A5066297753- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Research on Leishmaniasis Studies
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Saffron Plant Research Studies
- Viral Infections and Vectors
- Galectins and Cancer Biology
- Trypanosoma species research and implications
- Reproductive Biology and Fertility
- CRISPR and Genetic Engineering
- Advanced Proteomics Techniques and Applications
- Ovarian function and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme function and inhibition
- Health and Wellbeing Research
- Parasitic infections in humans and animals
- Advanced Electron Microscopy Techniques and Applications
Royan Institute
2016-2025
Academic Center for Education, Culture and Research
2016-2025
University of Zanjan
2021-2023
University of Science and Culture
2014-2022
Tabriz University of Medical Sciences
2021-2022
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of cell origin and change functions phenotypes other cells. These features indicate strong biomarker therapeutic potential have generated broad interest, as evidenced by steady year-on-year increase in numbers scientific publications about EVs. Important advances been made EV metrology understanding applying biology. However, hurdles remain to realising EVs domains ranging from basic biology clinical...
Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have been widely reported as promising cell-free products that show therapeutic effects of the parental but not their limitations. Due to intrinsic liver tropism MSC-EVs, they used therapeutics or drug carriers for treatment diseases. However, rapid clearance target site may attenuate efficiency systemically administered MSC-EVs. Herein, sustained release into peritoneum has proposed a new strategy prolong bioavailability...
The main causes of death in patients with severe Coronavirus disease-2019 (COVID-19) are acute respiratory distress syndrome (ARDS) and multiorgan failure caused by a inflammatory cascade. Novel treatment strategies, such as stem-cell-based therapy their derivatives can be used to relieve inflammation these cases. In this study, we aimed evaluate the safety efficacy using mesenchymal stromal cells (MSCs) derived extracellular vesicles COVID-19 patients.
ABSTRACT The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced the past decade. In November 2018, International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs Clinical Theranostic”. Here, we report conclusions roundtable discussions current advancement analysis technologies and provide some guidelines to researchers field consider use EVs application. main challenges requirements EV separation characterization strategies, quality...
Abstract Cell culture‐conditioned medium (CCM) is a valuable source of extracellular vesicles (EVs) for basic scientific, therapeutic and diagnostic applications. culturing parameters affect the biochemical composition, release possibly function CCM‐derived EVs (CCM‐EV). The CCM‐EV task force Rigor Standardization Subcommittee International Society Extracellular Vesicles aims to identify relevant cell parameters, describe their effects based on current knowledge, recommend reporting...
Abstract Extracellular vesicles (EVs) are nanosized with a lipid bilayer that secreted by cells and play critical role in cell‐to‐cell communication. Despite the promising reports regarding their diagnostic therapeutic potential, utilization of EVs clinical setting is limited due to insufficient information about cargo lack standardization isolation analysis methods. Considering protein cargos as key contributors potency, we conducted tandem mass tag (TMT) quantitative proteomics three...
Abstract Background Retinal and/or optic nerve injury is one of the leading causes blindness due to retinal ganglion cell (RGC) degeneration. There have been extensive efforts suppress this neurodegeneration. Various somatic tissue-derived mesenchymal stem cells (MSCs) demonstrated significant neuroprotective and axogenic effects on RGCs. An alternative source MSCs could be human embryonic (ES-MSCs), which proliferate faster, express lower levels inflammatory cytokines, are capable immune...
Abstract Background Asherman syndrome (AS), or intrauterine adhesions, is a main cause of infertility in reproductive age women after endometrial injury. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) are promising candidates for therapies that repair damaged endometria. However, concerns about efficacy attributed to heterogeneity the cell populations EVs. A homogenous population MSCs effective EV subpopulation needed develop potentially therapeutic options regenerative...
Extracellular vesicles (EVs) are nano to-micrometer-sized sacs that released by almost all animal and plant cells act as intercellular communicators transferring their cargos between the source target cells. As a safe scalable alternative to conditioned medium-derived EVs, milk-derived EVs (miEVs) have recently gained great deal of popularity. Numerous studies shown miEVs intrinsic therapeutic actions can treat diseases enhance human health. Additionally, they be used natural drug carriers...
Abstract Background Inflammatory bowel disease (IBD) is a complex gastrointestinal with 2 main subtypes of Crohn’s (CD) and ulcerative colitis (UC), whose diagnosis mainly depends on the medical history, clinical symptoms, endoscopic, histologic, radiological, serological findings. Extracellular vesicles (EVs) are now considered an additional mechanism for intercellular communication, allowing cells to exchange biomolecules. Long noncoding RNAs (lncRNAs) that enriched in EVs have been...
The potential application of extracellular vesicles (EVs) in regenerative and personalized medicine has attracted substantial interest recent years, highlighting the need for standardized protocols their administration preclinical clinical settings. EVs, which play critical roles intercellular communication have significant therapeutic potential, prompted extensive research advancements applications. However, rapid evolution this field also revealed variability how EVs are isolated,...
Stroke imposes a long‐term neurological disability with limited effective treatments available for neuronal recovery. Transplantation of neural stem cells (NSCs) is reported to improve functional outcomes in the animal models brain ischemia. However, use cell therapy accompanied by adverse effects, so research growing cell‐free extracts such as extracellular vesicles (EVs) targeting diseases. In current study, male Wistar albino rats (20 months old) were subjected middle cerebral artery...
Abstract Extracellular vesicles (EVs) have therapeutic effects on osteoarthritis (OA). Some recent strategies could elevate EV's properties including cell aggregation, co-culture, and 3D culture. It seems that a combination of these augment EV production potential. The current study aims to evaluate the quantity yield effect EVs harvested from rabbit mesenchymal stem cells (MSCs) aggregates, chondrocyte their co-aggregates in dynamic culture rat model. MSC chondrocytes were aggregated...
Abstract Nitric oxide (NO) is recognized as an endogenous signaling molecule that plays important role in the defence responses of medicinal plants to NaCl stress. In this study, we investigated effects sodium nitroprusside (SNP) NO donor at three concentrations (0, 100, and 200 µmol l −1 ) alleviate deleterious salt stress (100 mM NaCl) on leaf gas exchange biochemical characteristics Silybum marianum L. seedlings. This study showed significantly decreased relative water content (RWC),...
Age-related macular degeneration (AMD) is a leading cause for visual impairment in aging populations with limited established therapeutic interventions available. Oxidative stress plays an essential role the pathogenesis of AMD, damaging retinal pigment epithelium (RPE), which function and maintenance light-sensing photoreceptors. This study aimed to evaluate effects crocetin, one main components Saffron, on vitro RPE model tert-butyl hydroperoxide (TBHP) induced oxidative using ARPE19...