A5076672133- Telomeres, Telomerase, and Senescence
- Differential Equations and Boundary Problems
- MicroRNA in disease regulation
- advanced mathematical theories
- Nonlinear Waves and Solitons
- Extracellular vesicles in disease
- Algebraic and Geometric Analysis
- Differential Equations and Numerical Methods
- Advanced Differential Equations and Dynamical Systems
- Numerical methods for differential equations
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Advanced Mathematical Modeling in Engineering
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Meromorphic and Entire Functions
- Circular RNAs in diseases
- Polynomial and algebraic computation
- Cancer-related Molecular Pathways
- Mathematical functions and polynomials
- Mathematical Dynamics and Fractals
- Quantum chaos and dynamical systems
- Virus-based gene therapy research
Sophia University
2014-2024
Hiroshima University
2015-2024
Higashihiroshima Medical Center
2020
Bio-Medical Science (South Korea)
2017
Shibaura Institute of Technology
2015
Jagiellonian University
2014
University Medical Center
2014
Pohang University of Science and Technology
2014
AGH University of Krakow
2014
Wakayama University
2010
Secreted membrane‐enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology medicine. Importantly, it is currently technically challenging to obtain totally pure fraction free from non‐vesicular components for functional studies, therefore there need establish guidelines analyses of these reporting studies on biology....
p16CDKN2 specifically binds to and inhibits the cyclin-dependent kinases CDK4 CDK6, which function as regulators of cell cycle progression in G1 by contributing phosphorylation retinoblastoma protein (pRB). Human lines lacking functional pRB contain high levels p16 RNA protein, suggesting a negative feedback loop might regulate expression late G1. By combination nuclear run-on assays promoter analyses human fibroblasts expressing temperature-sensitive simian virus 40 T antigen, we show that...
The release of RNA-containing extracellular vesicles (EV) into the milieu has been demonstrated in a multitude different vitro cell systems and variety body fluids. EV are limelight for their capacity to communicate genetically encoded messages other cells, suitability as candidate biomarkers diseases, use therapeutic agents. Although EV-RNA attracted enormous interest from basic researchers, clinicians, industry, we currently have limited knowledge on which mechanisms drive regulate RNA...
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of vesicular nomenclatures and components, online searches for EV-related publications components currently challenging. Results: We present an improved version EVpedia, a public database EVs research. This community web portal contains identification orthologous bioinformatic tools personalized function. EVpedia includes 6879 publications, 172...
Cellular senescence acts as a barrier to cancer progression, and microRNAs (miRNAs) are thought be potential regulators. However, whether senescence-associated miRNAs (SA-miRNAs) contribute tumor suppression remains unknown. Here, we report that miR-22, novel SA-miRNA, has an impact on tumorigenesis. miR-22 is up-regulated in human senescent fibroblasts epithelial cells but down-regulated various cell lines. overexpression induces growth acquisition of phenotype normal cells. knockdown...
Elevated amyloid‐β peptide (Aβ) in brain contributes to Alzheimer's disease (AD) pathogenesis. We demonstrated the presence of exosome‐associated Aβ cerebrospinal fluid (CSF) cynomolgus monkeys and APP transgenic mice. The levels notably decreased CSF aging animals. also determined that neuronal exosomes, but not glial had abundant glycosphingolipids could capture Aβ. Infusion exosomes into brains mice amyloid depositions, similarly what reported previously on neuroblastoma‐derived exosomes....
Abstract A substantial proportion of patients with acute graft-versus-host disease (aGVHD) respond to cell therapy culture-expanded human bone marrow mesenchymal stromal/stem cells (BM-MSCs). However, the mechanisms by which these can ameliorate aGVHD-associated complications remain be clarified. We show here that BM-MSC-derived extracellular vesicles (EVs) recapitulated therapeutic effects BM-MSCs against aGVHD. Systemic infusion EVs prolonged survival mice aGVHD and reduced pathologic...
Telomerase is an enzyme that can reconstitute the ends (telomeres) of chromosomes after cell division and thus circumvent cumulative damage occurs in normal adult somatic cells during successive mitotic cycles. Recently, it has been proposed this should, therefore, be detectable immortal malignant but not their counterparts, which stop dividing senesce. Accordingly, telomerase activity reported many types tumors, including those gastrointestinal tract, breast, lung little information was...
In addition to the Watson−Crick double helix, secondary DNA structures are thought play important roles in a variety of biological processes. One example is G-quadruplex structure that formed at chromosome ends, which inhibits telomerase activity by blocking its access telomeres. represent new class molecular targets for DNA-interactive compounds may be useful target Here, we reported first enantioselective recognition quadruplex chiral cyclic helicene. We propose ligand-binding cleft...
Abstract Cancer‐prone syndrome of premature chromatid separation (PCS syndrome) with mosaic variegated aneuploidy (MVA) is a rare autosomal recessive disorder characterized by growth retardation, microcephaly, childhood cancer, all chromosomes, and mosaicism for various trisomies monosomies. Biallelic BUB1B mutations were recently reported in five eight families MVA (probably identical to the PCS syndrome). We here describe molecular analysis (encoding BubR1) seven Japanese syndrome....
The ATM- and Rad3-related (ATR) kinase is a master regulator of the DNA damage response, yet how ATR activated toward different substrates still poorly understood. Here, we show that phosphorylates Chk1 RPA32 through distinct mechanisms at replication-associated double-stranded breaks (DSBs). In contrast to rapid phosphorylation Chk1, progressively phosphorylated by Ser33 during DSB resection prior Ser4/Ser8 DNA-PKcs. Surprisingly, despite its reliance on TopBP1, substantial occurs in...
Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases involved in the degradation and remodeling of matrix physiological pathological processes. MMPs also have a role cell proliferation, migration, differentiation, angiogenesis, apoptosis. We previously identified cancer invasion-related factors by comparing gene expression profiles between parent highly invasive clone cells. metalloproteinase-13 (MMP-13) was as common up-regulated factors. Although MMP-13 slightly...