A5063015953- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Pharmaceutical studies and practices
- Tuberous Sclerosis Complex Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemoglobinopathies and Related Disorders
- Neurological disorders and treatments
- Polyomavirus and related diseases
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Infectious Encephalopathies and Encephalitis
- Genomics and Rare Diseases
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cardiovascular Syncope and Autonomic Disorders
- Genetics and Neurodevelopmental Disorders
- Bacterial Infections and Vaccines
- Cystic Fibrosis Research Advances
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
Goethe University Frankfurt
2016-2025
University Hospital Frankfurt
2016-2025
University of Glasgow
2025
Philipps University of Marburg
2015-2024
LOEWE Centre for Translational Biodiversity Genomics
2019-2024
Cardiovascular Center Frankfurt
2022-2023
Klinik und Poliklinik für Neurologie
2018-2023
University Hospital of Lausanne
2022
University of Lausanne
2022
Klinikum Osnabrück
2022
Summary Objective Super‐refractory status epilepticus ( SRSE ) is a severe condition in which patient SE for ≥24 h does not respond to first‐, second‐, or third‐line therapy. The economic impact of treatment remains unclear. A health insurance research database was used population‐based estimation ‐associated inpatient costs, length stay, and mortality Germany. Methods An algorithm using International Classification Diseases, 10th Edition coding parameters identified classified patients...
Dravet syndrome is a severe developmental and epileptic encephalopathy characterised by refractory seizures cognitive dysfunction. The treatment challenging, not least because the are highly drug resistant, requiring multiple anti-seizure medications (ASMs), while some ASMs can exacerbate seizures. Initial treatments include broad-spectrum valproate (VPA), clobazam (CLB) in regions; however, they generally insufficient to control With this mind, three adjunct have been approved specifically...
Epilepsy is a serious neurological disorder affecting the quality of life (QoL) people with this condition. A survey was conducted in five European countries (France, Germany, Italy, Spain, and UK) to understand impact burden epilepsy its treatment on lives (PWE).Five hundred PWE (taking >1 antiseizure medication [ASM]) 500 matched controls completed 30-minute online questionnaire. The 12-Item Short Form Survey (SF-12) used measure QoL Neurological Disorders Depression Inventory for (NDDI-E)...
To evaluate long-term outcome of three years and treatment patterns patients suffering from severely drug-refractory epilepsy (SDRE).This analysis was population-based retrospective, with data collected four million individuals insured by statutory German health insurance. ICD-10 codes for (G40*) intake anticonvulsants were used to identify prevalent cases, which then compared a matched cohort drawn the population at large. Insurance available 2008 2013. Any patient who had been prescribed...
Objective To investigate the initial termination rate of status epilepticus (SE) in a large observational study and explore associated variables. Methods Data adults treated for SE were collected prospectively centers Germany, Austria, Switzerland, during 4.5 years. Incident episodes 1,049 patients analyzed using uni‐ multivariate statistics to determine factors predicting cessation within 1 hour (for generalized convulsive [GCSE]) 12 hours non‐GCSE) initiating treatment. Results Median age...
Summary Objective To evaluate factors predicting efficacy, retention, and tolerability of add‐on brivaracetam ( BRV ) in clinical practice. Methods A multicenter, retrospective cohort study recruiting all patients who started between February November 2016 with observation time 3 12 months. Results Of a total 262 (mean age 40, range 5–81 years, 129 male) treated , 227 (87%) were diagnosed to have focal, 19 (7%) idiopathic generalized 8 (3%) symptomatic epilepsy, whereas unclassified. The...
The definition of minimal standards remains pivotal as a basis for high standard care and staff allocation or reimbursement. Only limited publications are available regarding the required staffing methodologic expertise in epilepsy centers. executive board working group (WG) on presurgical diagnosis operative treatment published first guidelines 2000 Austria, Germany, Switzerland. In 2014, revised were WG decided to publish an unaltered English translation this report. Because surgery is...
To provide first data on the cost of epilepsy and cost-driving factors in children, adolescents, their caregivers Germany.A population-based, cross-sectional sample consecutive children adolescents with was evaluated states Hessen Schleswig-Holstein (total 8.796 million inhabitants) all health care sectors 2011. Data socioeconomic status, course epilepsy, direct indirect costs were recorded using patient questionnaires.We collected from 489 (mean age ± SD 10.4 4.2 years, range 0.5-17.8...
The COVID-19 pandemic has caused strains on health systems worldwide disrupting routine hospital services for all non-COVID patients. Within this retrospective study, we analyzed inpatient admissions across 18 German university hospitals during the 2020 lockdown period compared to 2018. Patients admitted between January 1st and May 31st, corresponding periods in 2018 2019 were included study. Data derived from electronic records collected using data integration center infrastructure...
Early prediction of long-term mortality in status epilepticus is important given the high fatality rate years after diagnosis.To improve prognostication diagnosis.This retrospective, multicenter, multinational cohort study analyzed adult patients who were diagnosed with and treated for at university hospitals Odense, Denmark, between January 1, 2008, December 31, 2017, as well Oslo, Norway; Marburg, Germany; Frankfurt, Germany. They aged 18 or older had first-time, nonanoxic epilepticus. A...
Abstract Background Assessment of quality life (QoL) has become an important indicator for chronic neurological diseases. While these conditions often limit personal independence and autonomy, they are also associated with treatment-related problems reduced expectancy. Epilepsy a tremendous impact on the QoL patients their families, which is underestimated by practitioners. The aim this work was to identify relevant factors affecting in adults epilepsy. Methods This cross-sectional,...