A5088946428- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Functional Brain Connectivity Studies
- Ultrasound Imaging and Elastography
- Histone Deacetylase Inhibitors Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Dementia and Cognitive Impairment Research
- Chronic Myeloid Leukemia Treatments
- Neural dynamics and brain function
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Protein Degradation and Inhibitors
- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Vestibular and auditory disorders
- Angiogenesis and VEGF in Cancer
- Hearing Loss and Rehabilitation
- Thermoregulation and physiological responses
- Advanced MRI Techniques and Applications
- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
Peking University
2023-2024
Ludwig-Maximilians-Universität München
2021-2024
Southeast University
2024
Zhongda Hospital Southeast University
2017-2024
Zhengzhou University
2021-2023
LMU Klinikum
2022-2023
Politecnico di Milano
2023
First Affiliated Hospital of Zhengzhou University
2023
Erasmus University Rotterdam
2012-2021
Erasmus MC
2011-2021
Abstract Purpose: The safety and efficacy of ibrutinib, a once-daily Bruton's tyrosine kinase (BTK) inhibitor, in chronic lymphocytic leukemia/small lymphoma (CLL/SLL) was demonstrated this phase Ib/II study. Extended follow-up up to 8 years is described, representing the longest for single-agent or any BTK date. Patients Methods: Phase PCYC-1102 (NCT01105247) extension study PCYC-1103 (NCT01109069) included patients receiving ibrutinib first-line relapsed/refractory CLL/SLL. Results:...
Abstract Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer’s disease, but the functional brain mechanisms that support remain elusive. Given previous findings normal ageing, we tested hypothesis higher segregation brain’s connectome into distinct networks represents a mechanism underlying disease. Using resting-state MRI, assessed both MRI global system segregation, i.e. balance between-network to within-network connectivity, and alternate index...
Abstract Purpose: Additional targeted therapeutics are needed for the treatment of lymphoma. Abexinostat is an oral pan-histone deacetylase inhibitor (HDACi) displaying potent activity in preclinical models. We conducted a multicenter phase I/II study (N = 55) with single-agent abexinostat relapsed/refractory Experimental Design: In I, 25 heavily pretreated patients any lymphoma subtype received ranging from 30 to 60 mg/m2 twice daily 5 days/week 3 weeks or 7 given every other week. Phase II...
Histone deacetylase inhibitors are members of a class epigenetic drugs that have proven activity in T-cell malignancies, but little is known about their efficacy B-cell lymphomas. Abexinostat an orally available hydroxamate-containing histone inhibitor differs from approved inhibitors; its unique pharmacokinetic profile and oral dosing schedule, twice daily four hours apart, allows for continuous exposure at concentrations required to efficiently kill tumor cells. In this phase II study,...
Acoustically sensitive emulsions are a promising tool for medical applications such as localized drug delivery. The physical mechanisms underlying the ultrasound-triggered nucleation and subsequent vaporization of these phase-change largely unexplored. Here, acoustic individual micron-sized perfluoropentane (PFP) droplets is studied at nanoseconds timescale. Highly diluted PFP-in-water oil-in-PFP-in-water droplets, ranging from 3.5 to 11 μm in radius, were prepared growth vapor bubbles was...
The Brandaris 128 ultra-high-speed imaging facility has been updated over the last 10 years through modifications made to camera's hardware and software. At its introduction camera was able record 6 sequences of images (500 × 292 pixels) at a maximum frame rate 25 Mfps. segmented mode revised allow for subdivision image sensors into arbitrary segments (1-128) with an inter-segment time 17 μs. Furthermore, region interest can be selected increase number recordings within single run from up...
The high efficiency with which gas microbubbles can scatter ultrasound compared the surrounding blood pool or tissues has led to their widespread employment as contrast agents in imaging. In recent years, applications have been extended include super-resolution imaging and stimulation of localized bio-effects for therapy. growing exploitation particular these developments amplified need characterize fully understand microbubble behavior. aim doing so is more exploit utility both diagnostic...
To assess the respective diagnostic value of Sonazoid™ and SonoVue® for characterizing FLLs as benign or malignant corresponding safety.
Ultrasound contrast agents as drug-delivery systems are an emerging field. Recently, we reported that targeted microbubbles able to sonoporate endothelial cells in vitro. In this study, investigated whether can also induce sonoporation of vivo, thereby making it possible combine molecular imaging and drug delivery. Live chicken embryos were chosen the vivo model. α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">v</sub> ß...
Abstract Ultrasound-driven microbubbles are attractive for a variety of applications in medicine, including real-time organ perfusion imaging and targeted molecular imaging. In ultrasound-mediated drug delivery, bubbles decorated with functional payload become convenient transport vehicles offer highly localized release. How to efficiently release these nanomedicines the target site remains unclear owing microscopic length scales nanoseconds timescales process. Here, we show theoretically...
An extended aperture has the potential to greatly improve ultrasound imaging performance. This work extends effective size by coherently compounding received radio frequency data from multiple transducers. A framework is developed in which an system consisting of $N$ synchronized matrix arrays, each with partly shared field view, take turns transmit plane waves. Only one individual transducer transmits at time while all transducers simultaneously receive. The subwavelength localization...