A5052529308- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Ultrasound and Hyperthermia Applications
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- 3D Printing in Biomedical Research
- Ultrasound and Cavitation Phenomena
- CAR-T cell therapy research
- Retinal Development and Disorders
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Fluorescence Microscopy Techniques
- Inhalation and Respiratory Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- DNA and Nucleic Acid Chemistry
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
Ghent University
2016-2025
Nanjing Forestry University
2016-2025
Cancer Research Institute Ghent
2017-2024
Ghent University Hospital
2001-2024
Charles University
2023
Pharmaceutical Biotechnology (Czechia)
2021
University of Coimbra
2019
University of Twente
2019
Université Paris Cité
2019
Max Planck Institute for Molecular Genetics
2013
Nonviral gene complexes can enter mammalian cells through different endocytic pathways. For efficient optimization of the carrier it is important to profile its cellular uptake, because this largely determines intracellular processing and subsequent transfection efficiency. Most current information on uptake these gene-delivery vehicles based data following use chemical inhibitors Here, we have performed a detailed characterization four commonly used endocytosis [chlorpromazine, genistein,...
Nanosized hydrogels (nanogels) have attracted considerable attention as multifunctional polymer-based drug delivery systems. Their versatility is demonstrated both in encapsulation and release. Nanogels can be designed to facilitate the of diverse classes bioactive compounds. With optimization their molecular composition, size morphology, nanogels tailor-made sense respond environmental changes order ensure spatial stimuli-controlled release vivo. This manuscript aims highlight recent...
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Ambient particulate matter pollution has posed serious threats to global environment and public health. However, highly efficient filtration of submicron particles, the so-named "secondary pollution" caused by, e.g., bacterial growth in filters use nondegradable filter materials, remains a challenge. In this study, poly(vinyl alcohol) (PVA) konjac glucomannan (KGM)-based nanofiber membranes, loaded with ZnO nanoparticles, were prepared through green electrospinning ecofriendly thermal...
Intracellular uptake and degradation of polyelectrolyte capsules is reported in this work. Two types intracellular degradable are described: enzyme-sensitive hydrolysis- sensitive (see figure). The results may be a significant step towards the biomedical application capsules.
Drug delivery with microbubbles and ultrasound is gaining more attention in the drug field due to its noninvasiveness, local applicability, proven safety ultrasonic imaging techniques. In this article, we tried improve cytotoxicity of doxorubicin (DOX)-containing liposomes by preparing DOX-liposome-containing for therapeutic ultrasound. way, DOX release uptake can be restricted ultrasound-treated areas. Compared DOX-liposomes, DOX-loaded killed at least two times melanoma cells after...
In this paper we review the recent contributions of polyelectrolyte microcapsules in biomedical field, comprising vitro and vivodrug delivery as well their applications biosensors.
The in vitro labeling of therapeutic cells with nanoparticles (NPs) is becoming more and common, but concerns about the possible effects NPs on cultured are also increasing. In present work, we evaluate poly(methacrylic acid)-coated 4 nm diameter Au a variety sensitive therapeutically interesting cell types (C17.2 neural progenitor cells, human umbilical vein endothelial PC12 rat pheochromocytoma cells) using multiparametric approach. Using various NP concentrations incubation times,...
The use of DNA and viral vector-based vaccines for the induction cellular immune responses is increasingly gaining interest. However, concerns have been raised regarding safety these immunization strategies. Due to lack their genome integration, mRNA-based emerged as a promising alternative. In this study, we evaluated potency antigen-encoding mRNA complexed with cationic lipid 1,2-dioleoyl-3trimethylammonium-propane/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOTAP/DOPE ) novel...