A5068017029- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Neurological and metabolic disorders
- Neonatal and fetal brain pathology
- Neurological Complications and Syndromes
- Cardiac electrophysiology and arrhythmias
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic Neurodegenerative Diseases
- Hemoglobinopathies and Related Disorders
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Prion Diseases and Protein Misfolding
- Intracranial Aneurysms: Treatment and Complications
- Migraine and Headache Studies
- Mitochondrial Function and Pathology
- CNS Lymphoma Diagnosis and Treatment
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Syncope and Autonomic Disorders
Vall d'Hebron Institut de Recerca
2013-2024
Vall d'Hebron Hospital Universitari
2008-2023
Universitat Autònoma de Barcelona
2011-2022
The severity of status epilepticus (SE) has an important impact in clinical outcomes. Status Epilepticus Severity Score (STESS) is a score for predicting mortality SE at admission. baseline modified Rankin Scale (mRS) might be prognostic factor assessing the short-tem outcomes SE. Therefore, our aim was to evaluate effectiveness mRS and whether its addition STESS improves prediction mortality.Consecutive patients with aged >16 years were recruited during 3 years. Receiver operating...
Summary Ictal‐MRI studies including diffusion‐weighted imaging (DWI), perfusion‐weighted (PWI), and MR‐angiography (MRA) in patients with aphasic status epilepticus (ASE) are lacking. In this report, we aim to describe the consequences of ASE on DWIs its impact cerebral circulation. We retrospectively studied eight confirmed by ictal‐EEG, who underwent ictal‐MRI shortly after well‐documented onset (mean time delay 3 h). consisted fluctuating aphasia, mostly associated other subtle...
Proper treatment of hypoxic myoclonic status is not clearly determined. Induced hypothermia improving prognosis and a more aggressive might be beneficial in some patients. Among the new options antiepileptic drugs, perampanel (PER) drug with novel mechanism, it promising for or as an antimyoclonic drug. We describe use PER one patient super-refractory status.A 51-year-old presented after out-of-hospital cardiac arrest due to acute myocardial infarction. The was diagnosed clinical electrical...
Abstract Objective To evaluate the perfusion computed tomography ( PCT ) patterns in patients with status epilepticus SE ). Methods We included consecutive patients, diagnosed by ictal encephalography EEG findings and clinical semiology, who prospectively underwent a dedicated study of phase. The maps were visually analyzed. For quantitative assessment, regions interest areas where suggested abnormalities compared corresponding area unaffected contralateral cortex. Asymmetry indices between...
Los pacientes con síndrome de Down (SD) presentan una demencia tipo Alzheimer (EA) asociada a la edad. Ambas patologías, base neuropatológica común, han sido asociadas epilepsia mioclónica inicio tardío (LOMEDS). Esta entidad presenta alteraciones electroencefalográficas características en forma descargas generalizadas polipunta-onda. Presentamos serie 11 el diagnóstico SD o EA que desarrollaron crisis epilépticas mioclónicas tónico-clónicas generalizadas. En todos ellos, se realizó un...
Spreading depolarization (SD) phenomena are waves of neuronal depolarization, which propagate slowly at a velocity 1 to 5 mm/minute and can occur in patients with ischemic or hemorrhagic stroke, traumatic brain injury, migraine aura. They form part secondary occurring after spreading ischemia. The purposes this study were describe the frequency characteristics SD define whether correlation existed between outcome group TBI large hemispheric stroke.This was prospective observational 39 adult...
Patients with Down syndrome (DS) who exhibit Alzheimer disease (AD) are associated age. Both diseases a common neuropathological basis have been late-onset myoclonic epilepsy (LOMEDS). This entity presents electroencephalogram features as generalised polyspike-wave discharges. We present series of 11 patients the diagnosis DS or AD developed seizures tonic–clonic seizures. In all cases, clinical and neuroimaging studies polygraph EEG monitoring was performed. cognitive impairment progressed...
Purpose To evaluate the clinical features and prognosis of status epilepticus (SE) in patients above 70 years old. Methods Retrospective analysis all ≥70 old with SE registered prospectively during 4 years. Follow-up after discharge was performed. Results Ninety were evaluated. Acute symptomatic etiology most prevalent. The mean number antiepileptic drugs (AEDs) used 2.7 ± 1.2, 21% required sedation. A poor outcome considered when death (31.1%) or developing new neurological impairment at...
To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated perampanel (PER). We present three cases patients refractory SE MELAS syndrome who responded favorably to PER. All were diagnosed as non-convulsive (focal without impairment level consciousness). After an initial treatment other anti-seizure drugs, PER was added in all (8, 16 12 mg) cessation observed within the next 4-8 hours. involved a stroke-like lesion on brain MRI. In...
Valproic acid (VPA) is an effective treatment in juvenile myoclonic epilepsy (JME), but concerns on its use during pregnancy are remarkable. Levetiracetam (LEV) approved as second-line therapy, and used monotherapy clinical practice. Our objective was to analyze the outcome of LEV VPA JME.We analyzed patients with JME attending our unit between 2010 2014, including all treated and/or at some point disease course. The primary end drug retention rate after final analysis.We identified 58 (62%...
Objective To evaluate long-term prognosis in patients with refractory status epilepticus according to the level of sedation reached during drug-induced coma. Materials and Methods Longitudinal study who received anesthetics induce therapeutic Demographic data, clinical, electroencephalographic characteristics were collected, as well variables related sedation. We considered deep EEG burst-suppression patterns (suppression ratio > 50%). A GOSE (Glasgow Outcome Scale Extended) score 7 or 8 was...
The aetiology of epilepsy is an important decisive factor in its treatment and prognosis. Diagnostic therapeutic advances suggest that the causal distribution, prognosis population with may have undergone some modification.To describe distribution syndromes, pharmacological patients epilepsy.We conducted a cross-sectional descriptive study who were treated consecutively our department. Demographic data collected, together information about at time eligibility. analysed jointly by age...
Magnetic resonance imaging (MRI) is commonly used in the diagnostic work-up for status epilepticus (SE). The purpose of this study was to characterize MRI features SE patients and determine their association with clinical electroencephalography (EEG) findings. mid-term consequences baseline were also analysed.This a prospective including consecutive who underwent brain within 240 h after onset. protocol included T1-weighted (T1WI), T2-weighted (T2W), fluid-attenuated inversion recovery...
Abstract Aim . To describe the semiological features in patients suffering with Epilepsia Partialis Continua (EPC), also referred as Kozhevnikov syndrome and their relationship aetiology, duration, prognosis, well recurrence during follow‐up. Methods We analysed consecutive EPC diagnosed followed our centre over a seven‐and‐a half year period. collected demographic clinical data, along neuroimaging EEG recordings. All were for more than six months. Patients categorised single body area or...