A5078030451- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Meningioma and schwannoma management
- Metabolomics and Mass Spectrometry Studies
- Parkinson's Disease Mechanisms and Treatments
- Immune cells in cancer
- Amyotrophic Lateral Sclerosis Research
- Studies on Chitinases and Chitosanases
- Ubiquitin and proteasome pathways
- Lysosomal Storage Disorders Research
- Genetic Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Cellular transport and secretion
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Medicinal Plants and Neuroprotection
- Tryptophan and brain disorders
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Neurological Disease Mechanisms and Treatments
University of Cambridge
2023-2024
Imperial College London
2020-2024
NIHR Imperial Biomedical Research Centre
2024
University College London
2021-2022
National Hospital for Neurology and Neurosurgery
2021-2022
King's College London
2022
University of Toronto
2020
St. Michael's Hospital
2018-2019
Abstract Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark several chronic neurological diseases, including multiple sclerosis 1 . Distinct metabolic and mitochondrial features guide the activation diverse functional states 2 However, how these act to perpetuate inflammation central nervous system unclear. Here, using multiomics approach, we identify molecular signature that sustains microglia through complex I activity driving reverse electron transport...
Abstract GBA variants carriers are at increased risk of Parkinson’s disease (PD) and Lewy body dementia (LBD). The presence pseudogene GBAP1 predisposes to structural variants, complicating genetic analysis. We present two methods resolve recombinant alleles other in : Gauchian, a tool for short-read, whole-genome sequencing data analysis, Oxford Nanopore after PCR enrichment. Both were concordant 42 samples carrying range recombinants -related mutations, Gauchian outperformed the GATK Best...
This study examined dark microglia-a state linked to central nervous system pathology and neurodegeneration-during postnatal development in the mouse ventral hippocampus, finding that microglia interact with blood vessels synapses perform trogocytosis of pre-synaptic axon terminals. Furthermore, we found notably expressed C-type lectin domain family 7 member A (CLEC7a), lipoprotein lipase (LPL) triggering receptor on myeloid cells 2 (TREM2) required TREM2, differently from other microglia,...
Abstract BACKGROUND Meningiomas are the most common tumors occurring in central nervous system, with variable recurrence rates depending on World Health Organization grading. Atypical (Grade II) meningioma has a higher rate of than benign I) meningioma. The efficacy adjuvant radiotherapy (RT) to improve tumor control been questioned. OBJECTIVE To investigate clinical and histopathological predictors radio-resistance atypical meningiomas. METHODS This cohort study retrospectively reviewed all...
Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Despite increasing evidence of the importance metabolic dysregulation in AD, underlying changes that may impact amyloid plaque formation are not understood, particularly for late-onset AD. This study analyzed genome-wide association studies (GWAS), transcriptomics, and proteomics data obtained from several repositories to obtain differentially expressed (DE) multi-omics elements mouse models We characterized...
Abstract Background Somatic α‐synuclein ( SNCA ) copy number variants (CNVs, specifically gains) occur in multiple system atrophy (MSA) and Parkinson's disease brains. Objective The aim was to compare somatic CNVs MSA subtypes (striatonigral degeneration [SND] olivopontocerebellar [OPCA]) correlate with inclusions. Methods We combined fluorescent situ hybridization immunofluorescence for some cases oligodendrocyte marker tubulin polymerization promoting protein (TPPP). Results analyzed one...
Functional and pathological recovery after spinal cord injury (SCI) is often incomplete due to the limited regenerative capacity of central nervous system (CNS), which further impaired by several mechanisms that sustain tissue damage. Among these, chronic activation immune cells can cause a persistent state local CNS inflammation However, this maladaptive response in SCI have not been fully clarified yet. In study, we integrated histological analyses with proteomic, lipidomic,...
Aberrant motor behavior (AMB) is a neuropsychiatric symptom (NPS) prevalent in Alzheimer's disease (AD), known to cause great distress both patients and caregivers. Apolipoprotein E4 (APOE4) the most important genetic predictor of AD, it has been associated with high NPS prevalence.To investigate neuropathological substrates risk factors AMB AD patients.Cases Braak stage I-II CERAD 0-1 were classified as Low (LAD), while III-IV 2 grouped Intermediate (IAD). Cases V-VI 3 High (HAD) accordance...
Ischemic stroke results in a loss of tissue homeostasis and integrity, the underlying pathobiology which stems primarily from depletion cellular energy stores perturbation available metabolites 1 . Hibernation thirteen-lined ground squirrels (TLGS), Ictidomys tridecemlineatus , provides natural model ischemic tolerance as these mammals undergo prolonged periods critically low cerebral blood flow without evidence central nervous system (CNS) damage 2 Studying complex interplay genes that...
Small, Ubiquitin-like Modifier (SUMO) is a post-translational modifier with profound influence on several key biological processes including the mammalian stress response. Of particular interest its neuroprotective effects, first recognized in 13-lined ground squirrel (Ictidomys tridecemlineatus), context of hibernation torpor. Although full scope SUMO pathway yet to be elucidated, observations importance managing neuronal responses ischemia, maintaining ion gradients, and preconditioning...
Abstract Background Alzheimer’s disease (AD) is the most prevalent form of dementia in elderly. AD has no cure but symptomatic treatment, thus, an effective therapy urgently needed. Previously our laboratory we have explored potential neuroprotective effects coactivator for peroxisome proliferator‐activated receptor‐γ (PPARγ), ‐PGC‐1α mainly involved regulation metabolic processes and mitochondrial biogenesis. PGC‐1α been shown to be different neurodegenerative diseases its expression...
Abstract GBA variants cause the autosomal recessive Gaucher disease, and carriers are at increased risk of Parkinson’s disease (PD) Lewy body dementia (LBD). The presence a highly homologous nearby pseudogene ( GBAP1 ) predisposes to range structural arising from either gene conversion or reciprocal recombination, latter resulting in copy number gains losses, complicating genetic testing analysis. To date, short-read sequencing has not been able fully resolve these other key homology region,...
Abstract Alzheimer’s Disease (AD) is a highly prevalent neurodegenerative disorder. Despite increasing evidence of important metabolic dysregulation in AD, the underlying changes that may impact amyloid plaque formation are not understood, particularly for late onset AD. This study analyzed genome-wide association studies (GWAS), transcriptomics and proteomics data obtained from several repositories to obtain differentially expressed (DE) multi-omics elements mouse models We characterized...
The e4 allele of the APOE gene is Alzheimer's Disease (AD) main genetic risk factor in population. In addition, it has been associated with both neuropsychological symptoms and AD comorbid neuropathology such as Lewy Bodies (LB). Aberrant Motor Behaviour (AMB) a neuropsychiatric symptom clinically characterized by repetitive actions, irregular pacing overall inability to keep still. Despite being fairly common among diagnosed patients, factors underlying AMB's incidence are poorly...
The e4 allele of the APOE gene is strongest genetic predictor Alzheimer's Disease (AD). APOE4 has been independently associated with neuropsychiatric symptoms prevalence and comorbid neuropathology such as Lewy Bodies (LB) Cerebral Amyloid Angiopathy (CAA). Aberrant Motor Behaviour (AMB) a symptom clinically characterized by repetitive actions, irregular pacing inability to keep still. Despite being fairly common among AD patients, neuropathological substrates underlying AMB are poorly...
Abstract BACKGROUND Meningiomas are the most common tumors in central nervous system, with variable recurrence rates depending on WHO grading. Atypical (WHO grade II) meningioma has a higher rate than benign I). The efficacy of adjuvant radiotherapy (RT) to improve tumor control been questioned. METHODS This cohort study retrospectively reviewed all patients at St. Michaels Hospital Tumor Patient Database diagnosis atypical (AM) who underwent surgical resection between 1995 and 2015....
Sunday, April 26April 14, 2020Free AccessCombined Necrosis and Brain Invasion Predict Radio-resistance Tumor Reoccurrence in Atypical Meningioma (2325)Monica Emili Garcia-Segura, Rishi Jairath, David Munoz, Sunit DasAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.2325 Letters to the Editor