Carlos A. González
A5103259750- Nutritional Studies and Diet
- Cancer Risks and Factors
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Nutrition, Genetics, and Disease
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Obesity, Physical Activity, Diet
- Consumer Attitudes and Food Labeling
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Phytochemicals and Antioxidant Activities
- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Phytoestrogen effects and research
- Bladder and Urothelial Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Fatty Acid Research and Health
- Blood groups and transfusion
- Diet and metabolism studies
- Glutathione Transferases and Polymorphisms
- Eosinophilic Esophagitis
- Tea Polyphenols and Effects
Fundación Universitaria Sanitas
2023-2025
Hospital de Sant Pau
2023-2025
Fundación para la Investigación, Docencia y Prevención del Cáncer
2024
Hospital Muñiz
2017-2024
Centre Hospitalier du Pays d'Aix
2024
Asociación Colombiana de Gastroenterología
2023
Hospital del Mar Research Institute
2023
Universitat Pompeu Fabra
2023
University of San Carlos of Guatemala
2023
Peuplements végétaux et bioagresseurs en milieu tropical
2023
Abstract The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition cancer, with potential for studying other diseases as well. currently includes 519 978 participants (366 521 women 153 457 men, mostly aged 35–70 years) in 23 centres located 10 countries, be followed cancer incidence cause-specific mortality several decades. At enrolment, which took place 1992 2000 at...
Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish may be a decreased risk, but the existing less convincing.
Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist women. This discrepancy may be differences fat distribution between sexes the use hormone replacement therapy (HRT) women.We used multivariable adjusted Cox proportional hazards models examine association anthropometric measures risks rectal among 368 277 men women who were free at baseline from nine countries European Prospective Investigation Into Cancer...
Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids — notably androgens oestrogens promote breast tumour development. In spite of this evidence, postmenopausal androgen replacement therapy with dehydroepiandrosterone (DHEA) or testosterone has been advocated for the prevention osteoporosis improved sexual well-being. We have conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition. Levels DHEA...
It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit vegetable overall risk.We conducted a prospective analysis the European Prospective Investigation into Cancer Nutrition (EPIC) cohort assess relationships total fruits, vegetables, vegetables combined risk during 1992-2000. Detailed information on dietary habit lifestyle...
Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, both an or lack adrenal androgens (dehydroepiandrosterone [DHEA] its sulfate [DHEAS]) as risk factors. We conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition cohort to examine associations serum concentrations subsequent...
Transplantation tolerance is induced reliably in experimental animals following intrathymic inoculation with the relevant donor strain Ags; however, immunological mechanisms responsible for induction and maintenance of tolerant state remain unknown. We investigated these using TCR transgenic mice (TS1) that carry T cells specific an immunodominant, MHC class II-restricted peptide (S1) influenza PR8 hemagglutinin (HA) molecule. demonstrated TS1 reject skin grafts have transgene-encoded HA...
Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a is lacking. We examined the risks of cancer adenocarcinoma associated with meat consumption within European Prospective Investigation Into Cancer Nutrition (EPIC) cohort.A total 521,457 men women aged 35-70 years 10 countries participated EPIC cohort. lifestyle information was collected at recruitment. Cox proportional hazard models were used examine...
It is considered that fruit and vegetable (F&V) protect against oesophagus gastric cancer (GC). However, 2 recent meta-analyses suggest the strength of association on GC seems to be weaker for vegetables than in cohort case-control studies. No evidence exists from studies about adenocarcinoma (ACO). In 521,457 men women participating EPIC 10 European countries, information diet lifestyle was collected at baseline. After an average 6.5 years follow-up, a total 330 65 ACO, confirmed classified...
<h3>Background and objective</h3> About 9% of gastric carcinomas have Epstein–Barr virus (EBV) in the tumour cells, but it is unclear whether viral presence influences clinical progression. We therefore examined a large multicentre case series for association EBV status with survival after cancer diagnosis, accounting surgical stage other prognostic factors. <h3>Methods</h3> combined individual-level data on 4599 patients diagnosed between 1976 2010 from 13 studies Asia (n=8), Europe (n=3),...
Human papillomavirus type 16 (HPV16) infection is causing an increasing number of oropharyngeal cancers in the United States and Europe. The aim our study was to investigate whether HPV antibodies are associated with head neck cancer risk when measured prediagnostic sera.We identified 638 participants incident (patients; 180 oral cancers, 135 oropharynx 247 hypopharynx/larynx cancers) 300 patients esophageal as well 1,599 comparable controls from within European Prospective Investigation...
No known cohort study has investigated whether the Mediterranean diet can reduce incident coronary heart disease (CHD) events in a population. This examined relation between adherence and risk of CHD 5 Spanish centers European Prospective Investigation into Cancer Nutrition. Analysis included 41,078 participants aged 29-69 years, recruited 1992-1996 followed up until December 2004 (mean follow-up:10.4 years). Confirmed fatal nonfatal were analyzed according to adherence, measured by using an...
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...
Although several studies have investigated the association of Mediterranean diet with overall mortality or risk specific cancers, data on cancer are sparse. We examined between adherence to dietary pattern and using from European Prospective Investigation Into Cancer nutrition, a multi-centre prospective cohort study including 142 605 men 335 873. Adherence was score (range: 0–9) considering combined intake fruits nuts, vegetables, legumes, cereals, lipids, fish, dairy products, meat...
Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether association remained after longer follow-up a near threefold increase in cases, and if varied by gender tumour location.After mean of 11.0 years, 4,517 incident cases were documented. Total, cereal, fruit, vegetable intakes estimated questionnaires at baseline. Hazard ratios...
Epidemiological evidence suggests that the Mediterranean diet (MD) could reduce risk of breast cancer (BC). As from prospective studies remains scarce and conflicting, we investigated association between adherence to MD BC among 335,062 women recruited 1992 2000, in ten European countries, followed for 11 years on average. Adherence was estimated through an adapted relative (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting factors. A total...