A5017437592- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Nerve injury and regeneration
- Sperm and Testicular Function
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Forensic Anthropology and Bioarchaeology Studies
- Effects of Radiation Exposure
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Curcumin's Biomedical Applications
- Fatty Acid Research and Health
- Innovations in Medical Education
- Neurological Disease Mechanisms and Treatments
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Wound Healing and Treatments
- Neurological Disorders and Treatments
- Phytoestrogen effects and research
Tehran University of Medical Sciences
2016-2025
Vrije Universiteit Brussel
2004-2023
University of Tehran
2007-2023
Iranian Legal Medicine Organization
2020-2021
Indiana University School of Medicine
2020
Islamic Azad University Bandar Abbas
2020
May Institute
2016
Fundación Juan March
2016
Clinical Research Organization
2014
Vlaams Instituut voor Biotechnologie
2002
It is well accepted that the success of mesenchymal stem cells (MSCs) therapy against experimental stroke mainly due to cellular paracrine manners rather than replace lost tissue per se. Given such "bystander" effects, cell-free therapeutics manifest as a promising approach in regenerative medicine. Here we aimed at evaluating effect conditioned medium (CM) derived from human embryonic MSCs (hESC-MSC) on neurological deficit, neurogenesis, and angiogenesis stroke. Adult male Wistar rats...
Abstract Background The beneficial effects of curcumin which includes its antioxidant, anti-inflammatory and cancer chemo-preventive properties have been identified. Little information is available regarding the optimal dose treatment periods on proliferation rate different sources stem cells. Methods In this study, effect various concentrations survival two types outstanding cells bone marrow (BMSCs) adult rat neural stem/progenitor (NS/PCs) at time points was investigated. BMSCs were...
Cucurbita moschata Duchesne (pumpkin) is a well-known plant with several pharmacological effects. The aim of the present study was to assess burn wound healing activity C. peel extract (CE). Also, standardized CE assessed for antioxidant and antibacterial effects against major pathogens burns.Healing properties topical preparation 10% 20% concentrations were on second degree in rats during 14-day period as well histological studies, total power, lipid peroxidation thiol content skin tissue...
Abstract In the context of treating spinal cord injury (SCI), modulation inflammatory responses, and creation a suitable region for tissue regeneration may present promising approach. This study aimed to evaluate effects curcumin (Cur)‐loaded bovine serum albumin nanoparticles (Cur‐BSA NPs) cross‐linked with an acellular scaffold (ASCS) on functional recovery in rat model SCI. We developed ASCS using chemical physical methods. Cur‐BSA, blank (B‐BSA) NPs were fabricated via EDC‐NHS, resulting...
Inflammatory responses and oxidative stress (OS) play a significant role in the development of spinal cord injury (SCI), as evidenced by both pre-clinical clinical studies. This research aimed to assess potential antioxidant anti-inflammatory properties curcumin (CuC) therapeutic approach unilateral SCI model using male rats. We used 40 adult Wistar rats (each weighing 220 – 250 g) that were randomly assigned one five experimental groups: (1) Control (Con), (2) Model (SCI animals),...
Ischemic stroke is a common leading cause of death and disability with lack effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression protein concentration brain-derived neurotrophic factor (BDNF) Glial cell-derived (GDNF) in hippocampal CA1 region rat model brain ischemia/reperfusion (I/R). transient middle cerebral artery occlusion (tMCAo) used as ischemic stroke. Rats were randomly divided four groups Co, Sh, tMCAo + T3. Then, single dose...
In the present study, multilayer electrospun chitosan-based dressing containing Semellil extract (ANGIPARS ™) was fabricated and evaluated as wound dressing. The first layer polyurethane nanofibers which used a protective layer, middle chitosan loaded with third mat, applied to improve sustained release of order increase stability dressings in physiological environment genipin, crosslink nanofibers. So FE-SEM images indicated genipin cross-linked after immersion PBS. addition, mats were...
Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for plant. The aim this study was to assess wound healing activity standardized extract T. (TG) aerial parts. Topical TG with 5% 10% concentrations eucerine base assessed its properties on second degree burn rats during 14-day period. Biomarkers oxidative damage including total...