A5028734809- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Infectious Encephalopathies and Encephalitis
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Atomic and Subatomic Physics Research
- Antibiotics Pharmacokinetics and Efficacy
- Fetal and Pediatric Neurological Disorders
- E-Learning and Knowledge Management
- Neurological and metabolic disorders
- Trigeminal Neuralgia and Treatments
- Educational Technology in Learning
- Advertising and Communication Studies
- Pharmaceutical studies and practices
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Sympathectomy and Hyperhidrosis Treatments
- Autoimmune Neurological Disorders and Treatments
- Migraine and Headache Studies
- Economic and Social Development
Hospital Clínico Universitario de Valladolid
2011-2023
Universidad de Valladolid
2021-2023
Summary Objective To analyze the effectiveness and tolerability of perampanel across different seizure types in routine clinical care patients with idiopathic generalized epilepsy ( IGE ). Methods This multicenter, retrospective, 1‐year observational study collected data from patient records at 21 specialist units Spain. All who were aged ≥12 years, prescribed before December 2016, had a confirmed diagnosis included. Results The population comprised 149 (60 juvenile myoclonic epilepsy, 51...
Abstract Objective To assess the effectiveness and tolerability of perampanel (PER) monotherapy in routine clinical practice for treatment focal onset generalized tonic‐clonic seizures (GTCS). Methods This multicenter, retrospective, observational study was conducted patients aged ≥12 years treated with PER as primary or converted to by progressive reduction background antiepileptic drugs. Outcomes included retention, responder, seizure‐free rate after 3, 6, 12 months throughout follow‐up....
To assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) evaluate seizure control PWE during after COVID-19.Retrospective, observational, multicenter study conducted 14 hospitals. Medical records randomly selected followed at neurology outpatient clinics were reviewed. Proportion a positive test for SARS-CoV-2 2020 was calculated. Risk factors associated its morbimortality evaluated.2751 included, mean age 48.8 years (18-99), 72.4% had focal epilepsy, 35%...
Experts agree that there is a need for protocols to guide health professionals on how best manage psychiatric comorbidities in patients with epilepsy (PWE). We aimed develop practical recommendations key issues the management of depression PWE. This was qualitative study conducted four steps: (1) development questionnaire PWE be answered; (2) literature review and, if evidence from guidelines/consensus or systematic reviews available, drafting initial recommendations; (3) nominal group...
Purpose Evaluate real-life experience with eslicarbazepine acetate (ESL) after first monotherapy failure in a large series of patients focal epilepsy. Method Multicentre, retrospective, 1-year, observational study older than 18 years, epilepsy, who had failed antiepileptic drug and received ESL. Data from clinical records were analysed at baseline, 3, 6 12 months to assess effectiveness tolerability. Results Eslicarbazepine was initiated 253 patients. The 1-year retention rate 92.9%, the...
Hemicrania continua (HC) is a unilateral and continuous primary headache with superimposed exacerbations frequently associated autonomic features. Diagnostic criteria of HC, according to II Edition International Classification Headache Disorders require complete response indomethacin. HC probably misdiagnosed more often than other headaches. We aim analyze characteristics series 22 consecutive cases HC. recruited patients from outpatient clinic in tertiary hospital over 3-year period...
Clinical practice studies help guide antiepileptic drug (AED) therapy in patient groups routinely excluded from clinical trials, such as the elderly. The Euro-Esli study investigated effectiveness and safety/tolerability of eslicarbazepine acetate (ESL) when used everyday Europe. A subanalysis data elderly patients (≥ 60 years) included was conducted to assess these aspects ESL use this population. a pooled analysis 14 European studies. Effectiveness parameters responder 50% seizure...
To assess the effectiveness and tolerability of eslicarbazepine acetate (ESL) monotherapy in routine clinical practice for treatment focal-onset seizures.Multicenter, retrospective, observational study conducted patients older than 16 years treated with ESL as first-line or converted to from polytherapy other monotherapy. Outcomes included 1-year retention rate, seizure-free rates after 6 12 months treatment, safety/tolerability issues.A total 256 were (106 150 conversion monotherapy; 56...
<h3>Purpose</h3> Real-life experience with eslicarbazepine acetate (ESL) after first monotherapy failure in a large series of patients partial epilepsy <h3>Method</h3> Multicenter, retrospective, 1 year, observational study. Inclusion criteria: 1) older than 18 years; 2) partial-onset seizures; 3) Failure for any reason (efficacy, tolerability, compliance). Time-points revision were at 3, 6 and 12 months. Main objectives to assess efficacy tolerability. <h3>Results</h3> A total 253...