A5101608465- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Ophthalmology and Eye Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Vestibular and auditory disorders
- Biochemical effects in animals
- Psychosomatic Disorders and Their Treatments
- Neurological Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Sleep and Wakefulness Research
- Cerebral Venous Sinus Thrombosis
- Metal complexes synthesis and properties
- Metabolism and Genetic Disorders
- Stress Responses and Cortisol
University of Zurich
2009-2024
Stiftung für Forschung in Spätantike und Mittelalter HR. Sennhauser
2011-2024
University Hospital of Zurich
2008-2024
Saint Francis Hospital & Medical Center
2014-2022
Medical University of Vienna
2011-2021
Semmelweis University
2003-2020
Saint Francis University
2014-2020
Hartford Financial Services (United States)
2020
Trinity Health
2019
St. Francis Hospital
2019
Background: Migraine is one of the most frequent disabling neurological conditions with a major impact on patients’ quality life. Objectives: To give evidence‐based or expert recommendations for different drug treatment procedures in particular migraine syndromes based literature search and consensus an panel. Methods: All available medical reference systems were screened range clinical studies without aura migraine‐like syndromes. The findings these evaluated according to European...
Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 × 100 mg/day) and placebo 42 patients a double-blind, randomized, placebo-controlled trial. was superior for attack-frequency, headache-days days-with-nausea the third treatment month well tolerated; 50%-responder-rate attack frequency 14.4% 47.6% (number-needed-to-treat: 3). efficacious tolerated.
Patients with chronic daily headache and overuse of analgesics, triptans, or other acute compounds, are considered to suffer from medication-overuse (MOH). This implies that medication is the cause chronification. It remains a key question why only two-thirds patients migraine-like pain improve after detoxification, whereas remainder continue have headache. In present longitudinal MRI study, we used voxel-based morphometry investigate gray matter changes related withdrawal in group humans...
In collaboration with some of the leading headache centres in Germany, Switzerland and Austria, we have established new guidelines for treatment migraine attacks prevention migraine. A thorough literature research last 10 years has been basis current recommendations. At beginning, present therapeutic novelties, followed by a summary all After an introduction, cover topics like drug therapy practical experience, non-effective medication, prevention, interventional methods, non-medicational...
Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive some function/oxidative markers have yet examined. To this end, alpha-lipoic acid (ALA), total thiols, plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c lactate were determined serum 32 higher frequency episodic migraineurs (5-14 migraine days/ months, 19 with aura, 28 females)...
The brain and its health are essential for our (physical mental, social, spiritual) wellbeing, being able to realize potential as individuals, also a fair, well-functioning, productive society. However, today the world is facing healthcare crisis related very high (and increasing) burden of disorders. As response this crisis, “Swiss Brain Health Plan” (SBHP) was conceptualized in context other initiatives launched value, promote, protect over entire life course. In first section position...
Objective.– To investigate the influence of different pharmacological treatments on intensity dependence auditory evoked cortical potentials in migraineurs. Background.– Between attacks, patients with migraine show abnormalities information processing and decreased brain mitochondrial energy reserve. Both are most probably relevant for pathogenesis, they could be differentially modified by prophylactic drug therapy. Design. –The is, average, increased migraine. We have studied this 26 before...
Three cannabis constituents, cannabidiol (1), Δ8-tetrahydrocannabinol (3), and cannabinol (5), were oxidized to their respective para-quinones 2, 4, 6. In the 1960s, product 4 had been assigned a para-quinone structure, which was later modified an ortho-quinone. To distinguish between two possible quinone structures, detailed NMR investigation undertaken. The original structure confirmed. X-ray crystallography elucidated structures of crystalline 2 All three compounds displayed...
Background.—Impaired mitochondrial phosphorylation potential may play a role in migraine pathogenesis. Metabolic enhancers, such as riboflavin or coenzyme Q, are effective prophylaxis and quasi‐devoid of adverse effects. Thioctic acid (‐lipoïc acid) is another substance known to enhance energy metabolism mitochondria be beneficial diabetic neuropathy. Objective.—After an open pilot study suggesting its therapeutic antimigraine potentials, we embarked therefore randomized controlled trial...
Dogs were anesthetized with α-D (+)-glucochloralose. After bleeding to a mean arterial pressure of 55 mm Hg, blood flow in subcutaneous adipose tissue decreased from 6 ± 0.9 (mean SE) 0.6 0.21 ml/min/100 g (P < 0.001), and remained at that low level during 35 Hg for an additional 90-minute period. In five out nine experiments the ceased completely. Sixty minutes after reinfusion, was significantly lower than control, two there no reinfusion. animals previously treated phenoxybenzamine (5...
The nuclear enzyme poly(ADP-ribose) polymerase (PARP) is activated by oxidative stress and plays a significant role in postischemic brain injury. We assessed the contribution of PARP activation to blood–brain barrier (BBB) disruption edema formation after ischemia–reperfusion. In male Wistar rats, global cerebral ischemia was achieved occluding carotid arteries lowering arterial blood pressure for 20 mins. animals were treated with saline or inhibitor N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-...
Introduction: Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. Methods: We retrospectively analysed efficacy safety 121 GON injections in 60 patients episodic or chronic headache over period 4 years. Results: Almost 80% infiltrations were at least partially effective (reduction attack frequency, duration severity) 45% resulted complete response (no further attacks). The effect was maintained 3.5 weeks on...
The role of nitric oxide (NO) in the mediation cerebrovascular CO 2 responsiveness was studied 10 distinct brain and spinal cord regions anesthetized, ventilated, temperature-controlled, normoxic cat. Regional CBF measured with 15-μm radiolabeled microspheres hypocapnic, normocapnic, hypercapnic conditions. each region determined from equation best-fit regression lines to obtained flow values. effect altered endothelial and/or neuronal NO synthesis on following either selective blockade...
Objective The aim of this study was to measure the interictal burden (IIB) associated with cluster headache (CH). Background CH is characterized by an alternation excruciatingly painful attacks and pain‐free periods. Absence pain does not necessarily imply absence symptoms, though. Some may persist or improve more slowly than pain; others arise in between attacks. Methods Participants filled out online survey based on EUROLIGHT questionnaire. Inclusion criteria were a reported diagnosis...
Migraine pathophysiology is complex and probably involves cortical subcortical alterations. Structural functional brain imaging studies indicate alterations in the higher order visual cortex patients with migraine. Arterial spin labeling magnetic resonance (ASL-MRI) a non-invasive method for assessing changes cerebral blood flow (CBF) vivo.To examine if interictal CBF differs between episodic migraine (EM) or without aura healthy controls (HC).We assessed using 2D pseudo-continuous ASL-MRI...