A5051473521- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic Neurodegenerative Diseases
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Health
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Cardiac Arrest and Resuscitation
- Advanced Neuroimaging Techniques and Applications
- Linguistic Education and Pedagogy
- Lysosomal Storage Disorders Research
- Advanced MRI Techniques and Applications
- Linguistic research and analysis
- RNA regulation and disease
- Amino Acid Enzymes and Metabolism
- Neonatal Respiratory Health Research
- Herpesvirus Infections and Treatments
- Ethics and Legal Issues in Pediatric Healthcare
Goethe University Frankfurt
2016-2025
Innsbruck Medical University
2024
University Medical Center
2024
Universität Innsbruck
2024
University Hospital Frankfurt
2013-2023
Klinik und Poliklinik für Kinder- und Jugendmedizin
2014-2021
Zentrum für Kinderheilkunde
2001-2020
University of Zurich
2020
Goethe Institute
2012
Medical University of Vienna
2008-2010
Celiac disease (CD), or gluten sensitivity, is considered to be a state of heightened immunologic responsiveness ingested proteins in genetically predisposed individuals. The gastrointestinal manifestation suggests severe enteropathy the small intestine with malabsorption, steatorrhea, and weight loss because deranged mucosal immune response. Neurologic complications occur, especially epilepsy, possibly associated occipital calcifications folate deficiency cerebellar ataxia. There have been...
Summary Objective To examine the attitudes toward counseling about sudden unexpected death in epilepsy ( SUDEP ) and other risk factors among Austrian, German, Swiss neurologists neuropediatricians, to determine associated with not discussing . Methods Questionnaires were sent approximately 5,000 neuropediatricians 2014 regarding respondents’ demographics, their working environments, how often they discussed , suicidal ideations on anticonvulsive medication, driving restrictions, risks daily...
IntroductionDravet syndrome (DS) is a rare developmental and epileptic encephalopathy. This study estimated cost, cost-driving factors quality of life (QoL) in patients with Dravet their caregivers prospective, multicenter Germany.MethodsA validated 3–12-month retrospective questionnaire prospective 3-month diary assessing clinical characteristics, QoL, direct, indirect out-of-pocket (OOP) costs were administered to DS throughout Germany.ResultsCaregivers 93 (mean age 10.1 years, ±7.1, range...
Background The QOLIBRI-KID/ADO-Proxy is the first disease-specific health-related quality of life (HRQoL) proxy questionnaire developed for use in field pediatric traumatic brain injury (TBI), when children are unable to report their HRQoL themselves.
L-asparaginase is frequently used in combination therapy for the treatment of lymphoid malignancies. We report 5 children aged between 8 and 14 years with neurologic complications presenting headache seizures during first three weeks treatment. Three patients had venous thrombosis, one presented a parenchymal hemorrhage, showed peculiar encephalopathy extended cortical subcortical lesions suggesting neurotoxic reaction. Decreased fibrinogen antithrombin III levels were found. Early MRI...
<b>Background:</b> Traumatic stroke usually occurs after dissection of large extracranial or intracranial vessels, leading to disseminated cerebral embolism. Stretching and distorting forces in intraparenchymal end arteries can cause intimal lesions followed by an occluding thrombus. <b>Objective:</b> To investigate the importance traumatic endothelial minor head injuries. <b>Methods:</b> The cases eight children are reported. They were aged between two seven years (mean 6.2 years), they...
To compare direct and indirect costs quality of life (QoL) pediatric adult patients with Dravet syndrome (DS), drug-resistant epilepsy (DRE) in seizure remission (SR), their caregivers, Germany.Questionnaire responses from 93 DS caregivers were matched by age gender DRE SR collected independent studies, compared across main components QoL, (patient visits, medication use, care level, medical equipment, ancillary treatments), (quitting job, reduced working hours, missed days).Mean total...
The subjective impact of the consequences pediatric traumatic brain injury (pTBI) on different life dimensions should be assessed multidimensionally and as sensitively possible using a disease-specific health-related quality (HRQoL) instrument. development psychometrics first such self-report questionnaire for children adolescents after TBI are reported here. Focus group interviews with children, adolescents, their parents, cognitive debriefing, item pool generation reduction Delphi expert...
Until recently, no disease-specific health-related quality of life (HRQoL) questionnaire existed for pediatric traumatic brain injuries (TBIs). In this revalidation study, the psychometric properties and validity 35-item QOLIBRI-KID/ADO in its final German version were examined 300 children adolescents. It is first self-reported TBI-specific tool measuring HRQoL individuals aged between 8 17 years. The six-factor model fits data adequately. questionnaire's internal consistency was excellent...
Despite early diagnosis of traumatic epidural hematomas (EDHs) in children, mortality remained quite high recent series. The aims this analysis were to review the cause and outcome pediatric EDH nowadays discuss outcome-related variables a large consecutive series surgically treated children.This is retrospective case 39 patients (27 males, 69%) with between June 1997 February 2007. Patients' medical records, computed tomographic scans, and, if performed, magnetic resonance imagings reviewed...
Summary Objective Juvenile myoclonic epilepsy ( JME ) has been considered to be a frontal variant of thalamocortical network dysfunction in epilepsy. Changes γ‐aminobutyric acid GABA) ergic neurotransmission may play key role this dysfunction. Magnetic resonance spectroscopy (MRS) is the only noninvasive method measure GABA concentrations different brain regions. We measured and other metabolite thalamus lobe patients with . Methods A specific protocol was used for determining thalamus,...
Ataxia telangiectasia (A-T) is a devastating multi-system disorder characterized by progressive cerebellar ataxia, immunodeficiency, genetic instability, premature aging and growth retardation. Due to better care the patients get older than in past new disease entities like disturbed glucose tolerance liver emerge. The objective of present investigation determine evolution its relation age neurological deterioration. study included 67 aged 1 38 years with classical A-T. At least two...
Ataxia-telangiectasia (A-T) is a devastating human autosomal recessive disorder that causes progressive cerebellar ataxia, immunodeficiency, premature aging, chromosomal instability and increased cancer risk. Affected patients show growth failure, poor weight gain, low body mass index (BMI), myopenia fatigue during adolescence. The prevalence of alterations in composition, muscle strength hormonal status has not been well described classical A-T patients. Additionally, no current guidelines...
Ataxia telangiectasia (A-T) is a rare autosomal-recessive multisystem disorder characterized by pronounced cerebellar ataxia, telangiectasia, cancer predisposition and altered body composition. In addition, evidence rising for endocrine dysfunction.