A5046276382- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Electron Spin Resonance Studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Atomic and Subatomic Physics Research
- NMR spectroscopy and applications
- Stroke Rehabilitation and Recovery
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Nuclear Physics and Applications
- Cardiovascular and exercise physiology
- Coenzyme Q10 studies and effects
Goethe University Frankfurt
2016-2025
University Hospital Frankfurt
2015-2024
Deutschen Konsortium für Translationale Krebsforschung
2020-2024
Frankfurt Cancer Institute
2020-2024
German Cancer Research Center
2016-2024
Heidelberg University
2016-2024
University of Nottingham
2021
Zero to Three
2017
Medizinische Hochschule Hannover
2016
Senckenberg Research Institute and Natural History Museum Frankfurt/M
2016
Mitochondrial dysfunction hypothetically contributes to neuronal degeneration in patients with Parkinson's disease. While several vitro data exist, the measurement of cerebral mitochondrial living disease is challenging. Anatomical magnetic resonance imaging combined phosphorus and proton spectroscopic provides information about functional integrity mitochondria specific brain areas. We measured partial volume corrected concentrations low-energy metabolites high-energy phosphates sufficient...
Abstract Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q 10 (CoQ ) is a physiological cofactor of I. Therefore, we evaluated the short‐term effects CoQ PSP. We performed double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) receive liquid nanodispersion (5 mg/kg/day) or matching placebo. Over 6‐week period, determined change serum concentration, cerebral energy...
Alzheimer's disease (AD) is the most common form of dementia, and it affects more women than men. Mitochondrial dysfunction (MD) plays a key role in AD, detectable at an early stage degenerative process peripheral tissues, such as mononuclear blood cells (PBMCs). However, whether these changes are also reflected cerebral energy metabolism sex-specific differences mitochondrial function occur not clear. Therefore, we estimated correlation between PBMCs brain metabolites examined healthy...
Anti-angiogenic treatment in recurrent glioblastoma patients suppresses contrast enhancement and reduces vasogenic edema while non-enhancing tumor progression is common. Thus, the importance of T2-weighted imaging increasing. We therefore quantified T2 relaxation times, which are basis for image on images.Conventional quantitative MRI procedures were performed 18 with before bevacizumab every 8 weeks thereafter until further progression. segmented conventional into 3 subvolumes: enhancing...
There is mounting evidence that aerobic exercise has a positive effect on cognitive functions in older adults. To date, little known about the neurometabolic and molecular mechanisms underlying this effect. The present study used magnetic resonance spectroscopy quantitative MRI to systematically explore effects of physical activity human brain metabolism grey matter (GM) volume healthy aging. This randomised controlled assessor-blinded two-armed trial (n=53) exercise-induced neuroprotective...
Heating of gradient coils and passive shim components is a common cause instability in the B0 field, especially when intensive sequences are used. The aim study was to set benchmark for typical drift encountered during MR spectroscopy (MRS) assess need real-time field-frequency locking on MRI scanners by comparing field data from large number sites. A standardized protocol developed 80 participating sites using 99 3T 3 major vendors. Phantom water signals were acquired before after an EPI...
Proton MR spectroscopy ((1)H MRS)-visible total choline-containing compounds (tCho-compounds) are derivatives of membrane phospholipids and, in part, may act as a long-term second-messenger system for cellular proliferation. Experimental evidence suggests increasing concentrations tCho-compounds during The present study was conducted order to test the hypothesis that vivo measurements tCho-concentrations using (1)H MRS allow assessment proliferative activity neuroepithelial brain tumors...
Fish embryos represent a class of multicompartmental biological systems that have not been successfully cryopreserved, primarily because the lack understanding how water and cryoprotectants permeate compartments. We are using zebrafish embryo as model to understand these kinetics. Zebrafish two major compartments, blastoderm yolk, which is surrounded by multinucleated yolk syncytial layer (YSL). determined cryoprotectant permeability in compartments methods. First, we measured shrink/swell...
Abstract Diffusion NMR spectroscopy was used to study intracellular volume and apparent water diffusion constants in different cell lines (DU145, human prostate cancer; AT3, rat MCF‐7, breast RIF‐1, mouse fibrosacroma). The cells were grown on various matrices (collagen sponge, collagen beads, polystyrene beads) which enabled continuous growth perfused high density culture suitable for studies. In systems, the attenuation of signal versus squared gradient strength fitted by sum two decaying...
Abstract It is shown that the effect of pH changes can be measured in proton NMR spectra through sensitivity signal intensities metabolite protons exchanging with water. To observe this phenomenon, pulse sequences must used sensitively these exchangeable under physiological conditions, which achieved by avoiding magnetization transfer losses due to water saturation for solvent suppression purposes. These methods provide an order‐of‐magnitude enhancement many signals between 5 and 10 ppm,...
Successful cryopreservation of most multicompartmental biological systems has not been achieved. One prerequisite for success is quantitative information on cryoprotectant permeation into and amongst the compartments. This report describes direct measurements a system using chemical shift selective magnetic resonance (MR) microscopy MR spectroscopy. We used developing zebrafish embryo as model studying these complex because embryos are composed two membrane-limited compartments: (i) large...
Abstract In a prospective study, two‐dimensional 1 H‐MRS with TE of 30 ms was performed before surgery in 56 patients glial brain tumors. Concentrations myo ‐inositol (MI), trimethylamine (TMA) and creatine/phosphocreatine (tCr) were evaluated for the whole tumor scaled to normal‐appearing contralateral tissue. To assign changes MI specific tissue pathology, normalized peak mean concentrations correlated TMA tCr concentrations. is accepted as marker proliferating tissue, might be reactive...
We investigated DTI changes, potentially indicating alterations of microstructure and brain tissue integrity in 13 patients with probable progressive supranuclear palsy (PSP, Richardson syndrome) at stage III or less 10 age-matched controls using a whole analysis diffusion tensor imaging (DTI) data. images were analyzed tract-based spatial statistics, hypothesis-free technique. Fractional anisotropy (FA), radial diffusivity (RD), axial (AD) determined. In PSP, significant increases FA (P <...
(1)H MRSI has evolved as an important tool to study the onset and progression of brain damage in multiple sclerosis. Abnormal increases total creatine, choline myoinositol have been noted However, pathobiochemical mechanisms related these changes are still largely unclear. The combination (1)H-decoupled (31)P can specify what extent phosphorylated components creatine contribute this increase. Combined data were obtained at 3 T 22 patients with sclerosis 23 healthy controls, aligned...
Background: The oral bioavailability of curcuminoids is low, but can be enhanced by incorporation into micelles. major curcuminoid curcumin has antitumor effects on glioblastoma cells in vitro and vivo. We therefore aimed to determine intratumoral concentrations the clinical tolerance highly bioavailable micellar patients. Methods: Thirteen patients ingested 70 mg [57.4 curcumin, 11.2 demethoxycurcumin (DMC), 1.4 bis-demethoxycurcumin (BDMC)] three times per day for 4 days (total amount 689...
ABSTRACT BACKGROUND AND PURPOSE To investigate accumulative aging effects on neurometabolism in human brain and to collect a reference dataset. METHODS Fifty‐four healthy volunteers aged evenly between 22 73 years were studied using whole‐brain 1 H‐MR spectroscopic imaging combination with 31 P‐MRS at 3T. Global metabolite concentrations of N‐acetylaspartate (NAA), total choline (tCho), creatine (tCr), as well phosphocreatine (PCr), adenosine‐5′‐triphosphate (ATP), phosphomonoesters (PME),...
Participating in physical activity and maintaining performance as well reducing sedentary behavior are discussed to be beneficially associated with cognitive function older adults. The purpose of this cross-sectional analysis was differentiate the relevance objectively measured activity, performance, on healthy adults (
Background Emerging evidence suggests that fasting could play a key role in cancer treatment. Its metabolic effects on gliomas require further investigation. Purpose To design multi‐voxel 1 H/ 31 P MR‐spectroscopic imaging (MRSI) protocol for noninvasive monitoring of cerebral, fasting‐induced changes an individual patient/tumor level, and to assess its technical reliability/reproducibility. Study Type Prospective. Population MRS phantom. Twenty‐two patients (mean age = 61, 6 female) with...