A5064535615- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Estrogen and related hormone effects
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Hepatitis Viruses Studies and Epidemiology
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Pregnancy and Medication Impact
- Alcohol Consumption and Health Effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microscopic Colitis
University of Modena and Reggio Emilia
2015-2024
Azienda Ospedaliero-Universitaria di Modena
2015-2024
Grant Medical Center
2024
OhioHealth
2024
Gastroenterology Hospital "Saverio de Bellis"
2023-2024
University of Southern California
2023
Policlinico S.Orsola-Malpighi
2023
Italian Medicines Agency
2023
Italian Association for Cancer Research
1997-2023
Associazione Italiana Sclerosi Multipla
2023
Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) used to justify preprocedure use fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides more comprehensive global assessment than tests (international normalized ratio [INR] platelet count), its may avoid unnecessary blood product transfusion (defined this study as INR >1.8 count <50 × 10(9) /L) who will be...
Abstract A multicenter randomized controlled trial established sorafenib as a standard of care for patients with advanced hepatocellular carcinoma (HCC). Because the study was prematurely interrupted due to survival benefits in arm, we conducted an observational adequately assess risks and this regimen field practice. Starting 2008, all clinically compensated HCC those intermediate who were unfit or failed respond ablative therapies consecutively evaluated six liver centers Italy,...
The biological heterogeneity of hepatocellular carcinoma (HCC) makes prognosis difficult. We translate the results a genome-wide high-throughput analysis into tool that accurately predicts at presentation tumour growth and survival patients with HCC.Ultrasound surveillance identified HCC in 78 (training set) 54 (validation consecutive cirrhosis. Patients underwent two CT scans 6 weeks apart (no treatment in-between) to determine volumes (V0 V1) calculate doubling time. Baseline-paired...
Progressive familial intrahepatic cholestasis (PFIC) and benign recurrent (BRIC) are clinically distinct hereditary disorders. PFIC patients suffer from chronic develop liver fibrosis. BRIC experience intermittent attacks of that resolve spontaneously. Mutations in ATP8B1 (previously FIC1 ) may result or BRIC. We report the genomic organization mutation analyses 180 families with identified 54 disease mutations, including 10 mutations predicted to disrupt splicing, 6 nonsense 11 small...
Clinical course in hepatocellular carcinoma may be very different. We prospectively evaluated 96 patients with unsuitable for radical therapy to investigate factors that could influence survival. Clinical, pathologic, and molecular data of were analyzed by univariate multivariate analysis. The overall actuarial probability survival at year 1, 2, 3, 4, 5, 6 was 72%, 41%, 38%, 24%, 20%, 9%. At analysis, alpha-fetoprotein (AFP) ( P = .0082); alkaline phosphatase .0281); bilirubin .0076);...
Recent reports suggested that direct acting antivirals (DAAs) might favor hepatocellular carcinoma (HCC). In study 1, we studied the proangiogenic liver microenvironment in 242 DAA-treated chronic hepatitis C patients with advanced fibrosis. Angiopoietin-2 (ANGPT2) expression was tissue (cirrhotic and/or neoplastic) from recurrent, de novo, nonrecurrent HCC, or never developing HCC. Circulating ANGPT2,vascular endothelial growth factor (VEGF), and C-reactive protein (CRP) were also measured....
Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure.
Guidelines recommend variceal screening in patients with cirrhosis to identify varices at high risk of bleeding requiring primary prophylaxis. Non-invasive criteria rule out high-risk will avoid unnecessary endoscopies. Recent Baveno VI define compensated whom endoscopy can be avoided as those a liver stiffness by transient elastography <20 kPa and platelet count >150 000/mm3. AIMS: To validate two cohorts different prevalence determine whether alternate parameters not including would...
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury it second most common cause failure. Mitochondrial dysfunction contributes APAP-induced but mechanism by which APAP causes hepatocyte toxicity not completely understood. Therefore, we lack efficient therapeutic strategies this pathology. Here show that interferes with formation mitochondrial respiratory supercomplexes via negative regulator MCJ, leads...
Background & AimsNumerous studies have evaluated the role of human albumin (HA) in managing various liver cirrhosis-related complications. However, their conclusions remain partially controversial, probably because HA was different settings, including indications, patient characteristics, and dosage duration therapy.MethodsThirty-three investigators from 19 countries with expertise complications were invited to organize an International Special Interest Group. A three-round Delphi consensus...