A5019296552- Extracellular vesicles in disease
- Prion Diseases and Protein Misfolding
- MicroRNA in disease regulation
- Neurological diseases and metabolism
- Trace Elements in Health
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Circular RNAs in diseases
- HIV Research and Treatment
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- HIV/AIDS drug development and treatment
- Cell Adhesion Molecules Research
- Amyotrophic Lateral Sclerosis Research
- RNA Interference and Gene Delivery
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV-related health complications and treatments
- Insect and Arachnid Ecology and Behavior
- HIV/AIDS Research and Interventions
- Insect and Pesticide Research
- interferon and immune responses
- Cellular transport and secretion
- Genetic Neurodegenerative Diseases
Victoria University
2005-2025
Purdue University West Lafayette
2025
La Trobe University
2015-2024
Trans Tasman Radiation Oncology Group
2019-2024
University of Liverpool
2012-2023
German Cancer Research Center
2022
Johns Hopkins University
2022
Heidelberg University
2022
Victoria School of Management
2022
The University of Melbourne
2012-2021
Nivolumab plus ipilimumab or nivolumab alone resulted in longer progression-free and overall survival than a trial involving patients with advanced melanoma. We now report 5-year outcomes the trial.
Secreted membrane‐enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets, encompass a very rapidly growing scientific field in biology medicine. Importantly, it is currently technically challenging to obtain totally pure fraction free from non‐vesicular components for functional studies, therefore there need establish guidelines analyses of these reporting studies on biology....
Extracellular vesicles (EVs) are membraneous released by a variety of cells into their microenvironment. Recent studies have elucidated the role EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, as possible reservoirs biomarkers. These findings generated immense interest, along with an exponential increase molecular data pertaining to EVs. Here, we describe Vesiclepedia, manually curated compendium (lipid, RNA, protein) identified different classes...
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types participate in physiological pathophysiological processes. EVs mediate intercellular communication cell‐derived extracellular signalling organelles that transmit specific information from their of origin to target cells. As a result these properties, defined may serve novel tools for various therapeutic approaches, including (a) anti‐tumour therapy, (b) pathogen vaccination, (c)...
As high-throughput techniques including proteomics become more accessible to individual laboratories, there is an urgent need for a user-friendly bioinformatics analysis system. Here, we describe FunRich, open access, standalone functional enrichment and network tool. FunRich designed be used by biologists with minimal or no support from computational database experts. Using users can perform on background databases that are integrated heterogeneous genomic proteomic resources (>1.5 million...
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of cell origin and change functions phenotypes other cells. These features indicate strong biomarker therapeutic potential have generated broad interest, as evidenced by steady year-on-year increase in numbers scientific publications about EVs. Important advances been made EV metrology understanding applying biology. However, hurdles remain to realising EVs domains ranging from basic biology clinical...
Extracellular vesicles (EVs) represent an important mode of intercellular communication. Research in this field has grown rapidly the last few years, and there is a plethora techniques for isolation characterization EVs, many which are poorly standardized. EVs heterogeneous size, origin molecular constituents, with considerable overlap size phenotype between different populations EVs. Little known about current practices isolation, purification We report here first large, detailed survey...
Introduction microRNA (miRNA) are small non‐coding RNA species that transcriptionally processed in the host cell and released extracellularly into bloodstream. Normally involved post‐transcriptional gene silencing, deregulation of miRNA has been shown to influence pathogenesis a number diseases. Background Next‐generation deep sequencing (NGS) provided ability profile biological fluids making this approach viable screening tool detect biomarkers. However, collection handling procedures blood...
The release of RNA-containing extracellular vesicles (EV) into the milieu has been demonstrated in a multitude different vitro cell systems and variety body fluids. EV are limelight for their capacity to communicate genetically encoded messages other cells, suitability as candidate biomarkers diseases, use therapeutic agents. Although EV-RNA attracted enormous interest from basic researchers, clinicians, industry, we currently have limited knowledge on which mechanisms drive regulate RNA...
Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting rapidly towards clinical applications. However, discrepancies and controversies about the biology, functions, potency of MSC-sEVs have arisen due to several factors: diversity MSCs their preparation; various methods sEV production separation; a lack standardized quality assurance assays; limited reproducibility in vitro vivo functional assays. To address these issues, members four societies...
Prion diseases are transmissible neurodegenerative disorders affecting both humans and animals. The cellular prion protein, PrP C , the abnormal infectious form, Sc found associated with exosomes, which small 50–130 nm vesicles released from cells. Exosomes also contain microRNAs (miRNAs), a class of non-coding RNA, have been utilized to identify miRNA signatures for diagnosis disease. While some miRNAs deregulated in prion-infected brain tissue, role circulating exosomes during disease is...
Abstract Prion diseases are fatal, transmissible neurodegenerative disorders associated with conversion of the host‐encoded prion protein (PrP C ) into an abnormal pathogenic isoform Sc ). Following exposure to infectious agent in acquired disease, infection is propagated lymphoid tissues prior neuroinvasion and spread within central nervous system. The mechanism dissemination perplexing due lack plausible PrP ‐containing mobile cells that could account for between infected uninfected...
Significance Amyotrophic lateral sclerosis (ALS), an incurable motor neuron disease, is associated with mutation and misfolding of the Cu/Zn superoxide dismutase (SOD1) protein. Prior studies found that mutant misfolded SOD1 can convert wild-type (WT) to a form inside living cells in prion-like fashion. We now report WT be transmitted from cell cell, propagated protein perpetuated. Misfolded transmission between mediated through release uptake aggregates or via small membrane-bounded...
Exosomes are small membranous vesicles secreted by a number of cell types including neurons and can be isolated from conditioned media or bodily fluids such as urine plasma. Exosome biogenesis involves the inward budding endosomes to form multivesicular bodies (MVB). When fused with plasma membrane, MVB releases into extracellular environment exosomes. Proposed functions these include roles in cell-cell signaling, removal unwanted proteins, transfer pathogens between cells. One pathogen...