A5029197076- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Cerebral Palsy and Movement Disorders
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Corneal Surgery and Treatments
- Pancreatic function and diabetes
- Immune cells in cancer
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Spinal Dysraphism and Malformations
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Xenotransplantation and immune response
- Reproductive Biology and Fertility
- Zebrafish Biomedical Research Applications
- Fire Detection and Safety Systems
- Burn Injury Management and Outcomes
- Biomedical Ethics and Regulation
- Botulinum Toxin and Related Neurological Disorders
Academic Center for Education, Culture and Research
2017-2025
Royan Institute
2016-2025
Stem Cell Technology Research Center
2014-2023
Stem Cell Technology (Taiwan)
2021
Cell Technology (China)
2019
Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are few reports allogeneic human mesenchymal stem cells (MSCs) as potential treatment for ARDS. In this phase 1 clinical trial, we present the safety, feasibility, and tolerability multiple infusions high dose MSCs, which originated from placenta umbilical cord, in critically ill COVID-19-induced ARDS patients.A total 11 patients diagnosed with who were admitted to intensive care...
The main causes of death in patients with severe Coronavirus disease-2019 (COVID-19) are acute respiratory distress syndrome (ARDS) and multiorgan failure caused by a inflammatory cascade. Novel treatment strategies, such as stem-cell-based therapy their derivatives can be used to relieve inflammation these cases. In this study, we aimed evaluate the safety efficacy using mesenchymal stromal cells (MSCs) derived extracellular vesicles COVID-19 patients.
This study assessed the safety and efficacy of intrathecal injection umbilical cord tissue mesenchymal stem cells (UCT-MSC) in individuals with cerebral palsy (CP). The diffusion tensor imaging (DTI) was performed to evaluate alterations white-matter integrity.Participants (4-14 years old) spastic CP were assigned 1:1 ratio receive either UCT-MSC or sham procedure. Single-dose (2 × 107) administered experimental group. Small needle pricks lower back sham-control arm. All sedated prevent...
Cell-based therapy has shown promising outcomes in the treatment of cerebral palsy (CP). However, there is no consensus on a standard therapeutic protocol regarding source cells, optimal cell dose, timing and frequency injections, route administration, or use combination therapy. This lack necessitates comprehensive investigation to clarify these crucial yet undefined factors cell-based for CP patients. In this commentary, we discuss compare trends Gross Motor Function Measure-66 following...
Macrophages are multifunctional immune cells widely used in immunological research. While autologous macrophages have been several biomedical applications, allogeneic also demonstrated similar or even superior therapeutic potential. The umbilical cord blood (UCB) is a well-described source of abundant allogenic monocytes and that easy to collect can be processed without invasive methods. Current monocyte isolation procedures frequently result heterogenous cell products, with limited yields,...
Abstract The potential of extracellular vesicles (EVs) isolated from mesenchymal stromal cells in guiding macrophages toward anti‐inflammatory immunophenotypes, has been reported several studies. In our study, we provided experimental evidence a distinctive effect played by Wharton Jelly cell‐derived EVs (WJ‐EVs) on human macrophages. We particularly analyzed their effects evaluating interactions with stellate cells, and protective role liver fibrosis. A three‐step gradient method was used...
Abstract The MEK / ERK pathway is found to be important in regulating different biological processes such as proliferation, differentiation and survival a wide variety of cells. However, its role self‐renewal haematopoietic stem cells controversial remains clarified. aim this study was understand the ex vivo expansion mononuclear ( MNC s) purified CD 34 + cells, both derived from human umbilical cord blood hUCB ). Based on our results, culturing presence an inhibitor pathway— PD 0325901...
Abstract Introduction The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed diffusion tensor imaging changes in white matter structure. Methods Males females aged 4 14 years old spastic CP were included. Eligible participants allocated 4:1 ratio be experimental or control groups; respectively. Individuals who assigned UCB-MNC group tested...
Contribution of platelets in tissue regeneration and their possible application regenerative medicine, which is primarily mediated via secretion granular components following platelet activation, has been well established the recent decades. Therefore, rich plasma (PRP), as a portion with higher concentrations than baseline level, now an attractive therapeutic option various medical fields mainly for repair injuries. Burn injuries are devastating trauma high rate morbidities affecting...
Deep skin wounds require grafting with a substitute for treatment. Despite many attempts in the development of an affordable and efficient substitute, repair deep still remains challenging. In current study, we present 3D sponge composite made from human placenta (a disposable organ) sodium alginate exceptional properties tissue engineering applications. Toward this goal, different proportions (Alg) decellularized scaffold (DPS) were composited freeze-dried to generate desired biomechanical...
One of the main approaches to preventing skin ageing is protect fibroblast cells from oxidative stress. The promoting effect human amniotic membrane extract (hAME) on re-epithelization, proliferation and migration in wound healing has been already well studied. This experimental study aimed investigate antioxidant activity hAME against hydrogen peroxide (H2 O2 )-induced dermal damage.Here, establish model, foreskin fibroblasts (HFFs) were exposed 200 μM H2 for 2 h. HFFs treated with 0.1...
Ex vivo expansion is a promising strategy to overcome the low number of human umbilical cord blood hematopoietic stem cells (hUCB-HSCs). Although based on obtained results in unnatural physiological condition irradiated genetically immune-deficient mouse models, there has always been concern that expanded have less engraftment potential. The purpose this study was investigate effect common ex method potential hUCB-mononuclear (MNCs), using normal fetal mouse, as model with more similarity...
Abstract Background Small molecule compounds have been well recognized for their promising power in the generation, expansion, and maintenance of embryonic or adult stem cells. The aim this study was to identify a novel combination small molecules order optimize ex vivo expansion umbilical cord blood-derived CD34 + Methods Considering most important signaling pathways involved self-renewal hematopoietic cells, CB-CD34 cells were expanded with cytokines presence seven including SB, PD, Chir,...
Background: Leishmaniasis is currently considered a re-emerging or emerging infection based on the geographic region. The outcome of leishmaniasis vastly depends Leishmania-host interaction. This preliminary study aimed to show association human leukocyte antigen (HLA) class I and II genes with healed non-healed cutaneous (CL), symptomatic asymptomatic visceral (VL) compared control groups in Iran. Methods: Ninety-five people, including 31 patients versus 64 individuals group, were enrolled....
Abstract Introduction Umbilical cord blood (UCB) is a novel treatment for cerebral palsy (CP) with clinical trials indicating UCB safe and can improve gross motor function. However, heterogeneity across research design, participant selection protocols has limited the ability to interpret overall effect, identify best responders dosing thresholds. Objectives We sought conduct systematic review individual data meta-analysis (IPDMA) 1) determine effect of measured by Gross Motor Function...