A5032645016- Extracellular vesicles in disease
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Microbial metabolism and enzyme function
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Management of metastatic bone disease
- Wnt/β-catenin signaling in development and cancer
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Lymphatic System and Diseases
Centro de Investigación del Cáncer
2016-2025
Spanish National Cancer Research Centre
2016-2025
CIC bioGUNE
2025
Centro Nacional de Epidemiología
2019-2023
Molecular Oncology (United States)
2019-2022
Cancer Research Center
2019-2022
Universidad Alfonso X el Sabio
2022
RELX Group (Netherlands)
2021
Cornell University
2010-2019
Children's Cancer and Blood Foundation
2012-2019
Transcriptional repression mechanisms have emerged as one of the crucial processes for downregulation E-cadherin expression during development and tumour progression. Recently, several transcriptional repressors been characterized (Snail, E12/E47, ZEB-1 SIP-1) shown to act through an interaction with proximal E-boxes promoter. We analyzed participation another member Snail family, Slug, observed that it also behaves a repressor expression. Stable Slug in MDCK cells leads full at level...
The transcription factor Snail has been described as a direct repressor of E-cadherin expression during development and carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown. Here we show that mammalian requires histone deacetylase (HDAC) activity to repress promoter treatment with trichostatin A (TSA) is sufficient block effect Snail. Moreover, overexpression correlated deacetylation histones H3 H4 at promoter, TSA Snail-expressing cells reverses...
The Snail transcription factor has been described recently as a strong repressor of E-cadherin in epithelial cell lines, where its stable expression leads to the loss and induces epithelial-mesenchymal transitions an invasive phenotype. mechanisms regulating development tumor progression are not yet known. We show here that transforming growth beta-1 (TGFbeta1) Madin-Darby canine kidney cells triggers by mechanism dependent on MAPK signaling pathway. Furthermore, TGFbeta1 activity promoter,...
Epithelial-mesenchymal transition (EMT) is important during embryonic cell layer movement and tumor invasiveness. EMT converts adherent epithelial cells to motile mesenchymal cells, favoring metastasis in the context of cancer progression. Transforming growth factor-beta (TGF-beta) triggers via intracellular Smad transducers other signaling proteins. We previously reported that high mobility group A2 (HMGA2) gene required for TGF-beta elicit mammary cells. In present study we investigated...
ABSTRACT Bioinformatics tools are imperative for the in depth analysis of heterogeneous high‐throughput data. Most software developed by specific laboratories or groups companies wherein they designed to perform required group. However, such may fail capture “what community needs a tool”. Here, we describe novel community‐driven approach build comprehensive functional enrichment tool. Using existing FunRich tool as template, invited researchers request additional features and/or changes....
Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal billions cells, but its mechanisms consequences within living tissues poorly defined. Using a parabiosis-based strategy, we identified isolated from multiple as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated mediated distinct repertoires receptors,...
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed remain free these cells and protected from their toxic cargo. Here, we show that endowed with multiple tissues steady-state, a process follows tissue-specific dynamics. By focusing two particular intestine lungs, find infiltrating engulfed by resident macrophages, resulting repression Il23 transcription, reduced G-CSF plasma, reinforced activity distant bone...
Senescence is a cellular phenotype present in health and disease, characterized by stable cell-cycle arrest an inflammatory response called senescence-associated secretory (SASP). The SASP important influencing the behavior of neighboring cells altering microenvironment; yet, this role has been mainly attributed to soluble factors. Here, we show that both factors small extracellular vesicles (sEVs) are capable transmitting paracrine senescence nearby cells. Analysis individual internalizing...