A5013168824- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Neurological disorders and treatments
- Cardiovascular and Diving-Related Complications
- Neonatal and fetal brain pathology
- Hemoglobinopathies and Related Disorders
- Neurological and metabolic disorders
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Aortic Disease and Treatment Approaches
- Neurological Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Atrial Fibrillation Management and Outcomes
Vall d'Hebron Hospital Universitari
2016-2025
Universitat Autònoma de Barcelona
2016-2025
Vall d'Hebron Institut de Recerca
2010-2024
Hebron University
2022-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Clinical Trial Investigators
2022
Universidad Rey Juan Carlos
2020
The University of Melbourne
2018
Inserm
2018
University Hospital and Clinics
2018
Importance Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type acute seizure influences this risk. Objective To compare epilepsy following different types seizures. Design, Setting, Participants This cohort study analyzed data acquired from 2002 to 2019 9 tertiary referral centers. The derivation included adults cohorts 2 case-control studies neuroimaging-confirmed without...
Few studies have prospectively examined the risk of recurrent stroke associated with patent foramen ovale. We present results Spanish right-to-left shunt (RLSh) multicenter study.Four hundred eighty-six patients cryptogenic stoke were included at 17 participating hospitals. Patients by contrast transcranial Doppler methods baseline. The magnitude RLSh was quantified during Valsalva maneuver. Transthoracic and/or transesophageal echocardiography, computed tomography scan, or magnetic...
Background and Purpose— A progressive decline in the odds of favorable outcome as time to reperfusion increases is well known. However, impact specific workflow intervals not clear. Methods— We studied mechanical thrombectomy group (n=103) prospective, randomized REVASCAT (Randomized Trial Revascularization With Solitaire FR Device Versus Best Medical Therapy Treatment Acute Stroke due Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours Symptom Onset) trial. defined 3...
Collateral damage may occur in epilepsy management during the coronavirus (COVID-19) pandemic. We aimed to establish impact of this pandemic on patients terms patient-reported seizure control and emerging symptoms.This is a cross-sectional study including consecutive assessed by telephone contact an clinic first month confinement. Demographic clinical characteristics were recorded, 19-item questionnaire was systematically completed. Data regarding confinement, economic effects pandemic,...
Objective The purpose of this study was to identify risk factors for acute symptomatic seizures and post‐stroke epilepsy after ischemic stroke evaluate the effects reperfusion treatment. Methods We assessed using logistic or Cox regression in a multicenter study, including adults from 8 European referral centers with neuroimaging‐confirmed stroke. compared between participants without treatment following propensity score matching reduce confounding due selection. Results In overall cohort...
Introduction: In addition to clinical factors, blood-based biomarkers can provide useful information on the risk of developing post-stroke epilepsy (PSE). Our aim was identify serum at stroke onset that could contribute predicting patients higher PSE. Patients and methods: From a previous study in which 895 acute were followed-up, 51 developed We selected 15 with PSE controls without epilepsy. biomarker discovery setting, 5 Olink panels 96 proteins each, used determine protein levels....
Animal models of transient ischemia suggest that oxygen-derived free radicals produced on reperfusion ischemic brain could constitute the main cause injury. We aimed to determine presence and role lipid peroxidation protein oxidation-related molecules after tissue plasminogen activator-induced recanalization in human stroke.A total 160 patients with strokes involving middle cerebral artery treated activator 60 healthy controls were included. Blood samples, transcranial Doppler recordings,...
<b><i>Background:</i></b> Cognitive decline after stroke is more common than recurrence. Stroke doubles the risk of dementia and a major contributor to vascular cognitive impairment dementia. Nonetheless, few pharmacological studies have addressed stroke. We assessed safety long-term administration its possible efficacy citicoline in preventing poststroke patients with first-ever ischemic <b><i>Methods:</i></b> Open-label, randomized, parallel...
The severity of status epilepticus (SE) has an important impact in clinical outcomes. Status Epilepticus Severity Score (STESS) is a score for predicting mortality SE at admission. baseline modified Rankin Scale (mRS) might be prognostic factor assessing the short-tem outcomes SE. Therefore, our aim was to evaluate effectiveness mRS and whether its addition STESS improves prediction mortality.Consecutive patients with aged >16 years were recruited during 3 years. Receiver operating...
The σ-1 receptor (Sig-1R) agonist cutamesine (SA4503) enhanced functional recovery after experimental stroke with a treatment initiation window of 48 hours and chronic for 28 days. We conducted phase 2 clinical trial exploring the safety, tolerability, dose range, effects in patients ischemic stroke.Subjects were randomized between 72 to receive 1 mg/d, 3 or placebo Effects on safety function assessed at baseline, end (day 28), follow-up 56).In 60 patients, both dosages was safe well...
The PERaMpanel pooled analysIs of effecTiveness and tolerability (PERMIT) study was a analysis data from 44 real-world studies 17 countries, in which people with epilepsy (PWE; focal generalized) were treated perampanel (PER). Retention effectiveness assessed after 3, 6, 12 months, at the last visit (last observation carried forward). Effectiveness assessments included 50% responder rate (≥ reduction seizure frequency baseline) freedom (no seizures since least prior visit); PWE status...
Collateral circulation (CC) has been associated with recanalization, infarct volume, and clinical outcome in patients undergoing acute reperfusion therapies. However, its relationship the development to malignant middle cerebral artery infarction (mMCAi) not evaluated. Our aim was determine impact of CC using multiphase computed tomographic angiography (during stroke phase prediction mMCAi.Patients consecutive <4.5 hours who were evaluated for therapies presented an M1-MCA or terminal...
Abstract Objective The pharmacokinetics of brivaracetam ( BRV ), added to its effectiveness observed in animal models status epilepticus SE makes this drug attractive for use emergency situations. Our objective was evaluate the intravenous a multicenter study. Methods A retrospective registry cases treated with created. These patients were evaluated between January and December 2018 at seven hospitals Spain. Demographic variables, characteristics, concomitant drugs, loading doses, response...
Objective Novel treatments are needed to control treatment-resistant status epilepticus (SE). We report a summary of clinical cases where perampanel was used in established SE, refractory SE (RSE), or super-refractory (SRSE). Methods Medical records were retrospectively reviewed for administration at five European hospitals between 2011 and 2015. Results Of 1319 patients identified as experiencing 52 (3.9%) received perampanel. Median latency from onset initiation 10 days. Patients with had...
Abstract Objective Blood biomarkers have not been widely investigated in poststroke epilepsy. In this study, we aimed to describe clinical factors and present during acute stroke analyze their association with the development of epilepsy at long term. Methods A panel 14 blood was evaluated patients ischemic hemorrhagic stroke. Biomarkers were normalized standardized using Z ‐scores. Stroke epilepsy‐related variables also assessed: severity, determined by National Institutes Health Scale...
The occurrence of seizures after aneurysmal subarachnoid hemorrhage (aSAH) is associated with a poorer functional and cognitive prognosis less favorable quality life. It would be value to promptly identify patients at risk epilepsy optimize follow-up protocols design preventive strategies. Our aim was develop predictive score help stratify in aSAH.