Lawrence S. Honig
A5003680013- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Epigenetics and DNA Methylation
- Neurological diseases and metabolism
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Health, Environment, Cognitive Aging
- Cholinesterase and Neurodegenerative Diseases
- Telomeres, Telomerase, and Senescence
- Amyotrophic Lateral Sclerosis Research
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Frailty in Older Adults
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Genetics, Aging, and Longevity in Model Organisms
- Nuclear Receptors and Signaling
- Developmental Biology and Gene Regulation
- Memory and Neural Mechanisms
Columbia University
2016-2025
Columbia University Irving Medical Center
2016-2025
NewYork–Presbyterian Hospital
2010-2025
Columbia College
2011-2025
Royal College of Physicians
2010-2025
University of California, San Diego
2023-2024
Pontificia Universidad Católica Madre y Maestra
2024
Institute of Neuroimmunology of the Slovak Academy of Sciences
2024
New York Hospital Queens
2010-2024
University of Miami
1988-2024
Bapineuzumab, a humanized anti–amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease.
Abstract Multifactorial mechanisms underlying late-onset Alzheimer’s disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels relation to LOAD progression. We analyse over 7,700 images tens of plasma cerebrospinal fluid biomarkers the Disease Neuroimaging Initiative (ADNI). Through a...
Alzheimer's disease is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The humanized monoclonal antibody solanezumab was designed to increase the clearance from brain of soluble Aβ, peptides that may lead toxic effects in synapses precede deposition fibrillary amyloid.
The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk.To explore association aggregation with AD.The authors followed 1,138 individuals without dementia at baseline (mean age 76.2) for a mean 5.5 years. presence was related to incident possible probable AD.Four (diabetes, hypertension, heart disease, current smoking) were associated higher AD (p < 0.10) when analyzed individually. increased number (diabetes + hypertension...
<b>Objective: </b> To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). <b>Methods: Baseline brain was performed 139 patients with MCI, broadly defined, 63 healthy controls followed for an average 5 years (range 1 9 years). <b>Results: Hippocampal volumes were each largest controls, intermediate MCI nonconverters, smallest converters AD (37 converted AD). In separate Cox proportional...
Despite its being one of the most commonly observed neurological disorders, neuropathological studies essential tremor (ET) are rare. There have been surprisingly few autopsy and even fewer case-control comparisons. The primary objective was to describe quantify pathological changes in 33 ET 21 control brains. A secondary correlate clinical features. We examined tissue from Essential Tremor Centralized Brain Repository. Eight (24.2%) brains had Lewy bodies brainstem, mainly locus ceruleus....
<b><i>Background:</i></b> Plasma amyloid β-peptide (Aβ) 40 and Aβ42 levels are increased in persons with mutations causing early-onset familial Alzheimer’s disease (AD). were also used to link microsatellite genetic markers a putative AD locus on chromosome 10 observed patients incipient sporadic AD. <b><i>Methods:</i></b> The authors measured plasma Aβ40 using sandwich ELISA after the initial examination of 530 individuals participating an epidemiologic study aging dementia. Participants...
Abstract Although, in principle, gene expression profiling is well suited to isolate pathogenic molecules associated with Alzheimer's disease (AD), techniques such as microarray present unique analytic challenges when applied disorders of the brain. Here, we addressed these by first constructing a spatiotemporal model, predicting priori how molecule underlying AD should behave anatomically and over time. Then, guided generated profiles entorhinal cortex dentate gyrus, harvested from brains...
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) simulate spread, compare these simulations observed patterns measured tau-PET 312 individuals along disease continuum. Up 70% the variance overall spatial pattern can be explained our model. Surprisingly, ESM predicts irrespective whether brain...
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk Alzheimer's dementia, while APOE2 lower it not yet known whether homozygotes have particularly low risk. We generated dementia odds ratios and other findings in more than 5,000 clinically characterized neuropathologically cases controls. APOE2/2 was compared to APOE2/3 3/3, an exceptionally ratio APOE4/4, impact APOE4 gene dose significantly greater confirmed group 24,000 unconfirmed Finding...
Delusions and hallucinations are common in Alzheimer disease (AD) there conflicting reports regarding their ability to predict cognitive decline, functional institutionalization. According all previous literature, they not associated with mortality.To examine whether the presence of delusions or has predictive value for important outcomes AD.A total 456 patients AD at early stages (mean Folstein Mini-Mental State Examination [MMSE] score 21 30 entry) were recruited followed up semiannually...
Abstract Alzheimer’s Disease (AD) is a progressive neurodegenerative disease where biomarkers for based on pathophysiology may be able to provide objective measures diagnosis and staging. Neuroimaging scans acquired from MRI metabolism images obtained by FDG-PET in-vivo measurements of structure function (glucose metabolism) in living brain. It hypothesized that combining multiple different image modalities providing complementary information could help improve early AD. In this paper, we...
To estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging an individual's pathology.