A5003279436- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Genetics and Neurodevelopmental Disorders
- Diabetes Management and Research
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Nuclear Receptors and Signaling
- Cellular transport and secretion
- Advanced Drug Delivery Systems
- Birth, Development, and Health
- Electrochemical sensors and biosensors
- Advancements in Transdermal Drug Delivery
- Histone Deacetylase Inhibitors Research
- Corneal Surgery and Treatments
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Graphene and Nanomaterials Applications
- Alzheimer's disease research and treatments
Institut d'électronique de microélectronique et de nanotechnologie
2019-2025
Centre National de la Recherche Scientifique
2015-2025
Université Polytechnique Hauts-de-France
2019-2025
École Centrale de Lille
2019-2025
Université de Lille
2016-2025
Imperial College London
2016-2020
Inserm
2013-2020
(Epi)génomique fonctionnelle métabolique et des dysfonctions dans le diabète de type 2 et des maladies associées
2012-2020
Institut Supérieur de l'Électronique et du Numérique
2019
Institut Pasteur de Lille
2015-2019
Insulin release from pancreatic beta-cells plays an essential role in blood glucose homeostasis. Several proteins controlling insulin exocytosis have been identified, but the factors determining expression of components secretory machinery remain largely unknown. MicroRNAs are newly discovered small non-coding RNAs acting as repressors gene expression. We found that overexpression mir-9 insulin-secreting cells causes a reduction elicited by or potassium. show acts diminishing transcription...
OBJECTIVE—Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental pancreatic β-cells, resulting in reduced insulin content, defective secretion, apoptosis. We investigated the involvement this phenomenon of microRNAs (miRNAs), a class noncoding RNAs regulating gene expression by sequence-specific inhibition mRNA translation. RESEARCH DESIGN AND METHODS—We analyzed miRNA insulin-secreting cell lines or...
OBJECTIVE Pancreatic β-cells exposed to proinflammatory cytokines display alterations in gene expression resulting defective insulin secretion and apoptosis. MicroRNAs are small noncoding RNAs emerging as key regulators of expression. Here, we evaluated the contribution microRNAs cytokine-mediated β-cell cytotoxicity. RESEARCH DESIGN AND METHODS We used global microarray profiling real-time PCR analysis detect changes microRNA islets pre-diabetic NOD mice. assessed involvement affected...
Pregnancy and obesity are frequently associated with diminished insulin sensitivity, which is normally compensated for by an expansion of the functional β cell mass that prevents chronic hyperglycemia development diabetes mellitus. The molecular basis underlying compensatory largely unknown. We found in rodents during pregnancy changes expression several islet microRNAs, including miR-338-3p. In isolated pancreatic islets, we recapitulated decreased miR-338-3p level observed gestation...
The pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) generates pancreatic beta-cells apoptosis mainly through activation of the c-Jun NH(2)-terminal kinase (JNK) pathway. This study was designed to investigate whether long-acting agonist hormone glucagon-like peptide 1 (GLP-1) receptor exendin-4 (ex-4), which mediates protective effects against cytokine-induced beta-cell apoptosis, could interfere with JNK pathway.Isolated human, rat, and mouse islets rat insulin-secreting INS-1E...
Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with type 2 diabetes. Here, we investigated whether endoplasmic reticulum (ER) stress a key player coupling oxidative to beta-cell dysfunction death elicited by human LDL. We found that LDL activates ER as evidenced activation inositol requiring 1α, elevated expression both DDIT3 (also called CHOP) DNAJC3 P58IPK) markers...
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). this study, we hypothesized that the DNA methylome of livers from patients T2D compared individuals normal plasma glucose levels can unveil some mechanism could link to NAFLD. Using and transcriptome analyses obese individuals, found hypomethylation at a CpG site in PDGFA (encoding platelet-derived growth factor α) overexpression are both increased risk,...
Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and the development of novel treatments been disappointing, due poor knowledge how these impact T2D pathophysiology. Here, we aimed measure expression genes located nearby associated signals assess their effect on insulin secretion from pancreatic beta cells. The 104 candidate susceptibility was measured in a...
Reaching the corneal endothelium through topical administration of therapeutic drugs remains a challenge in ophthalmology. Besides, endothelial cells are not able to regenerate, and diseases at this site can lead blindness. Targeting implies efficient penetration three layers, which still difficult for small molecules. Carbon quantum dots (CQDs) have demonstrated great potential ocular nanomedicine. This study focuses on abilities differently charged CQDs their use as permeation enhancers...
Painless and controlled on-demand drug delivery is the ultimate goal for management of various chronic diseases, including diabetes.
Hepatocyte nuclear factor 1α (HNF1α) is an atypical dimeric homeodomain-containing protein that expressed in liver, intestine, stomach, kidney, and pancreas. Mutations the HNF1α gene are associated with autosomal dominant form of non-insulin-dependent diabetes mellitus called maturity-onset young (MODY3). More than 80 different mutations have been identified so far, many which involve highly conserved amino acid residues among vertebrate HNF1α. In present work, we investigated molecular...
Drug loaded hydrogels have proven to be versatile controlled-release systems.
We demonstrate insulin delivery by electrothermal patches engineered <italic>via</italic> standard microfabrication protocols from thin metal-on-polymer laminates.
Expression of concern for ‘Innovative transdermal delivery insulin using gelatin methacrylate-based microneedle patches in mice and mini-pigs’ by Bilal Demir et al. , Nanoscale Horiz. 2022, 7 174–184, https://doi.org/10.1039/D1NH00596K.