A5101408930- Bariatric Surgery and Outcomes
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Diet, Metabolism, and Disease
- Obesity and Health Practices
- Body Contouring and Surgery
- Inhalation and Respiratory Drug Delivery
- Abdominal Trauma and Injuries
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal Cancer Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Tissue Engineering and Regenerative Medicine
- Pelvic and Acetabular Injuries
- Nutrition and Health in Aging
- Alcohol Consumption and Health Effects
- Cellular Mechanics and Interactions
- Gastrointestinal disorders and treatments
- Telomeres, Telomerase, and Senescence
- Trauma Management and Diagnosis
Monash University
2015-2025
The Alfred Hospital
2010-2025
Alfred Health
2019-2024
Moderna Therapeutics (United States)
2022
University of Leicester
1989-2013
Princess Margaret Hospital for Children
2005
Leicester College
2003
The University of Western Australia
1998-2000
University of Szeged
2000
Dandenong Hospital
1999
Objective To investigate the nature and duration of clinical instability (ie, abnormalities in simple physical observations or laboratory test results) hospital patients before a "critical event" cardiac arrest an unplanned admission to intensive care). Design Retrospective survey medical records all having critical events (CEs) over 12 months. Data on Intensive Care Unit (ICU) were obtained for comparison with study population. Setting A 300-bed metropolitan teaching seven-bed ICU. Patients...
<h3>Abstract</h3> <b>Objective</b>: To assess whether mini flow meters used to measure peak expiratory can track changes in lung function and indicate clinically important changes. <b>Design</b>: Comparison of measurements with a spirometer different brands meter;the were allocated subjects haphazardly. <b>Subjects</b>: 12 boys asthma aged 11 17 attending boarding school. Main outcome measures - Peak measured twice daily for three months at least one four meter. <b>Results</b>: The relation...
Summary Background It is widely held that in vitro T cell responses to allergens are more prominent atopic than normal individuals, though this conclusion based upon culture techniques which fail detect proliferative a significant minority of atopies and many normals. Objectives: Study allergen‐specific cells cultured serum‐free medium (SFM). Examine associations between status, age reactivity. Methods Initially, peripheral blood mononuclear were stimulated with or antigens SFM, compared...
Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations an important part gene discovery process. This study investigated linkage microsatellite markers 5q 11q regions asthma-associated quantitative traits 121 Australian Caucasian nuclear families. The families were recruited on basis child proband: cohort 95 randomly unselected probands (n = 442 subjects) 26 selected severe symptomatic asthma 134 subjects). assessed...
The results of 373 infrainguinal bypass grafts, in a single centre, between 1980 and 1988 are reviewed. One hundred thirty situ vein (ISV), 47 reversed saphenous (RSV), 118 polytetrafluoroethylene (PTFE) 78 human umbilical (HUV) grafts were used. indications for surgery disabling claudication 25 per cent patients limb salvage 75 cent. In 36 operations the distal anastomosis was above knee 64 it below knee. Overall 5-year patency rates respectively were, ISV (41 69 cent), RSV (62 90 PTFE (31...
Abstract Cytoplasmic microtubules and axial unit tubules were studied in both sectioned negatively‐stained material. Walls of frog lung‐fluke ( Haematoloechus medioplexus ) spermatozoa have a helical substructure, while those the flagellate, Trypanosoma lewisi , are composed ten longitudinally‐oriented filaments. Cross‐bridges occur between some filaments trypanosome microtubules. Doublet units cell types structurally similar to microtubules, which may indicate similarity function....
Background Endoscopic vacuum‐assisted closure ( EndoVAC ) therapy is a recent innovation described for use in upper gastrointestinal perforations and leaks, with reported success of 80–90%. It provides sepsis control collapses the cavity preventing stasis, encouraging healing defect. Whilst promising, initial reports this new technique have not established clear indications, feasibility optimal technique. Methods We analysed all patients who underwent between 2014 2016. The involved standard...
Adipocyte metabolism varies depending on anatomical location and the adipocyte protein composition may orchestrate this heterogeneity. We used SWATH proteomics in patient-matched human upper- (visceral subcutaneous) lower-body (glutealfemoral) adipocytes detected 4,220 proteins distinguishable regional proteomes. Upper-body were associated with glycolysis, de novo lipogenesis, mitochondrial dysfunction, oxidative stress, whereas enhanced PPARα activation, fatty acid, BCAA oxidation, TCA...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is generally asymptomatic in the early stages but, without appropriate intervention, it can progress to severe morbidities. To elucidate molecular mechanisms of development MASLD, we performed transcriptomic analysis on biopsies and metabolomic plasma samples from 109 obese individuals with no pathology or MASLD. The metabolome remodeled by parenchymal accumulation neutral lipids, whereas displayed little differences....
Obesity is a major risk factor for metabolic-associated steatotic liver disease (MASLD), which can progress to steatohepatitis (MASH). There are no validated non-invasive tests stratify persons with obesity greater MASH. Herein, we assess plasma and from 266 obese individuals spanning the MASLD spectrum. Ninety-six human livers were precision-cut, mass spectrometry-based proteomics identifies 3,333 proteins in liver-secretion medium, of 107 differentially secreted MASH compared pathology....
Background A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have resting QTc and are more likely than men to develop drug-induced prolongation. Recent studies shown association between a common variant (rs10494366) the NOS1 regulator, NOS1AP. We investigated rs10494366 in NOS1AP QTc, assessed gender-specific associations during rest after exercise. Methods SNP 919 women 918 from 504 representative families UK GRAPHIC study,...
Abstract Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we interrogate hepatocyte protein secretion in two models of murine NASH to understand how liver-derived factors modulate lipid metabolism insulin sensitivity peripheral tissues. We reveal striking hepatokine remodelling that is associated with resistance maladaptive metabolism,...