A5001612039- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Anesthesia and Neurotoxicity Research
- RNA Research and Splicing
- Virus-based gene therapy research
- RNA modifications and cancer
- Immune Response and Inflammation
- Parkinson's Disease Mechanisms and Treatments
- Spinal Cord Injury Research
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- 3D Printing in Biomedical Research
- RNA regulation and disease
- Nanoplatforms for cancer theranostics
University of Cambridge
2016-2025
National Institute for Health Research
2013-2025
Cambridge University Hospitals NHS Foundation Trust
2024
Imperial College London
2024
Amirkabir University of Technology
2023
Universal Scientific Education and Research Network
2023
University of Ottawa
2023
Universitat de València
2023
Stem Cell Institute
2018-2020
Wellcome/MRC Cambridge Stem Cell Institute
2011-2019
Extracellular vesicles (EVs) are membraneous released by a variety of cells into their microenvironment. Recent studies have elucidated the role EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, as possible reservoirs biomarkers. These findings generated immense interest, along with an exponential increase molecular data pertaining to EVs. Here, we describe Vesiclepedia, manually curated compendium (lipid, RNA, protein) identified different classes...
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types participate in physiological pathophysiological processes. EVs mediate intercellular communication cell‐derived extracellular signalling organelles that transmit specific information from their of origin to target cells. As a result these properties, defined may serve novel tools for various therapeutic approaches, including (a) anti‐tumour therapy, (b) pathogen vaccination, (c)...
Although macrophages (MPhi) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The difficulties distinguishing between different MPhi subpopulations at the lesion site have further contributed controversy and led common view functionally homogenous. Given massive accumulation injured activated resident microglia, which native immune occupants central nervous system (CNS), recruitment additional infiltrating...
Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in animal models with delayed neuronal death via a number of indirect bystander effects. A comprehensive knowledge how transplanted NPCs exert their therapeutic effects is still lacking. Here, we investigated the transplantation adult syngenic NPCs--injected intravenously 72 h after transient middle cerebral artery occlusion--on neurological recovery, histopathology and gene expression. NPC-transplanted mice...
ABSTRACT Bioinformatics tools are imperative for the in depth analysis of heterogeneous high‐throughput data. Most software developed by specific laboratories or groups companies wherein they designed to perform required group. However, such may fail capture “what community needs a tool”. Here, we describe novel community‐driven approach build comprehensive functional enrichment tool. Using existing FunRich tool as template, invited researchers request additional features and/or changes....
Neural stem cell (NSC) transplantation can influence immune responses and suppress inflammation in the CNS. Metabolites, such as succinate, modulate phenotype function of cells, but whether how NSCs are also activated by immunometabolites to control immunoreactivity inflammatory is unclear. Here, we show that transplanted somatic directly induced ameliorate chronic CNS reducing succinate levels cerebrospinal fluid, thereby decreasing mononuclear phagocyte (MP) infiltration secondary damage....
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement lost endogenous cells was originally proposed as primary healing mechanism NSC grafts, it is now clear that transplanted NSCs operate via multiple mechanisms, including horizontal exchange therapeutic cargoes to host extracellular vesicles (EVs). EVs are membrane particles trafficking nucleic acids, proteins, metabolites and metabolic enzymes, lipids,...
Abstract Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark several chronic neurological diseases, including multiple sclerosis 1 . Distinct metabolic and mitochondrial features guide the activation diverse functional states 2 However, how these act to perpetuate inflammation central nervous system unclear. Here, using multiomics approach, we identify molecular signature that sustains microglia through complex I activity driving reverse electron transport...
The well regulated activities of microglia and T cells specific to central nervous system (CNS) antigens can contribute the protection CNS neural their renewal from adult stem/progenitor (aNPCs). Here we report that cell-based vaccination mice with a myelin-derived peptide, when combined transplantation aNPCs into cerebrospinal fluid (CSF), synergistically promoted functional recovery after spinal cord injury. synergistic effect was correlated modulation nature intensity local cell...
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity endogenous brain stem cell compartment in chronic CNS disorders remains poorly characterized. Here we show persistent inflammation, induced by immune...
Transplanted neural stem/precursor cells possess peculiar therapeutic plasticity and can simultaneously instruct several mechanisms in addition to cell replacement. Here, we interrogated the of after their focal implantation severely contused spinal cord. We injected syngeneic at proximal distal ends mouse cord analysed locomotor functions relevant secondary pathological events mice, fate transplanted cells, gene expression inflammatory infiltration injured site. used two different doses...
Transplanted neural stem/precursor cells (NPCs) display peculiar therapeutic plasticity in vivo. Although the replacement of was first expected as prime mechanism stem regenerative medicine, it is now clear that transplanted NPCs simultaneously instruct several mechanisms, among which might not necessarily prevail. A comprehensive understanding mechanism(s) by exert their lacking. This study designed a preclinical approach to test feasibility human NPC transplantation an outbreed nonhuman...
Abstract Background Dopamine-synthesizing (dopaminergic, DA) neurons in the ventral midbrain (VM) constitute a pivotal neuronal population controlling motor behaviors, cognitive and affective brain functions, which generation critically relies on activation of Wingless-type MMTV integration site (Wnt)/β-catenin pathway their progenitors. In Parkinson's disease, DA cell bodies within substantia nigra pars compacta (SNpc) progressively degenerate, with causes mechanisms poorly understood....
Extracellular vesicles (EVs) are the collective term for various that released by cells into extracellular space. Such include exosomes and microvesicles, which vary their size and/or protein genetic cargo. With discovery EVs contain material in form of RNA (evRNA) has come increased interest these potential use as sources disease biomarkers therapeutic agents. Rapid developments availability deep sequencing technologies have enabled study EV‐related detail. In October 2012, International...