A5053853830- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Vasculitis and related conditions
- Diabetes Management and Research
- T-cell and B-cell Immunology
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Dermatology and Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Otitis Media and Relapsing Polychondritis
- Polyomavirus and related diseases
- Single-cell and spatial transcriptomics
- Renal Transplantation Outcomes and Treatments
- Birth, Development, and Health
Immune Tolerance Network
2014-2024
Benaroya Research Institute
2024
University of California, San Francisco
2009-2023
Indianapolis Zoo
2020
Massachusetts General Hospital
2015-2017
Harvard University
2015
Portland VA Medical Center
2011
GlaxoSmithKline (United States)
2008-2010
GlaxoSmithKline (United Kingdom)
2009-2010
University of Ottawa
2010
The 18-month efficacy of a single course rituximab as compared with conventional immunosuppression cyclophosphamide followed by azathioprine in patients severe (organ-threatening) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is unknown.
Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C), triglycerides.We combined data from 8 studies, comprising up 17 723 participants with information on circulating concentrations. did independent replication in 37 774 populations also population Indian Asian descent....
BACKGROUND. Type 1 diabetes (T1D) results from destruction of pancreatic β cells by autoreactive effector T cells. We hypothesized that the immunomodulatory drug alefacept would result in targeted quantitative and qualitative changes prolonged preservation endogenous insulin secretion remaining patients with newly diagnosed T1D.
Autologous hematopoietic stem cell transplantation (HSCT) is commonly employed for hematologic and non-hematologic malignancies. In clinical trials, HSCT has been evaluated severe autoimmunity as a method to "reset" the immune system produce new, non-autoimmune repertoire. While feasibility of eliminating vast majority mature T cells well established, accurate quantitative determination relationship regenerated baseline repertoire difficult assess. Here, in phase II study poor-prognosis...
Teplizumab treatment of nondiabetic relatives at high risk for T1D induces partially exhausted CD8 + T cells and improves beta cell function.
Objective To discover biomarkers involved in the pathophysiology of antineutrophil cytoplasmic antibody–associated vasculitis (AAV) and to determine whether low‐density granulocytes (LDGs) contribute gene expression signatures AAV. Methods The source clinical data linked biologic specimens was a randomized controlled treatment trial RNA sequencing whole blood from patients with AAV performed during active disease at baseline visit remission 6 months later. Gene compared between who met...
BackgroundEarly introduction of dietary peanut in high-risk infants with severe eczema, egg allergy, or both prevented allergy at 5 years age the Learning Early About Peanut Allergy (LEAP) study. The protective effect persisted after 12 months avoiding peanuts 12-month extension LEAP study (LEAP-On). It is unclear whether this benefit allergen and allergic disease specific.ObjectiveWe sought to assess early on development disease, food sensitization, aeroallergen sensitization.MethodsAsthma,...
BackgroundType 1 diabetes results from autoimmune-mediated destruction of β cells. The tyrosine kinase inhibitor imatinib might affect relevant immunological and metabolic pathways, preclinical studies show that it reverses prevents diabetes. Our aim was to evaluate the safety efficacy in preserving β-cell function patients with recent-onset type diabetes.MethodsWe did a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Patients (<100 days diagnosis), aged 18–45...
Biomarkers of transplant tolerance would enhance the safety and feasibility clinical trials potentially facilitate management patients receiving immunosuppression. To this end, we examined blood from spontaneously tolerant renal recipients enrolled in two interventional using flow cytometry gene expression profiling. Using a previously reported cohort as well newly identified patients, confirmed our previous finding that was associated with increased B cell-associated genes relative to...
The immunological mechanism(s) of action whereby teplizumab preserves C-peptide levels in the progression patients with recent onset type 1 diabetes (T1D) is still not well understood. In present study, we evaluated kinetics T cell modulation peripheral blood following two 14-day courses therapy one year apart T1D participants AbATE clinical trial. Transient rises PD-1+Foxp3+ Treg and potentially anergic (CD57−KLRG1−PD-1+) cells circulating CD4 compartment were paralleled by more profound...
Nonsevere relapses are more common than severe in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but their clinical course and treatment outcomes remain largely unexamined. We undertook this study to analyze the of patients with nonsevere Rituximab ANCA-Associated Vasculitis (RAVE) trial who were treated prednisone according a prespecified protocol.RAVE was randomized, double-blind, placebo-controlled comparing rituximab (RTX) cyclophosphamide (CYC) followed by...
A recent study of autologous hematopoietic stem cell transplantation (AHSCT) for active relapsing-remitting multiple sclerosis (RRMS) showed efficacy in preventing disease worsening. However, the immunologic basis remains poorly defined. Multiple pathology is known to be driven by inflammatory T cells that infiltrate CNS. Therefore, we hypothesized preexisting repertoire intrathecal compartment RRMS participants was ablated and replaced with new clones following AHSCT. repertoires were...