Richard N. Bergman
A5030791389- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Genetic Associations and Epidemiology
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Skin and Cellular Biology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Autoimmune Bullous Skin Diseases
- Diet, Metabolism, and Disease
- Cutaneous lymphoproliferative disorders research
- Genetic Mapping and Diversity in Plants and Animals
- Nutrition, Genetics, and Disease
- Hair Growth and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lymphoma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Peroxisome Proliferator-Activated Receptors
- Urticaria and Related Conditions
- Cardiovascular Function and Risk Factors
Cedars-Sinai Medical Center
2015-2024
Rambam Health Care Campus
2014-2024
Tel Aviv Sourasky Medical Center
2024
Deutsches Schiffahrtsmuseum
2024
Rappaport Family Institute for Research in the Medical Sciences
2004-2022
Technion – Israel Institute of Technology
2012-2022
Group Image (Poland)
2022
International Rescue Committee
2022
Prince Sultan University
2022
University of Michigan
1991-2021
Identifying the genetic variants that increase risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) imputed genotypes for an additional >2 million autosomal SNPs. We carried out analysis these SNPs to identify predispose T2D, compared our results two similar studies, 80 1215 1258 NGT controls....
We have evaluated the feasibility of using a mathematical model glucose disappearance to estimate insulin sensitivity. Glucose was injected into conscious dogs at 100, 200, or 300 mg/kg. The measured time course regarded as "input," and falling concentration "output" physiological system storing glucose. Seven models uptake were compared identify representation most capable simulating disappearance. One specific nonlinear superior in that it 1) predicted after injection, 2) had four...
The quantitative contributions of pancreatic responsiveness and insulin sensitivity to glucose tolerance were measured using the "minimal modeling technique" in 18 lean obese subjects (88-206% ideal body wt). individual secretion action by interpreting dynamics plasma during intravenous test terms two mathematical models. One, kinetics model, yields parameters first-phase (phi 1) second-phase 2) responsivity beta-cells glucose. other model parameters, SI. Lean subdivided into good (KG...
To determine the relationship between insulin sensitivity and β-cell function, we quantified index using minimal model in 93 relatively young, apparently healthy human subjects of varying degrees obesity (55 male, 38 female; 18–44 yr age; body mass 19.5–52.2 kg/m2) with fasting glucose levels <6.4 mM. SI was compared measures adiposity function. Although lean individuals showed a wide range SI, were related curvilinear manner (P < 0.0001) so that on average, an increase...
Obesity is a growing problem in the United States and throughout world. It risk factor for many chronic diseases. The BMI has been used to assess body fat almost 200 years. known be of limited accuracy, different males females with similar %body adiposity. Here, we define an alternative parameter, adiposity index (BAI = ((hip circumference)/((height)(1.5))-18)). BAI can reflect adult men women differing ethnicities without numerical correction. We population study, "BetaGene" develop new...
Studies were done to determine whether the minimal model approach and glucose clamp measure equivalent indices of insulin action. Euglycemic clamps (glucose, G: 85 mg/dl) performed at two rates (I) infusion (15 40 mU/min per m2) in 10 subjects (body mass index, BMI, from 21 41 kg/m2). Insulin sensitivity index (SI) varied 0.15 3.15 (mean: 1.87 +/- 0.36 X 10(-2) dl/[min m2] microU/ml), declined linearly with increasing adiposity (versus BMI: r = -0.97; P less than 0.001). SI modeling modified...
Background Reduced insulin sensitivity has been proposed as an important risk factor in the development of atherosclerosis. However, is related to many other cardiovascular factors, including plasma levels, and it unclear whether independent role exists. Large epidemiological studies that measure directly have not conducted. Methods Results The Insulin Resistance Atherosclerosis Study (IRAS) evaluated (S I ) by frequently sampled intravenous glucose tolerance test with analysis minimal model...