A5021476261- Bone fractures and treatments
- Radiation Dose and Imaging
- Neurobiology and Insect Physiology Research
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Ion channel regulation and function
- Advanced X-ray and CT Imaging
- Regulation of Appetite and Obesity
- Healthcare and Venom Research
- Ocular Diseases and Behçet’s Syndrome
- Advanced Radiotherapy Techniques
- Osteomyelitis and Bone Disorders Research
- Musculoskeletal Disorders and Rehabilitation
- Thyroid Cancer Diagnosis and Treatment
- Biochemical effects in animals
- Medical Imaging Techniques and Applications
- Acne and Rosacea Treatments and Effects
- Orthopaedic implants and arthroplasty
- Tryptophan and brain disorders
- Pelvic and Acetabular Injuries
- Diphtheria, Corynebacterium, and Tetanus
- Sarcoidosis and Beryllium Toxicity Research
- Diet and metabolism studies
- Historical Medical Research and Treatments
University of Kragujevac
2012-2022
University of Nis
2010-2022
Beiersdorf (Germany)
2014-2019
Addenbrooke's Hospital
2007-2016
University of Cambridge
2007-2016
Wellcome/MRC Institute of Metabolic Science
2009-2016
Wellcome Trust
2016
Institute of Economic Sciences
2015
University of Oxford
2007
Science Oxford
2007
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body index humans. Here, we show by bioinformatics analysis that shares sequence motifs Fe(II)- 2-oxoglutarate–dependent oxygenases. We find recombinant murine Fto catalyzes 2OG-dependent demethylation of 3-methylthymine single-stranded DNA, concomitant production succinate, formaldehyde, carbon dioxide. Consistent a potential role nucleic acid demethylation, localizes to nucleus transfected cells....
Numerous new genes have recently been identified in genome-wide association studies for type 2 diabetes. Most are highly expressed beta cells and presumably play important roles their function. However, these account only a small proportion of total risk there likely to be additional candidate not detected by current methodology. We therefore investigated islets from the polygenic New Zealand mouse (NZL) model diet-induced cell dysfunction identify novel pathways that may role pathogenesis...
Though obesity is a global epidemic, the physiological mechanisms involved are little understood. Recent advances reveal that susceptibility to can be programmed by maternal and neonatal nutrition. Specifically, low protein diet during pregnancy causes decreased intrauterine growth, rapid postnatal catch-up growth increased risk for diet-induced obesity. Given synthesis of neurotransmitter 5-hydroxytryptamine (5-HT) nutritionally regulated 5-HT trophic factor, we hypothesized influences...
We have previously shown that precursors of odorous components characteristic axillary sweat are hardly detectable or undetectable in individuals carrying the 538G > A SNP ABCC11 transporter gene. However, it is unclear, whether directly involved transport these compounds. To approach this question, peptide-conjugated potential 3-methyl-3-sulfanylhexanol (3M3SH), a key determinant malodour, was measured using membrane vesicles Sf9 insect cells overexpressing human ABCC11. Whilst no...
This study aimed to assess sunscreen application habits and relative body coverage after single whole application.Fifty-two healthy volunteers were asked use the test product once, following their usual routine. Standardized UV photographs, which evaluated by Image Analysis, conducted before immediately evaluate coverage. In addition these procedures, completed an online self-assessment questionnaire usage habits.After application, front side showed significantly less non-covered skin...
Interventional radiology and cardiology are widespread employed techniques for diagnosis treatment of several pathologies because they avoid the majority side-effects associated with surgical treatments, but known to increase radiation exposure patient operators. In recent years many studies treated operators performing cardiological procedures. The aim this work is study condition medical staff in some selected interventional Monte Carlo simulations have been anthropomorphic mathematical...
Oxidative stress and the production of reactive oxygen species are known to play a major role in neuronal cell damage, but exact mechanisms responsible for injury death remain uncertain. In present study, we examined effects oxidative on spontaneous spike activity depolarizing outward potassium current by exposing Retzius neurons leech cumene hydroperoxide (CHP) hydrogen peroxide (H2O2), oxidants commonly used examine mediating death. We observed that relatively low concentrations CHP (0.25,...
Aging is an extremely complex, multifactorial process that characterized by a gradual and continuous loss of physiological functions responses, particularly marked in the brain. A common hallmark aging age-related diseases increase oxidative stress failure antioxidant defense systems. Current knowledge indicates level glutathione progressively declines during aging. Because nerve cells are longest-living exhibit high consumption rate oxygen throughout individual?s lifetime, brain may be...
Abstract Background Perioral dermatitis is a clinically distinctive reaction pattern of facial dermatitis, including redness, dryness, burning, pruritus and skin tightness. A gold standard treatment remains unclear. Objectives Our study evaluates the clinical value care cream with transient receptor potential vanilloid type 1 inhibitor 4‐t‐butylcyclohexanol in POD patients over 8 weeks. Methods This open, unblinded 8‐week trial included 48 patients. containing was applied period Standardized...
Background: Alkaline phosphatase is a glycoprotein that catalyzes two kinds of chemical reactions: hydrolysis phosphorus ester breaking P-O bonds and phospho-transfer reactions in which phosphoric group transferred to an acceptor molecule. In the human body, ALP exists multiple molecular forms whose heterogeneity partly due genetic factors posttranslational modifications. The aim was evaluate total activity its isoforms cancer patients with bone liver metastasis comparison healthy controls....
Monte Carlo simulations were performed to evaluate dose for possible treatment of cancers by boron neutron capture therapy (BNCT). The computational model male Oak Ridge National Laboratory (ORNL) phantom was used simulate tumours in the lung. Calculations have been means MCNP5/X code. In this simulation, two opposite beams considered, order obtain uniform flux distribution inside obtained results indicate that lung cancer could be treated BNCT under assumptions calculations.
Although obesity is a global epidemic, the physiological mechanisms involved are not well understood.Recent advances reveal that susceptibility to can be programmed by maternal and neonatal nutrition.Specifically, low-protein diet during pregnancy causes decreased intrauterine growth, rapid postnatal catch-up growth an increased risk for diet-induced obesity.Given synthesis of neurotransmitter 5-hydroxytryptamine (5-HT) nutritionally regulated 5-HT trophic factor, we hypothesised influences...
The effects of Mg2+ on Ni(2+)-induced epileptiform bursting activity and input membrane resistance during this leech Retzius neurons were examined using intracellular recordings. To induce activity, 3 mmol/l NiCl2 was added into superfusing Ringer (Ri) saline. test for dose-dependence the induced MgCl2 in concentrations from 1 to 20 Ni(2+)-containing Ri Input (IMR) measured standard Ri, Ni2+ Mg2+Ni2+ Superfusion with characterized by generation paroxysmal depolarization shifts (PDSs)....