A5001856684- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Long-Term Effects of COVID-19
- Hepatocellular Carcinoma Treatment and Prognosis
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Intraperitoneal and Appendiceal Malignancies
- Advanced Breast Cancer Therapies
- Economic and Financial Impacts of Cancer
- Iron Metabolism and Disorders
- Frailty in Older Adults
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- Kawasaki Disease and Coronary Complications
- Bariatric Surgery and Outcomes
- Brain Metastases and Treatment
- Vasculitis and related conditions
Azienda Ospedaliera Universitaria Pisana
2010-2023
Carlo Forlanini Hospital
2004-2022
University of Pisa
1993-2020
Azienda Ospedaliera San Camillo-Forlanini
2005-2015
Ospedale Cisanello
2009-2010
IRCCS San Camillo Hospital
2009
University of Modena and Reggio Emilia
2009
University of Bari Aldo Moro
2009
Bristol-Myers Squibb (United States)
2007
University of Michigan–Ann Arbor
2007
Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia few drug-induced adverse events, including large elderly cohort (median age, 81 years). An additional 48 cases mild-moderate recovered uneventfully. organotypic 3D cultures of primary human liver cells, demonstrate that interferon-α2 increases ACE2 expression infectivity parenchymal cells by...
This study was conducted to evaluate the impact of low-molecular-weight heparin (LMWH) on outcome patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. is a prospective observational including consecutive laboratory-confirmed SARS-CoV-2 pneumonia admitted University Hospital Pisa (March 4-April 30, 2020). Demographic, clinical, and data were collected. The primary endpoint 30-day mortality. secondary composite death or distress (ARDS). Low-molecular-weight...
Abstract Accurate risk stratification in COVID-19 patients consists a major clinical need to guide therapeutic strategies. We sought evaluate the prognostic role of estimated pulse wave velocity (ePWV), marker arterial stiffness which reflects overall integrity and aging, hospitalized with COVID-19. This retrospective, longitudinal cohort study, analyzed total population 1671 subjects consisting 737 consecutively recruited from two tertiary centers (Newcastle cohort: n = 471 Pisa 266)...
<i>Objective:</i> An increasing number of patients with advanced pancreatic or biliary tract cancer who progress after a gemcitabine-containing regimen are candidates for further chemotherapy. We therefore evaluated fully oral capecitabine and celecoxib (CapCel) as second-line treatment in these patients. <i>Methods:</i> Thirty-five documented progressive disease first-line were enrolled. Capecitabine was administered at dose 1,000 mg/m<sup>2</sup> b.i.d....
High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). then explored relevance these pathways defining mortality complications risk potential effects treatments attenuate such risk. In this single-center, prospective, observational study we...
Neoadjuvant chemotherapy has been reported to be extremely active in head and neck cancer but failed give a statistically significant improvement survival.From 1981 1994, 33 operable patients with locally advanced oral cavity received cisplatin-based before surgery. Postoperative radiotherapy was performed high-risk patients.The overall clinical pathologic complete response rates neoadjuvant were 48% 30%, respectively. At median follow-up of 7.0 years (range, 0.3-15.3+ years), the 5-year...
The aim of this study was to evaluate serum levels interleukin-1β (IL-1β), chemokine (C-X-C motif) ligand 10 (CXCL10), and interferon-gamma (IFN-γ) in a series patients with "mixed cryoglobulinemia hepatitis C virus chronic infection" (MC + HCV) the presence or absence autoimmune thyroiditis (AT) relate them clinical phenotype these patients. Serum IL-1β, IFN-γ, CXCL10 were assayed 30 MC HCV without AT, sex- age-matched controls. Cryoglobulinemic showed significantly higher mean IL-1β than...
The authors describe a case of Takayasu's arteritis in twenty-five-year-old Italian woman, characterized by nonspecific symptoms (weakness, arthralgias, fever) and elevated erythrocyte sedimentation rate early onset these at the age about twenty-three years diagnosis, only eighteen months after symptomatology absence progression disease under corticosteroid therapy with follow-up three uneventful pregnancy ending cesarean section birth baby without maternal neonatal complications.
The response rate to salvage chemotherapy in advanced ovarian cancer has been disappointing patients who do not respond or relapse after platinum-containing regimens. In these cases, the identification of new drugs is a substantial challenge. efficacy one these, paclitaxel, already assessed many phase II trials. From July 1993 October 1995, 33 with cancer, recurrent refractory platinum-based regimens, entered our study. Paclitaxel was given by 3-hour intravenous infusion every 3 weeks. All...
15543 Background: Vinflunine (VFL) is a new microtubule inhibitor of the vinca alkaloid class with clinical activity in TCCU (S. Culine, BJC 2006). This trial was conducted to define VFL platinum-refractory patients (pts). Methods: Multicenter, single-arm study. Primary endpoint: Objective response rate (Independent Review; WHO criteria). Planned sample size: 150 pts. Main pt eligibility: at least one measurable lesion; documented progression within 12 months last dose platinum-containing...
4128 Background: Several studies suggest that increased gene copy number of the Epidermal Growth Factor Receptor (EGFR) or presence mutations K-ras oncogene are associated with cetuximab response resistance in patients (pts) mCRC. In this setting data not yet available regarding deleted colorectal cancer (DCC), a tumor-suppressor located at chromosome 18q21, although DCC could theoretically modulate EGFR/K-RAS pathway. This study aimed to identify biological predictors for sensitivity and...
Regorafenib (REG) and trifluridine/tipiracil (FTD/TPI) have been shown to improve overall survival in patients with refractory metastatic colorectal cancer. The aim of our study was evaluate the efficacy safety profiles these agents administered sequence real world practice.Clinical data treated beyond 2°line REG or FTD/TPI between January 2016 August 2020, were retrospectively collected from eight institutes Lazio Region.We included 49 both drug sequences. A total 28 G3/G4 toxicity events...
To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor alpha (TNF-alpha) in a large series patients with hepatitis C associated mixed cryoglobulinemia (MC+HCV).Serum NTproBNP TNF-alpha were assayed 50 MC+HCV, sex- age-matched controls.Cryoglobulinemic showed significantly higher mean than controls (P < 0.001; Mann-Whitney U test). By defining high level as value 125 pg/mL (the single cut-off point for outpatients under 75 years age), 30%...