Juan Manuel Falcón‐Pérez
A5054735287- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- Viral Infections and Vectors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Cancer, Lipids, and Metabolism
- Advanced Proteomics Techniques and Applications
- Metabolism and Genetic Disorders
- Cellular transport and secretion
- Diet, Metabolism, and Disease
- Trace Elements in Health
- Nanoplatforms for cancer theranostics
- Neonatal Health and Biochemistry
- Prostate Cancer Treatment and Research
- Porphyrin Metabolism and Disorders
- Gut microbiota and health
- Mass Spectrometry Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016-2025
CIC bioGUNE
2016-2025
Ikerbasque
2016-2025
Instituto de Salud Carlos III
2015-2025
Centro de Investigación Biomédica en Red
2012-2025
Centre for Biomedical Network Research on Rare Diseases
2023
Exosome Diagnostics (United States)
2018-2021
Hospital de Basurto
2021
Basque Government
2020
Medical Research Network
2018-2020
ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions extracellular vesicles (EVs), collective term covering various subtypes cell‐released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, many other names. However, specific issues arise when working with these entities, whose size amount often make them difficult to obtain as relatively...
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity transfer proteins, lipids nucleic acids, thereby influencing various physiological pathological functions recipient parent cells. While intensive investigation has targeted role EVs different processes, for example, cancer autoimmune diseases, EV-mediated maintenance homeostasis regulation remained less...
Extracellular vesicles (EVs) are membraneous released by a variety of cells into their microenvironment. Recent studies have elucidated the role EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, as possible reservoirs biomarkers. These findings generated immense interest, along with an exponential increase molecular data pertaining to EVs. Here, we describe Vesiclepedia, manually curated compendium (lipid, RNA, protein) identified different classes...
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types participate in physiological pathophysiological processes. EVs mediate intercellular communication cell‐derived extracellular signalling organelles that transmit specific information from their of origin to target cells. As a result these properties, defined may serve novel tools for various therapeutic approaches, including (a) anti‐tumour therapy, (b) pathogen vaccination, (c)...
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of cell origin and change functions phenotypes other cells. These features indicate strong biomarker therapeutic potential have generated broad interest, as evidenced by steady year-on-year increase in numbers scientific publications about EVs. Important advances been made EV metrology understanding applying biology. However, hurdles remain to realising EVs domains ranging from basic biology clinical...
Exosomes represent a discrete population of vesicles that are secreted from various cell types to the extracellular media. Their protein and lipid composition consequence sorting events at level multivesicular body, central organelle which integrates endocytic secretory pathways. Characterization exosomes different biological samples has shown presence common as well cell-type specific proteins. Remarkably, content is modified upon pathological or stress conditions. Hepatocytes play role in...
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of vesicular nomenclatures and components, online searches for EV-related publications components currently challenging. Results: We present an improved version EVpedia, a public database EVs research. This community web portal contains identification orthologous bioinformatic tools personalized function. EVpedia includes 6879 publications, 172...
ABSTRACT Bioinformatics tools are imperative for the in depth analysis of heterogeneous high‐throughput data. Most software developed by specific laboratories or groups companies wherein they designed to perform required group. However, such may fail capture “what community needs a tool”. Here, we describe novel community‐driven approach build comprehensive functional enrichment tool. Using existing FunRich tool as template, invited researchers request additional features and/or changes....
Next-generation sequencing allows now the of small RNA molecules and estimation their expression levels. Consequently, there will be a high demand bioinformatics tools to cope with several gigabytes sequence data generated in each single deep-sequencing experiment. Given this scene, we developed miRanalyzer, web server tool for analysis experiments RNAs. The requires simple input file containing list unique reads its copy numbers (expression levels). Using these data, miRanalyzer (i) detects...
Research on extracellular vesicles (EVs) is growing exponentially due to an increasing appreciation of EVs as disease biomarkers and therapeutics, expanding number EV-containing materials under study, application new preparation, detection, cargo analysis methods. Diversity both sources methodologies imposes challenges the comparison measurement results between studies laboratories. While reference guidelines minimal requirements for EV research have achieved important objective assembling...
Abstract Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last decade urinary (uEVs) were shown to mirror molecular processes as well physiological pathological conditions kidney, urothelial prostate tissue. Therefore, several methods isolate characterize uEVs have been developed. However, methodological aspects EV separation analysis, including normalization...
Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis. Several conditions, such as primary sclerosing cholangitis (PSC), are risk factors. Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma (HCC) is sometimes difficult. Accurate noninvasive biomarkers for PSC, CCA, HCC not available. In the search novel biomarkers, serum extracellular vesicles (EV) were isolated from (n = 43), PSC 30), or 29) patients healthy...
ABSTRACT Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central the biogenesis, content, function of EVs are their delimiting lipid bilayer membranes. To evaluate research progress on membranes EVs, International Society for Extracellular Vesicles (ISEV) conducted a workshop in March 2018 Baltimore, Maryland, USA, bringing together key opinion leaders hands‐on researchers who were selected basis submitted...
BackgroundFibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with brain through enteric nervous system (ENS); its disruption has been associated psychiatric and gastrointestinal disorders. To gain an insight into pathogenesis of fibromyalgia identify diagnostic biomarkers, we combined different omics techniques to analyse serum composition.MethodsWe collected faeces blood samples...
Extracellular vesicles (EVs) are considered sophisticated vehicles for cell-to-cell communication, thanks to the possibility of handling a variable cargo in shell with multiple types decoders. Surface glycosylation EVs is method that could be used control their interaction different cells and, consequently, biodistribution body. Herein, we produced derived from mouse liver proliferative cells, and treated them neuraminidase, an enzyme digests terminal sialic acid residues glycoproteins....