A5059086798- Pain Mechanisms and Treatments
- Treatment of Major Depression
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Pharmacological Receptor Mechanisms and Effects
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Dialysis and Renal Disease Management
- Pharmaceutical studies and practices
- Magnesium in Health and Disease
- Antibiotics Pharmacokinetics and Efficacy
- Helicobacter pylori-related gastroenterology studies
- Cardiac Ischemia and Reperfusion
- Neuropeptides and Animal Physiology
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Veterinary medicine and infectious diseases
- Lipid Membrane Structure and Behavior
- Veterinary Pharmacology and Anesthesia
- Bipolar Disorder and Treatment
- Ethics in medical practice
University of Belgrade
2015-2024
Institut za Reumatologiju
2022-2024
University of Manchester
2022
Center for Health, Exercise and Sport Sciences
2011
Centar za Promociju Nauke
2011
Abstract Gentamicin, belonging to the aminoglycosides, possesses greatest nephrotoxic effect of all other antibiotics from this group. On hand, pioglitazone, which represents peroxisome proliferator-activated receptor γ (PPARγ) agonist recently showed antiinflamatory, antioxidative effects, amelioration endothelial dysfunction etc. Therefore, goal our study was investigate effects pioglitazone on kidney injury in an experimental model gentamicin-induced nephrotoxicity rats. These were...
This study aimed to evaluate, in vitro, the antioxidative potential of fruit wines produced from berry fruits (i.e., black chokeberry, blueberry, blackberry, and raspberry), cherry, apple by different technological processes. For this purpose, activities antioxidant enzymes (catalase, glutathione peroxidase (GPx), superoxide dismutase (SOD)) malondialdehyde (MDA) content as a marker membrane damage were determined wine-treated synaptosomes with hydrogen peroxide-induced oxidative stress. All...
Background Acute kidney injury (AKI) still remains an unresolved problem in pharmacotherapy and renal inflammation is a major factor its development. Chloroquine, well-known antimalarial drug, posses pleitropic effects as well: antiinflammatory, anticoagulant vascular actions. The of chloroquine on function may involve significant increase urine flow rate, glomerular filtration rate sodium excretion, well stimulation nitric oxide synthase. However, role experimental models I/R unknown. We...
(1) Background: Surgical treatment of laryngeal carcinoma includes different types laryngectomies with neck dissection. tissue damage triggers an inflammatory response, leading to the release pro-inflammatory molecules. This increases reactive oxygen species production and decreases antioxidant defense mechanisms, postoperative oxidative stress. The aim this study was assess correlation between stress (malondialdehyde, MDA; glutathione peroxidase, GPX; superoxide dismutase, SOD) inflammation...
The aim of this study was to examine how ibuprofen and paracetamol prevent pain after cold-steel extracapsular tonsillectomy in children. Also, we examined the relation between age, gender, nausea, postoperative bleeding, antibiotic use, type diet, intensity administered analgesic. A prospective conducted on 147 children (95 males 52 females, aged 7-17 years) who underwent Clinical-Hospital Center “Dragiša Mišović” from January 1 June 30, 2016. degree measured using a visual analog scale...
Background/Aim. Rare diseases are chronic, degenerative and may lead to permanent disability. We aimed assess knowledge attitudes of the 3rd 6th year medical students towards treatment rare in Serbia. Methods. In this cross-sectional study, two samples were questioned for a survey: 350/446 (78.48%) year, 242/517 (46.81%) year. Results. Sixth estimated that they more informed on issue analyzed than (median value 4 3, interquartile range 3-5, 1-4, respectively; p < 0.05). However,...
Mast cell degranulation impacts the development of pain and inflammation during tissue injury. We investigated antinociceptive effect a combination cromoglycate magnesium in orofacial model histological profile pain. In male Wistar rats, formalin (1.5%, 100 µL) was injected subcutaneously into right upper lip rats after and/or magnesium. Pain measured as total time spent on pain-related behavior. Toluidine blue staining used to visualize mast cells under light microscope. test, phase 1,...
Background/Objectives: Besides a multitude of consequences patients on chronic renal replacement therapy have, anemia is one the most prominent factors making significant number dependent erythropoiesis-stimulating agent (ESA) therapy. The aim this study was to examine relationship between levels broad spectrum thrombo-inflammatory and oxidative stress-related biomarkers presence level ESA hyporesponsiveness in undergoing regular hemodialysis. Methods: This cross-sectional included 96...
Magnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate anti-edematous effect magnesium sulfate (MS) in different protocols use and possible mechanism its action.In a rat model carrageenan-induced paw inflammation, activity MS was assessed with plethysmometer. The effects nonselective inhibitor (L-NAME), selective neuronal (L-NPA) inducible (SMT) nitric oxide synthase on were evaluated.MS administered systemically before or after inflammation reduced...
Helicobacter pylori eradication is characterized by decreasing successful rates. Although treatment failure primarily associated with resistance to antibiotics, other unknown factors may influence the outcome. This study aimed assess presence of antibiotics genes in H. and Candida spp., which are proposed be endosymbiotic hosts pylori, gastric biopsies pylori-positive patients while simultaneously assessing their relationship. The detection identification yeasts mutations specific for...
Ketamine as an old - new drug has variety of clinical implications. In the last 30 years, ketamine become popular for acute use in humans. at standard doses is principally utilized induction and maintenance surgical procedures. Beside its anesthesia analgesia, recently studies had shown that find place treatment asthma, epilepsy, depression, bipolar affective disorders, alcohol heroin addiction. Its mechanism action complex, but it mostly acts a noncompetitive antagonist N-methyl-D-aspartate...
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model inflammatory pain rats the combination might be more effective than alone. Antinociceptive activity was assessed formalin test male Wistar (200-250 g). Animals were injected with 100 μL 2.5% to plantar surface right hind paw. Data recorded as total time spent pain-related behavior after injection or vehicle (0.9% NaCl). Ketamine sulfate given separately reduced...
The wider application of gentamicin is limited by potential adverse effects (nephrotoxicity and ototoxicity). goal our study was to investigate the chloroquine on biochemical oxidative stress parameters in gentamicin-induced nephrotoxicity rats. Animals were randomly divided into 1 5 groups. First Sham group (0.9% NaCl) (n = 8); second received while third 8), fourth 8) fifth a dose 0.3, 3 mg/kg, respectively. urea creatinine levels significantly lower treated groups doses 0.3 mg/kg (P <...