A5084565202- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
- Neurological Complications and Syndromes
- Psychosomatic Disorders and Their Treatments
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Neuroscience and Music Perception
- Pain Mechanisms and Treatments
- Vestibular and auditory disorders
- Complementary and Alternative Medicine Studies
- Pain Management and Placebo Effect
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Body Image and Dysmorphia Studies
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Music Therapy and Health
- Traumatic Brain Injury and Neurovascular Disturbances
University of Münster
2016-2025
Krankenhaus Lindenbrunn
2016-2025
Henkel (Germany)
2006-2025
University Hospital Münster
2005-2024
Jessa Hospital
2016-2024
Deutsche Gesellschaft für Muskelkranke
2020-2023
Ospedale Santa Corona
2023
West German Heart and Vascular Center Essen
2023
Stuttgart Observatory
2021
FH Aachen
2021
1. Introduction Chronic pain has been recognized as that persists past normal healing time5 and hence lacks the acute warning function of physiological nociception.35 Usually is regarded chronic when it lasts or recurs for more than 3 to 6 months.29 a frequent condition, affecting an estimated 20% people worldwide6,13,14,18 accounting 15% physician visits.25,28 should receive greater attention global health priority because adequate treatment human right, duty any care system provide it.4,13...
A PCR assay that allows simultaneous detection of glycopeptide resistance genotypes and identification to the species level clinically relevant enterococci (Enterococcus faecium, E. faecalis, gallinarum, casseliflavus) was developed. This based on specific amplification internal fragments genes encoding D-alanine:D-alanine ligases related proteins. The specificity tested 5 well-characterized glycopeptide-resistant strains 15 susceptible enterococcal type strains. Clinical isolates could not...
This paper presents diagnostic criteria for vestibular migraine, jointly formulated by the Committee Classification of Vestibular Disorders Bárány Society and Migraine Subcommittee International Headache (IHS). The classification includes migraine probable migraine. will appear in an appendix third edition (ICHD) as a first step new entities, accordance with usual IHS procedures. Probable may be included later version ICHD, when further evidence has been accumulated. diagnosis is based on...
Background: Migraine is one of the most frequent disabling neurological conditions with a major impact on patients’ quality life. Objectives: To give evidence‐based or expert recommendations for different drug treatment procedures in particular migraine syndromes based literature search and consensus an panel. Methods: All available medical reference systems were screened range clinical studies without aura migraine‐like syndromes. The findings these evaluated according to European...
Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid clearance. To examine the role of mannose receptor (MR) in glycoprotein clearance, we generated mice genetically deficient MR. MR −/− were defective clearing proteins bearing accessible and N -acetylglucosamine residues had elevated levels eight different lysosomal hydrolases. Proteomic analysis control mouse sera showed an additional 4 out 52 identified serum. Each these is up-regulated during...
AimsMigraine with aura and patent foramen ovale (PFO) are associated. The Percutaneous Closure of PFO in Migraine Aura (PRIMA) trial is a multicentre, randomized to investigate the effect percutaneous closure patients refractory medical treatment.
This paper presents diagnostic criteria for vestibular migraine, jointly formulated by the Committee Classification of Vestibular Disorders Bárány Society and Migraine Subcommittee International Headache (IHS). It contains a literature update while original from 2012 were left unchanged. The classification defines migraine probable migraine. was included in appendix third edition (ICHD-3, 2013 2018) as first step new entities, accordance with usual IHS procedures. Probable may be later...
Importance Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type acute seizure influences this risk. Objective To compare epilepsy following different types seizures. Design, Setting, Participants This cohort study analyzed data acquired from 2002 to 2019 9 tertiary referral centers. The derivation included adults cohorts 2 case-control studies neuroimaging-confirmed without...
Acquired VanA- and VanB-type glycopeptide resistance in enterococci is due to synthesis of modified peptidoglycan precursors terminating D-lactate. As opposed VanA-type strains which are resistant both vancomycin teicoplanin, remain teicoplanin susceptible. We have determined the sequence a 7,160-bp DNA fragment associated with Enterococcus faecalis V583 that contains seven open reading frames. The distal part encoded VanH (B), VanB, VanX (B) proteins highly similar putative VanH, VanA,...
The migraine prophylactic effect of 10 mmol magnesium twice-daily has been evaluated in a multicentre, prospective, randomized, double-blind, placebo-controlled study. Patients with two to six attacks per month without aura, and history at least 2 years, were included. A 4-week baseline period medication was followed by 12 weeks treatment or placebo. primary efficacy end-point reduction 50% intensity duration hours the end compared baseline. With calculated total sample size 150 patients, an...
Background: Medication overuse headache is a common condition with population-based prevalence of more than 1–2%. Treatment based on education, withdrawal treatment (detoxification), and prophylactic treatment. It also includes management headache. Aims: This guideline aims to give recommendations for this Materials methods: Evaluation the scientific literature. Results: Abrupt or tapering down overused medication recommended, type therapy probably not relevant outcome patient. However,...
Botulinum toxin A has been suggested to be effective in the prophylactic treatment of migraine. However, only very few randomized, double-blind, placebo-controlled studies are available. We designed such a study with specific focus on different injection sites. Sixty patients migraine according criteria International Headache Society were randomly assigned receive either placebo frontal and neck muscles, or 16 U botulinum muscles total 100 muscles. The observation period was 3 months. In...
Bacillus subtilis and licheniformis are widely used for the large-scale industrial production of proteins. These strains can efficiently secrete proteins into culture medium using general secretion (Sec) pathway. A characteristic feature all secreted is their N-terminal signal peptides, which recognized by machinery. Here, we have studied an industrially important protease, namely, subtilisin BPN' from amyloliquefaciens. One hundred seventy-three peptides originating B. 220 type strain were...
<b>Objective: </b> Medication-overuse headache (MOH) in cluster (CH) patients is incompletely described, perhaps because of the relatively low prevalence CH. <b>Methods: The authors describe a retrospective series 17 (13 men, 4 women) with CH who developed MOH association overuse wide range monotherapies or varying combinations simple analgesics (n = 9), caffeine 1), opioids 10), ergotamine 3), and triptans 14). includes both episodic 7) chronic 10) patients. <b>Results: A specific...