code:046) disease-modifying therapies (DMTs) prescription, were included. Among...
Objective This study aimed to describe the demographic and clinical characteristics of migraineurs prescribed ≥1 migraine prophylactic therapy, analyze their therapeutic pathways, healthcare resource consumption, related costs.Methods retrospective analysis was based on administrative databases from two regions three local health units in Italy. Adult patients with discharge diagnosis for or prescription migraine-specific drugs, emergency room visit 1 January 2010 31 December 2016 were...
AIM: The aim of the study was to evaluate healthcare resource use and related costs for management people living with Human Immunodeficiency Virus (PLWHIV) without comorbidities, compare burden comorbidities in PLWHIV general population.METHODS: An observational retrospective analysis, based on administrative laboratory databases from 6 Italian Local Health Units (LHUs) performed. Individuals receiving either an HIV treatment [Antiretroviral therapy (ART) – ATC code: J05A)], or positive test...
This study is aimed at estimating the proportion of type 2 diabetes mellitus (T2DM) patients treated with basal insulin (insulin glargine U100) and evaluating daily dose, treatment pattern, adherence to these patients. Data from administrative laboratory databases 3 Italian Local Health Units were retrospectively collected analyzed. All a diagnosis T2DM between 01/01/2012 31/12/2012 considered, those least prescription 01/01/2013 31/12/2014 included followed up for one year. For each...
Abstract This first of its kind study provides objective context to the potential mechanism action corticosteroid use in COVID-19 patients from 3 separate European medical centers by connecting inflammatory biomarkers IgG levels for SARS-CoV-2 spike protein antigens and neutralization ACE2 binding within infected individuals. CXCL9 is described herein as an important biomarker disease severity with serology response profiles corticosteroid-treated patients.
Introduction: Many uncontrolled severe asthmatics are not on biologic therapy. We hypothesized that using a prescription database could help us identify them. Material and Methods: 3309 patients who received at least one Montelukast in 2019 were extracted from our database. Number of packages/year, types dosages ICS, LABA, ICS/LABA, LAMA monoclonal antibodies considered for each patient. In analysis, subjects took > 7 packages ICS/LABA + LTRA +/– (high adherent) the number oral...