A5074980595- Pain Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects and Toxicity Studies
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Treatment of Major Depression
- Eicosanoids and Hypertension Pharmacology
- Antibiotics Pharmacokinetics and Efficacy
- Schizophrenia research and treatment
- Liver Disease Diagnosis and Treatment
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Renal Transplantation Outcomes and Treatments
- Adipose Tissue and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Pain Management and Opioid Use
- Acute Kidney Injury Research
University of Belgrade
2013-2023
University of Belgrade – Faculty of Medicine
2013-2022
Institut za Reumatologiju
2003-2019
Institute of Pharmacology
1987-2018
Institute of Public Health of Serbia
2018
Centar za Promociju Nauke
2011-2018
Military Medical Academy
1995-2018
University of Defence
2018
Manchester Metropolitan University
2016
Box (United States)
2013
Background— The CHA 2 DS -VASc (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke/transient ischemic attack [TIA], Vascular disease, 65–74 and Sex category [female gender]) schema recently has been introduced to complement the CHADS >75 stroke or TIA) score improve identification of atrial fibrillation (AF) patients at “truly low risk” for thromboembolism. We tested predictive ability -VASc, , van Walraven risk stratification schemes in a cohort...
Objectives The aim of the study was to determine rate Potentially Inappropriate Medicines (PIM) and Potential Prescription Omissions (PPO) according Screening Tool Older Person's potentially inappropriate Prescriptions/Screening Alert doctors Right Treatment (STOPP/START) criteria. Study Design A cross-sectional survey in community pharmacy. Method prospective performed, during March-May 2012, five pharmacies. Patients aged ≥65 years, who collected one or more prescribed medications, were...
Abstract Gentamicin, belonging to the aminoglycosides, possesses greatest nephrotoxic effect of all other antibiotics from this group. On hand, pioglitazone, which represents peroxisome proliferator-activated receptor γ (PPARγ) agonist recently showed antiinflamatory, antioxidative effects, amelioration endothelial dysfunction etc. Therefore, goal our study was investigate effects pioglitazone on kidney injury in an experimental model gentamicin-induced nephrotoxicity rats. These were...
In Brief BACKGROUND: There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models neuropathic pain as well inflammatory somatic pain. Data are lacking on potential these drugs against visceral this study, we examined compared writhing test a model mouse. addition, influence anticonvulsants motor performance was to compare tolerability when used acute METHODS: The were acetic acid mice. side effect propensity using...
What is known and Objective: Lamotrigine metabolism may be substantially altered with concomitant administration of valproic acid and/or carbamazepine. Such alterations require the adjustment lamotrigine dose to ensure optimal treatment efficacy safety. Methods: The extent interactions was investigated dependent on age, gender, weight carbamazepine in 65 patients epilepsy. plasma steady-state oral clearance (CLss/F) area under curve (AUCss) were calculated from drug, average concentration...
Background Acute kidney injury (AKI) still remains an unresolved problem in pharmacotherapy and renal inflammation is a major factor its development. Chloroquine, well-known antimalarial drug, posses pleitropic effects as well: antiinflammatory, anticoagulant vascular actions. The of chloroquine on function may involve significant increase urine flow rate, glomerular filtration rate sodium excretion, well stimulation nitric oxide synthase. However, role experimental models I/R unknown. We...
Magnesium and MK-801 (dizocilpine), antagonists of N-methyl-d-aspartate receptors, are involved in the processing pain.This study determines whether magnesium sulfate (MS) affects visceral inflammatory pain a possible mechanism action.Analgesic activity was assessed using acetic acid-induced writhing test rats. MS (1-45 mg/kg) or (0.005-0.03 administrated subcutaneously (s.c.). To assess mechanisms action, we examined effects l-NAME (10 mg/kg, intraperitoneal), methylene blue (0.5 s.c.),...
The antinociceptive effects of carbamazepine and oxcarbazepine, the influence caffeine, were examined in a paw pressure test rats. Carbamazepine (10-40 mg/kg; intraperitoneal, i.p.) oxcarbazepine (40-160 caused significant dose-dependent reduction inflammatory hyperalgesia induced by concanavalin A (Con A), intraplantarly (i.p1.). comparable pattern effect was observed; only difference is their potency, that about three times more potent than oxcarbazepine. Caffeine (5-20mg/kg; i.p.),...