A5076795620- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Advanced MRI Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Metabolism and Genetic Disorders
- Advanced NMR Techniques and Applications
- Lipid metabolism and biosynthesis
- Gut microbiota and health
- Eicosanoids and Hypertension Pharmacology
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Sensor Technologies
- Muscle metabolism and nutrition
- Bioinformatics and Genomic Networks
- Analytical Chemistry and Chromatography
University of Cambridge
2016-2025
University of Aberdeen
2021-2025
MRC Human Nutrition Research
2013-2024
Imperial College London
2003-2024
Czech Academy of Sciences, Biology Centre
2024
International Severe Acute Respiratory and Emerging Infection Consortium
2023
Instituto Alexander Fleming
2023
Hammersmith Hospital
2021-2022
UK Dementia Research Institute
2020-2022
Ipsen (France)
2022
MetaboLights (http://www.ebi.ac.uk/metabolights) is the first general-purpose, open-access repository for metabolomics studies, their raw experimental data and associated metadata, maintained by one of major providers in molecular biology. Metabolomic profiling an important tool research into biological functioning systemic perturbations caused diseases, diet environment. The effectiveness such methods depends on availability public open across a broad range conditions. repository, powered...
Human induced pluripotent stem (iPS) cells hold great promise for advancements in developmental biology, cell-based therapy, and modeling of human disease. Here, we examined the use iPS inherited metabolic disorders liver. Dermal fibroblasts from patients with various diseases liver were used to generate a library patient-specific cell lines. Each line was differentiated into hepatocytes using what believe be novel 3-step differentiation protocol chemically defined conditions. The resulting...
A challenging task in the study of secretory pathway is identification and localization new proteins to increase our understanding functions different organelles. Previous proteomic studies endomembrane system have been hindered by contaminating proteins, making it impossible assign Here we used organelle isotope tagging technique conjunction with tags for relative absolute quantitation 2D liquid chromatography simultaneous assignment multiple subcellular compartments. With this approach,...
Abstract Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark many cancers. However, the precise molecular composition lipids tumors remains generally poorly characterized. The aim present study was to analyze global profiles breast cancer, integrate results protein expression, validate findings by functional experiments. Comprehensive lipidomics conducted 267 human tissues using ultraperformance liquid chromatography/ mass spectrometry. products de novo...
To make full use of research data, the bioscience community needs to adopt technologies and reward mechanisms that support interoperability promote growth an open 'data commoning' culture. Here we describe prerequisites for data commoning present established growing ecosystem solutions using shared 'Investigation-Study-Assay' framework vision.
Type 2 diabetes mellitus is the result of a combination impaired insulin secretion with reduced sensitivity target tissues. There are an estimated 150 million affected individuals worldwide, whom large proportion remains undiagnosed because lack specific symptoms early in this disorder and inadequate diagnostics. In study, NMR-based metabolomic analysis conjunction multivariate statistics was applied to examine urinary metabolic changes two rodent models type as well unmedicated human...
Inflammatory bowel disease (IBD) is a chronic inflammatory of the gastrointestinal tract uncertain origin, which includes ulcerative colitis (UC) and Crohn's (CD). The composition gut microbiota may change in IBD affected individuals, but whether dysbiosis cause or consequence processes intestinal tissue still unclear. Here, metabolites stool 183 subjects (82 UC, 50 CD, 51 healthy controls) were determined. content microbiological profiles significantly different between subjects. In group,...
A critical question facing the field of metabolomics is whether data obtained from different centers can be effectively compared and combined. An important aspect this interlaboratory precision (reproducibility) analytical protocols used. We analyzed human samples in six laboratories using instrumentation but a common protocol (the AbsoluteIDQ p180 kit) for measurement 189 metabolites via liquid chromatography (LC) or flow injection analysis (FIA) coupled to tandem mass spectrometry (MS/MS)....