A5039338360- Autoimmune Neurological Disorders and Treatments
- Glioma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Brain Metastases and Treatment
- Genetics and Neurodevelopmental Disorders
- Myasthenia Gravis and Thymoma
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Tuberculosis Research and Epidemiology
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- RNA regulation and disease
- Mycobacterium research and diagnosis
- Neuroblastoma Research and Treatments
- Polyomavirus and related diseases
- Neurological and metabolic disorders
- Cancer-related Molecular Pathways
- Leprosy Research and Treatment
- Cellular transport and secretion
- Meningioma and schwannoma management
- Cancer therapeutics and mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Cancer Research and Treatments
- Neurological Complications and Syndromes
- Epilepsy research and treatment
University of Pennsylvania
2011-2024
Universitat de Barcelona
2004-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2012-2021
California University of Pennsylvania
2014-2021
Ragon Institute of MGH, MIT and Harvard
2020
Universidade de São Paulo
2020
Université de Bordeaux
2020
Memorial Sloan Kettering Cancer Center
1993-2019
Institució Catalana de Recerca i Estudis Avançats
2012-2018
Nihon University
2017-2018
Abstract Objective To report the autoantigens of a new category treatment‐responsive paraneoplastic encephalitis. Methods Analysis clinical features, neuropathological findings, tumors, and serum/cerebrospinal fluid antibodies using rat tissue, neuronal cultures, HEK293 cells expressing subunits N ‐methyl‐ D ‐aspartate receptor (NMDAR). Results Twelve women (14–44 years) developed prominent psychiatric symptoms, amnesia, seizures, frequent dyskinesias, autonomic dysfunction, decreased level...
Paraneoplastic limbic encephalitis (PLE) is a rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. The diagnosis difficult because clinical markers are often lacking, symptoms usually precede the of cancer or mimic other complications. frequency antineuronal antibodies in patients with PLE has not been investigated. We examined neurological causal tumours 50 to determine utility paraneoplastic tests. required...
To report the clinical features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in patients < or = 18 years old.Information was obtained by authors referring physicians. Antibodies were determined immunocytochemistry and enzyme-linked immunosorbent assay (ELISA) using HEK293 cells ectopically expressing NR1.Over an 8-month period, 81 (12 male) with anti-NMDAR identified. Thirty-two (40%) =18 old (youngest 23 months, median 14 years); 6 male. The frequency ovarian teratomas 56%...
We report seven patients, six from a single institution, who developed subacute limbic encephalitis initially considered of uncertain aetiology. Four patients presented with symptoms hippocampal dysfunction (i.e. severe short-term memory loss) and three extensive confusion, seizures suspected psychosis). Brain MRI [18F]fluorodeoxyglucose (FDG)-PET complemented each other but did not overlap in 50% the patients. Combining both tests, all had temporal lobe abnormalities, five additional areas...
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective this trial was to determine maximum tolerated dose (MTD) and HCQ in combination radiation therapy (RT) temozolomide (TMZ) for newly diagnosed glioblastoma (GB). A 3 + phase I design followed by a noncomparative II study conducted GB patients after initial resection. Patients received (200 800 mg oral daily) RT concurrent adjuvant TMZ....
To report the clinical, radiological, and immunological association of demyelinating disorders with anti–Nmethyl- D-aspartate receptor (NMDAR) encephalitis.Clinical radiological analysis was done a cohort 691 patients anti-NMDAR encephalitis. Determination antibodies to NMDAR, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG) performed using brain immunohistochemistry cell-based assays.Twenty-three encephalitis had prominent magnetic resonance imaging (MRI) and/or clinical...
Abstract Purpose: Novel agents are currently combined with radiation and temozolomide (RT + TMZ) in newly diagnosed glioblastoma using overall survival as the primary end point. Results of these phase II studies typically compared III European Organization for Research Treatment Cancer (EORTC) data that resulted RT TMZ becoming standard therapy. Experimental Design: The New Approaches to Brain Tumor Therapy (NABTT) Consortium assigned 365 patients four single-cohort similar eligibility...
To report a novel cell surface autoantigen of encephalitis that is critical regulatory subunit the Kv4.2 potassium channels.Four patients with unclear etiology and antibodies similar pattern neuropil brain immunostaining were selected for characterization. Techniques included immunoprecipitation, mass spectrometry, cell-base experiments several dipeptidyl-peptidase-like protein-6 (DPPX) plasmid constructs, comparative wild-type DPPX-null mice.Immunoprecipitation studies identified DPPX as...
To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA (GABAAR) encephalitis.Clinical study of 26 patients, including 17 new (April 2013-January 2016) 9 previously reported patients. Antibodies to α1, β3, γ2 subunits GABAAR were determined using techniques.Patients' median age was 40.5 years (interquartile range 48.5 [13.75-62.35] years; youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration cognition...
<h3>Objective:</h3> To report 14 patients with immune-mediated relapsing symptoms post–herpes simplex encephalitis (HSE) and to compare the clinical immunologic features of teenage adult group those young children. <h3>Methods:</h3> Prospective observational study diagnosed between June 2013 February 2015. Immunologic techniques have been reported previously. <h3>Results:</h3> Among (8 patients, median age 40 years, range 13–69; 5 male), 3 had an acute symptom presentation suggesting a viral...
To report the main syndrome of dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and antibody effects on DPPX/Kv4.2 potassium channels.A retrospective analysis new patients cases reported since 2013 was performed. IgG subclass antibodies cultured neurons were determined with described techniques.Nine identified (median age 57 years, range 36-69 years). All developed severe prodromal weight loss or diarrhea followed by cognitive...
To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians. Antibodies to IgG subclasses were determined brain immunohistochemistry cell-based assays. The examined rat hippocampal neurons reported techniques.From January 2005 May 2017, (median age 29 years, range...
In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a paraneoplastic disorder. Paraneoplastic or encephalitis occurs more frequently testicular cancer than most other cancers. We sought antineuronal antibodies that might be used in diagnostic test for this syndrome.Immunohistochemical immunoblotting techniques were to detect serum cerebrospinal fluid antibodies. Serologic screening complementary DNA library Northern blotting clone the target antigen...
Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, cerebellum. Preliminary studies suggested existence of other Ma different patterns immune response associated with distinct neurologic symptoms cancers. In this study, our aim was isolate full-length sequence new family members, major autoantigen disorder, extend dinical-immunological analysis 29 patients. Sera from selected patients were used probe brainstem cDNA library entire...