Eric McDade
A5068373508- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Genomics and Rare Diseases
- Tryptophan and brain disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Imaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Down syndrome and intellectual disability research
- Statistical Methods and Inference
- Frailty in Older Adults
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Ginkgo biloba and Cashew Applications
- Cardiovascular Health and Disease Prevention
- Cancer-related cognitive impairment studies
Washington University in St. Louis
2016-2025
Prevent Alzheimer’s Disease 2020
2016-2024
University of Pittsburgh
2011-2023
University of Missouri–St. Louis
2023
Alzheimer’s Disease Neuroimaging Initiative
2015-2023
Hope Center for Neurological Disorders
2022-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Clinical Trial Investigators
2023
The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the develops over many years. Autosomal dominant has a predictable age at onset provides an opportunity to determine sequence changes that culminate symptomatic disease.
White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression Alzheimer's disease (AD). These observations typically interpreted as evidence vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features AD. We examined the severity distribution in...
Abstract The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 single 2012 2018 to create recommendations for diagnosis characterization of disease (AD). present document updates research framework response several recent developments. Defining diseases biologically, rather than based syndromic presentation, has long been standard many areas medicine (e.g., oncology), is becoming a unifying concept common all neurodegenerative diseases,...
To investigate age-related default mode network (DMN) connectivity in a large cognitively normal elderly cohort and patients with Alzheimer disease (AD) compared age-, gender-, education-matched controls.We analyzed task-free-fMRI data both independent component analysis seed-based to identify anterior posterior DMNs. We investigated changes sample of 341 subjects. then 28 AD 56 noncarriers the APOE ε4 allele matched for age, education, gender.The DMN shows age-associated increases decreases...
Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering these biomarkers prior to dementia remains untested. In a cohort with disease mutations, we performed an integrated whole-brain analysis three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose structural MRI. We found that most gray-matter structures plaques later have hypometabolism followed by atrophy. Critically,...
<h3>Objective</h3> To assess the onset, sequence, and rate of progression comprehensive biomarker clinical measures across spectrum Alzheimer disease (AD) using Dominantly Inherited Network (DIAN) study compare these to cross-sectional estimates. <h3>Methods</h3> We conducted longitudinal clinical, cognitive, CSF, neuroimaging assessments (mean 2.7 [±1.1] visits) in 217 DIAN participants. Linear mixed effects models were used changes each measure relative individuals9 estimated years symptom...
Abstract Introduction The Dominantly Inherited Alzheimer Network Trials Unit (DIAN‐TU) trial is an adaptive platform testing multiple drugs to slow or prevent the progression of Alzheimer's disease in autosomal dominant (ADAD) families. With completion enrollment first two drug arms, DIAN‐TU now plans add new platform, designated as Next Generation (NexGen) prevention trial. Methods In collaboration with ADAD families, philanthropic organizations, academic leaders, Pharma Consortium,...
Abstract Background Lecanemab, a humanized IgG1 monoclonal antibody that targets soluble aggregated Aβ species (protofibrils), has demonstrated robust brain fibrillar amyloid reduction and slowing of clinical decline in early AD. The objective this analysis is to report results from study 201 blinded period (core), the open-label extension (OLE), gap (between core OLE) supporting effectiveness lecanemab. Methods lecanemab was double-blind, randomized, placebo-controlled 856 patients...
Macrophages are important players in the maintenance of tissue homeostasis1. Perivascular and leptomeningeal macrophages reside near central nervous system (CNS) parenchyma2, their role CNS physiology has not been sufficiently well studied. Given continuous interaction with cerebrospinal fluid (CSF) strategic positioning, we refer to these cells collectively as parenchymal border (PBMs). Here demonstrate that PBMs regulate CSF flow dynamics. We identify a subpopulation express high levels...
Tauopathy is a hallmark pathology of Alzheimer's disease with strong relationship cognitive impairment. As such, understanding tau may be key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid assays, but these do not provide information about where in the brain. The introduction PET ligands that bind paired helical filaments provides ability measure amount and distribution pathology. heritability age dementia onset tied specific mutations found...
Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against pathology, its effect on tau pathology and potential beneficial role people with disease still unclear. Our aim was study associations between dynamics soluble TREM2, as a biomarker signalling, amyloid β (Aβ) deposition, tau-related neuroimaging markers, cognitive decline,...
Abstract Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation amyloid-β (Aβ) peptide into plaques and microtubule protein tau neurofibrillary tangles (NFTs)—are hallmarks disease. However, other brain processes are thought to be key mediators Aβ plaque NFT pathology. How these additional pathologies evolve over course is currently unknown. Here we show that proteomic measurements in autosomal dominant AD...
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. However, cell-specific effect these is not fully understood. Here, we perform single-nucleus RNA-sequencing (snRNA-seq) on nearly 300,000 nuclei from parietal cortex AD autosomal dominant (APP PSEN1) risk-modifying variant (APOE, TREM2 MS4A) carriers. Within individual cell types, capture commonly dysregulated across groups. specific...
A clock relating amyloid positron emission tomography (PET) to time was used estimate the timing of biomarker changes in sporadic Alzheimer disease (AD).
Objective To examine default mode and salience network functional connectivity as a function of APOE ε4 status in group cognitively normal age-, sex-, education-matched older adults. Design Case-control study. Subjects Fifty-six carriers 56 sex- noncarriers. Main Outcome Measure Alterations in-phase compared with noncarriers ranging from 63 to 91 years age. Results A posterior cingulate seed revealed decreased regions the that included left inferior parietal lobe, middle temporal gyrus,...