Kay‐Tee Khaw

ORCID: 0000-0002-8802-2903
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About
Contact & Profiles
Research Areas
  • Nutritional Studies and Diet
  • Genetic Associations and Epidemiology
  • Cancer Risks and Factors
  • Cancer, Lipids, and Metabolism
  • Obesity, Physical Activity, Diet
  • Nutrition and Health in Aging
  • Bone health and osteoporosis research
  • Nutrition, Genetics, and Disease
  • Liver Disease Diagnosis and Treatment
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Vitamin D Research Studies
  • Lipoproteins and Cardiovascular Health
  • Diet and metabolism studies
  • Estrogen and related hormone effects
  • Health disparities and outcomes
  • Epigenetics and DNA Methylation
  • Fatty Acid Research and Health
  • Colorectal Cancer Screening and Detection
  • Pancreatic and Hepatic Oncology Research
  • Growth Hormone and Insulin-like Growth Factors
  • Blood Pressure and Hypertension Studies
  • Physical Activity and Health
  • Adipokines, Inflammation, and Metabolic Diseases
  • Vitamin C and Antioxidants Research
  • Folate and B Vitamins Research

University of Cambridge
2015-2024

Medical Research Council
2010-2024

University College London
2008-2024

MRC Epidemiology Unit
2013-2024

Moorfields Eye Hospital NHS Foundation Trust
2020-2024

MRC Biostatistics Unit
1989-2023

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2010-2023

University of Balamand
2018-2023

Antonine University
2023

Bridge University
2003-2022

Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Gina M. Peloso Stefan Gustafsson and 95 more Stavroula Kanoni Andrea Ganna Ming‐Huei Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Ron Do Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Cameron D. Palmer Markus Perola Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S. F. Doney Angela Döring Paul Elliott Stephen E. Epstein Guðmundur I. Eyjólfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna-Liisa Hartikainen Caroline Hayward Dena Hernández Andrew A. Hicks Hilma Hólm Yi-Jen Hung Thomas Illig Michelle R. Jones Pontiano Kaleebu John J.P. Kastelein Kay‐Tee Khaw Eric H. Kim

10.1038/ng.2797 article EN Nature Genetics 2013-10-06

Previous studies have relied predominantly on the body-mass index (BMI, weight in kilograms divided by square of height meters) to assess association adiposity with risk death, but few examined whether distribution body fat contributes prediction death.We BMI, waist circumference, and waist-to-hip ratio death among 359,387 participants from nine countries European Prospective Investigation into Cancer Nutrition (EPIC). We used a Cox regression analysis, age as time variable, stratified...

10.1056/nejmoa0801891 article EN New England Journal of Medicine 2008-11-12
Cristen J. Willer Elizabeth K. Speliotes Ruth J. F. Loos Shengxu Li Cecilia M. Lindgren and 95 more Iris M. Heid Sonja I. Berndt Amanda L. Elliott Anne Jackson Claudia Lamina Guillaume Lettre Noha Lim Helen N. Lyon Steven A. McCarroll Konstantinos Papadakis Lu Qi Joshua C. Randall Rosa Maria Roccasecca Serena Sanna Paul Scheet Michael N. Weedon Eleanor Wheeler Jing Hua Zhao Leonie C. Jacobs Inga Prokopenko Nicole Soranzo Toshiko Tanaka Nicholas J. Timpson Peter Almgren Amanda J. Bennett Richard N. Bergman Sheila Bingham Lori L. Bonnycastle Matthew A. Brown Noel L. P. Burtt Peter S. Chines Lachlan Coin Francis S. Collins John Connell Cyrus Cooper George Davey Smith Elaine Dennison Parimal Deodhar Paul Elliott Michael R. Erdos Karol Estrada David M. Evans Lauren Gianniny Christian Gieger Christopher Gillson Candace Guiducci Rachel Hackett David Hadley Alistair S. Hall Aki S. Havulinna Johannes Hebebrand Albert Hofman Bo Isomaa Kevin B. Jacobs Toby Johnson Pekka Jousilahti Z Jovanović Kay‐Tee Khaw Peter Kraft Mikko Kuokkanen Johanna Kuusisto Jaana Laitinen Edward G. Lakatta Jian’an Luan Robert Luben Massimo Mangino Wendy L. McArdle Thomas Meitinger Antonella Mulas Patricia B. Munroe Narisu Narisu Andy Ness Kate Northstone Stephen O’Rahilly Carolin Purmann Matthew G. Rees Martin Ridderstråle Susan M. Ring Fernando Rivadeneira A Ruokonen Manjinder S. Sandhu Jouko Saramies Laura J. Scott Angelo Scuteri Kaisa Silander Matthew Sims Kijoung Song Jonathan Stephens Suzanne Stevens Heather M. Stringham Y. C. Loraine Tung Timo T. Valle Cornelia M. van Duijn Karani S. Vimaleswaran Péter Vollenweider

10.1038/ng.287 article EN Nature Genetics 2008-12-14
Christopher Newton‐Cheh Toby Johnson Vesela Gateva Martin D. Tobin Murielle Bochud and 95 more Lachlan Coin Samer S. Najjar Jing Hua Zhao Simon Heath S. Eyheramendy Konstantinos A. Papadakis Benjamin F. Voight Laura J. Scott Feng Zhang Martin Farrall Toshiko Tanaka Chris Wallace John C. Chambers Kay‐Tee Khaw Peter M. Nilsson Pim van der Harst Silvia Polidoro Diederick E. Grobbee N. Charlotte Onland‐Moret Michiel L. Bots Louise V. Wain Katherine S. Elliott Alexander Teumer Jian’an Luan Gavin Lucas Johanna Kuusisto Paul R. Burton David Hadley Wendy L. McArdle Matthew A. Brown Anna F. Dominiczak Stephen Newhouse Nilesh J. Samani John Webster Eleftheria Zeggini J. Beckmann Sven Bergmann Noha Lim Kijoung Song Péter Vollenweider Gérard Waeber Dawn Waterworth Xin Yuan Leif Groop Marju Orho‐Melander Alessandra Allione Alessandra Di Gregorio Simonetta Guarrera Salvatore Panico Fulvio Ricceri Valeria Romanazzi Carlotta Sacerdote Paolo Vineis Inês Barroso Manjinder S. Sandhu Robert Luben Gabriel Crawford Jari Lahti Markus Perola Michael Boehnke Lori L. Bonnycastle Francis S. Collins Anne Jackson Karen L. Mohlke Heather M. Stringham Timo T. Valle Cristen J. Willer Richard N. Bergman Mario A. Morken Angela Döring Christian Gieger Thomas Illig Thomas Meitinger Elin Org Arne Pfeufer H.‐Erich Wichmann Sekar Kathiresan Jaume Marrugat Christopher J. O’Donnell Stephen M. Schwartz David S. Siscovick Isaac Subirana Nelson B. Freimer Anna-Liisa Hartikainen Mark I. McCarthy Paul F. O’Reilly Leena Peltonen Anneli Pouta Paul E. de Jong Harold Snieder Wiek H. van Gilst Robert Clarke Anuj Goel Anders Hamsten John F. Peden

10.1038/ng.361 article EN Nature Genetics 2009-05-10

Context-Data regarding the association between subclinical hypothyroidism and cardiovascular disease outcomes are conflicting among large prospective cohort studies.This might reflect differences in participants' age, sex, thyroid-stimulating hormone (TSH) levels, or preexisting disease.Objective-To assess risks of coronary heart (CHD) total mortality for adults with hypothyroidism. Data Sources StudySelection-The databases MEDLINE EMBASE (1950 to May 31, 2010) were searched without language...

10.1001/jama.2010.1361 article EN JAMA 2010-09-21

There is debate about the value of assessing levels C-reactive protein (CRP) and other biomarkers inflammation for prediction first cardiovascular events.We analyzed data from 52 prospective studies that included 246,669 participants without a history disease to investigate adding CRP or fibrinogen conventional risk factors risk. We calculated measures discrimination reclassification during follow-up modeled clinical implications initiation statin therapy after assessment fibrinogen.The...

10.1056/nejmoa1107477 article EN New England Journal of Medicine 2012-10-03

Background: Increasing evidence suggests a continuous relationship between blood glucose concentrations and cardiovascular risk, even below diagnostic threshold levels for diabetes. Objective: To examine the hemoglobin A1c, disease, total mortality. Design: Prospective population study. Setting: Norfolk, United Kingdom. Participants: 4662 men 5570 women who were 45 to 79 years of age residents Norfolk. Measurements: Hemoglobin A1c disease risk factors assessed from 1995 1997, events...

10.7326/0003-4819-141-6-200409210-00006 article EN Annals of Internal Medicine 2004-09-21
Ron Do Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Chi Gao and 95 more Gina M. Peloso Stefan Gustafsson Stavroula Kanoni Andrea Ganna Jin Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Colin N. A. Palmer Markus Perola Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S. F. Doney Angela Döring Paul Elliott Stephen E. Epstein Guðmundur I. Eyjólfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna-Liisa Hartikainen Caroline Hayward Dena Hernandez Andrew A. Hicks Hilma Hólm Yi-Jen Hung Thomas Illig Michelle R. Jones Pontiano Kaleebu John J.P. Kastelein Kay‐Tee Khaw

10.1038/ng.2795 article EN Nature Genetics 2013-10-06

There is overwhelming evidence that behavioural factors influence health, but their combined impact on the general population less well documented. We aimed to quantify potential of four health behaviours mortality in men and women living community.We examined prospective relationship between lifestyle a study 20,244 aged 45-79 y with no known cardiovascular disease or cancer at baseline survey 1993-1997, community United Kingdom, followed up 2006. Participants scored one point for each...

10.1371/journal.pmed.0050012 article EN cc-by PLoS Medicine 2008-01-02

<h3>Abstract</h3> <b>Objective</b> To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. <b>Design</b> Multicentre, prospective cohort study. <b>Setting</b> Nine European countries (Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden, United Kingdom). <b>Participants</b> 74 607 men and women, aged 60 or more, without coronary heart disease,...

10.1136/bmj.38415.644155.8f article EN BMJ 2005-04-08

Women ( n 160) aged 50 to 65 years were asked weigh their food for 4 d on four occasions over the period of 1 year, using PETRA (Portable Electronic Tape Recorded Automatic) scales. Throughout they complete seven other dietary assessment methods: a simple 24 h recall, structured recall with portion size assessments photographs, two food-frequency questionnaires, 7 estimated record or open-ended diary, (menu) record, and sizes assessed photographs. Comparisons between average 16 weighed...

10.1079/bjn19940064 article EN British Journal Of Nutrition 1994-10-01

Background— The relation between endogenous testosterone concentrations and health in men is controversial. Methods Results— We examined the prospective relationship mortality due to all causes, cardiovascular disease, cancer a nested case-control study based on 11 606 aged 40 79 years surveyed 1993 1997 followed up 2003. Among those without prevalent or 825 who subsequently died were compared with control group of 1489 still alive, matched for age date baseline visit. Endogenous at...

10.1161/circulationaha.107.719005 article EN Circulation 2007-11-27

It has been postulated that dehydroepiandrosterone (DHEA) and its sulfate ester, (DHEAS), the major secretory products of human adrenal gland, may be discriminators life expectancy aging. We examined relation base-line circulating DHEAS levels to subsequent 12-year mortality from any cause, cardiovascular disease, ischemic heart disease in a population-based cohort 242 men aged 50 79 years at start study. Mean decreased with age were also significantly lower history than those without such...

10.1056/nejm198612113152405 article EN New England Journal of Medicine 1986-12-11
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