Background— Matrix metalloproteinase (MMP) expression is related to blood brain barrier disruption after cerebral ischemia. Moreover, MMP inhibitors reduce hemorrhagic transformation (HT) embolic ischemia in tissue plasminogen activator (t-PA)–treated animals. We aimed correlate plasmatic levels with the appearance of intracranial bleeding complications stroke patients treated t-PA. Methods and Results— Serial MMP-2 MMP-9 determinations were performed (ELISA, ng/mL) 41 strokes involving...

Background and Purpose— Because there is no biologic marker offering precise information about stroke etiology, many patients receive a diagnosis of undetermined even after all available diagnostic tests are done, precluding correct treatment. Methods— To examine the value panel biochemical markers to differentiate etiologies, consecutive acute were prospectively evaluated. Brain computed tomography, ultrasonography, cardiac evaluations, other done identify an etiologic according TOAST...

We sought to investigate the impact of hyperglycemia before reperfusion on long-term outcome in patients treated with intravenous tissue plasminogen activator (tPA).Of 268 consecutive a nonlacunar middle cerebral artery (MCA) stroke evaluated at <3 hours after onset, 73 (27.2%) received tPA. Serum glucose was determined baseline tPA administration. Hyperglycemia defined as level >140 mg/dL. National Institutes Health Stroke Scale (NIHSS) scores were obtained and 24 hours. Transcranial...

Recently, a new definition of transient ischemic attack (TIA) has been proposed based on the duration symptoms and diffusion-weighted imaging (DWI) findings. We investigate value temporal neuroimaging data prognoses TIA patients.Clinical data, symptom duration, DWI, ultrasonographic findings were collected in 83 consecutive classical patients attended emergency department. Stroke recurrence, myocardial infarction, or any vascular event was recorded at follow-up (mean 389 days).A total 27...

Background and Purpose— Hyperglycemia (HG) has a deleterious effect in stroke patients by accelerating ischemic brain damage; moreover, its antifibrinolytic may also influence reperfusion. We aimed to study the of acute/chronic HG on tissue-type plasminogen activator (tPA)–induced recanalization. Methods— studied 139 consecutive with documented intracranial artery occlusion treated intravenous (tPA). Admission glucose levels were recorded (in mg/dL). The existence previous chronic was...

Summary. Development of inhibitors against factor VIII (FVIII) or IX (FIX) in haemophilia patients is one the most serious complications repeated exposure to replacement therapy and has major clinical economic consequences. To evaluate relationship between inhibitor status their quality life (QoL) degree arthropathy compare orthopaedic with/without inhibitors. An observational, cross‐sectional, case control study enrolling: group A ( n = 38), males aged 14–35 years, with severe congenital B...

Background and Purpose— Matrix metalloproteinases (MMPs) are related to blood–brain barrier disruption, some members of this family have been recently involved in brain bleedings. We aimed investigate the temporal profile MMPs their natural inhibitors (TIMPs) after acute intracerebral hemorrhage (ICH) study its influence on neuroimaging clinical outcome. Methods— MMP-2, MMP-9, MMP-3, as well TIMP-1 TIMP-2, were serially determined by enzyme-linked immunosorbent assay admission (&lt;12...

The role of inflammation in intracranial large-artery occlusive disease is unclear. We sought to investigate the relationship between high-sensitivity C-reactive protein (CRP) levels and risk further ischemic events first-ever transient attack (TIA) or stroke patients with disease.Of a total 127 consecutive TIA stenoses detected by transcranial Doppler ultrasonography, 71 fulfilled all inclusion criteria, which included angiographic confirmation. Serum CRP level was determined minimum 3...

Collateral damage may occur in epilepsy management during the coronavirus (COVID-19) pandemic. We aimed to establish impact of this pandemic on patients terms patient-reported seizure control and emerging symptoms.This is a cross-sectional study including consecutive assessed by telephone contact an clinic first month confinement. Demographic clinical characteristics were recorded, 19-item questionnaire was systematically completed. Data regarding confinement, economic effects pandemic,...

Introduction According to the IHCD-3β classification, chronic migraine (CM) is headache occurring on 15 or more days/month. Episodic (EM) can be divided into low frequency (LFEM) and high (HFEM) depending days suffered per month. Methods We performed a clinical comparison of characteristics according monthly suffered. Patients were three groups: LFEM (1-9 days/month), HFEM (10-14 days/month) CM (≥15 days/month). Results The analysis included 1109 patients. Previously reported differences...

Introduction: In addition to clinical factors, blood-based biomarkers can provide useful information on the risk of developing post-stroke epilepsy (PSE). Our aim was identify serum at stroke onset that could contribute predicting patients higher PSE. Patients and methods: From a previous study in which 895 acute were followed-up, 51 developed We selected 15 with PSE controls without epilepsy. biomarker discovery setting, 5 Olink panels 96 proteins each, used determine protein levels....

Background— Growing data point toward intravenous tissue plasminogen activator (tPA) benefit after 3 hours in selected stroke patients. We aim to study safety and efficacy of tPA treatment the 3- 6-hour window using multimodal transcranial Doppler (TCD)/MRI selection criteria. Methods— studied patients with acute middle cerebral artery (MCA) occlusion. Patients within 0 from symptom onset (A) were treated according standard computed tomography Treatment 6 (B) was decided TCD/MRI protocol....

Although statins are being used for secondary prevention of ischemic stroke, recent experimental data have shown new pleiotropic effects these drugs responsible their role in neuroprotection. We conducted a pilot, double‐blind, randomized, multicenter clinical trial to study the first time safety and efficacy simvastatin acute phase stroke. Simvastatin/placebo was given at 3–12 h from symptom onset 60 patients with cortical strokes. Efficacy on evolution several inflammation markers...

Grade 1A recommendations We recommend: The use of restrictive transfusion strategies in nonbleeding, euvolaemic anaemic patients. Perioperative administration tranexamic acid to patients undergoing cardiac surgery. intravenous iron cancer patients, as an adjuvant erythropoiesis-stimulating agents, for correcting chemotherapy-induced anaemia. Preoperative erythropoiesisstimulating agents anaemic, orthopaedic surgical expected have moderate blood losses. do not desmopressin elective critically...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Cognitive decline after stroke is more common than recurrence. Stroke doubles the risk of dementia and a major contributor to vascular cognitive impairment dementia. Nonetheless, few pharmacological studies have addressed stroke. We assessed safety long-term administration its possible efficacy citicoline in preventing poststroke patients with first-ever ischemic &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Open-label, randomized, parallel...

The severity of status epilepticus (SE) has an important impact in clinical outcomes. Status Epilepticus Severity Score (STESS) is a score for predicting mortality SE at admission. baseline modified Rankin Scale (mRS) might be prognostic factor assessing the short-tem outcomes SE. Therefore, our aim was to evaluate effectiveness mRS and whether its addition STESS improves prediction mortality.Consecutive patients with aged >16 years were recruited during 3 years. Receiver operating...

Background and Purpose— The aim of this article was to analyze the likelihood receiving informal care after a stroke study burden risk burnout primary caregivers in Spain. Methods— CONOCES is an epidemiological, observational, prospective, multicenter patients diagnosed with admitted Stroke Unit Spanish healthcare system. At 3 12 months post-event, we estimated time spent caring for patient borne by caregivers. Several multivariate models were applied estimate caregiving, burden, being at...

To evaluate the prevalence and characteristics of headache its relationship with comorbidities lifestyle in a teenage population.This is cross-sectional study. Data was collected from students aged 12-18 years six different schools Catalonia, Spain. They completed an anonymous questionnaire demographic, lifestyle, medical data, presence recurrent headaches features, Strengths Difficulties Questionnaire. We defined probable migraine if presented ≥ 3 ICHD-3 beta criteria for migraine. An...

A livestock-associated clonal lineage (ST398) of methicillin-resistant Staphylococcus aureus (MRSA) has been identified causing colonization or infection in farm workers. The aim the study was to analyze prevalence MRSA-ST398 pigs and pig farmers an area with a high population (Osona, Barcelona province, Catalonia, Spain). We performed cross-sectional Osona (Catalonia, Spain), from June 2014 2015. All workers 83 farms were studied. Twenty these randomly selected for both farmers: 9 fattening...

Lipoprotein (a) (Lp[a]) has important atherothrombogenic properties, but its role in intracranial atherosclerosis remains unclear.To investigate the relationship between Lp(a) level and extent of large-artery occlusive disease.Between June 2001 August 2003, 166 consecutive first-ever TIA or stroke patients had stenoses on transcranial Doppler, which 100 fulfilled all inclusion criteria. The disease was assessed by number angiographically confirmed stenoses. Serum determined a minimum 3...

Symptomatic intracranial hemorrhage (SICH) is the most feared complication after tissue plasminogen activator (tPA) stroke treatment. Endogenous fibrinolysis inhibitors play an essential role in coagulation/fibrinolysis balance and may be involved bleeding process. We aim to determine predictive value of pretreatment levels (PAI-1, lipoprotein(a), TAFI, homocysteine) on SICH.Consecutive tPA-treated patients with middle cerebral artery occlusion were studied. Baseline blood samples obtained...

Statins may exert some neuroprotection, because use before stroke onset has been related to better outcome and reduced mortality. The purpose of this study was evaluate whether patients who receive tissue plasminogen activator have when statins were taken stroke.We evaluated 145 with a involving the middle cerebral artery (who received treatment (<3 hours).Fifty-eight (40%) became functionally independent at 3 months. Factors associated good age (68 versus 74.4 years, P<0.001), baseline...

At present, a rapid and widely available diagnostic test for stroke remains elusive. The aim of this study was to examine the predictive value panel blood-borne biochemical markers diagnosis.Consecutive patients with strokes or stroke-mimicking conditions (mimics) were evaluated within 24 h from symptom onset (915 90 mimics). Blood samples analysed by enzyme-linked immunosorbent assay C-reactive protein, d-dimer, soluble receptor advanced glycation end products (sRAGE), metalloproteinase 9...