A5103164888- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Neuroscience and Neural Engineering
- Diet and metabolism studies
- Ion channel regulation and function
- Atomic and Subatomic Physics Research
- Lipid Membrane Structure and Behavior
- Genetics and Neurodevelopmental Disorders
- Acute Ischemic Stroke Management
- Autoimmune Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Biomedical and Chemical Research
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
Klinik Hietzing
2016-2025
Karl Landsteiner Society
2015-2025
Sigmund Freud University Vienna
2016-2025
Wiener Krankenanstaltenverbund
2022-2025
University of Vienna
1996-2023
Medical University of Vienna
2002-2020
Behörde für Gesundheit und Verbraucherschutz
2020
Ludwig Boltzmann Institut für Epilepsie und Neuromuskuläre Erkrankungen
2001-2020
University Hospital of Zurich
2020
University of Zurich
2019-2020
We propose an epileptic seizure classification based exclusively on ictal semiology. In this semiological (SSC), seizures are classified as follows: a. Auras manifestations having sensory, psychosensory, and experiential symptoms. b. Autonomic in which the main objectively documented autonomic alterations. c. "Dialeptic" have their alteration of consciousness that is independent EEG manifestations. The new term "dialeptic" has been coined to differentiate concept from absence (dialeptic with...
We studied heart-rate (HR) changes at the transition from preictal to ictal state in patients with focal epilepsies gain some insight into mechanisms involved neuronal regulation of cardiovascular function.We assessed ECG during 145 seizures recorded scalp EEG 58 who underwent video-EEG monitoring. Consecutive RR intervals were analyzed a newly developed mathematical method for total 90 s.Ictal-onset tachycardia occurred 86.9% all seizures, whereas bradycardia was documented only 1.4%. The...
Recent evidence suggests that temporal lobe epilepsy affects a neuronal network rather than single circumscribed structure within the lobe. Thus, in mesial (mTLE) with hippocampal sclerosis gray matter abnormalities have been found beyond hippocampus extrahippocampal regions by means of voxel-based morphometry (VBM). On contrary, cryptogenic or MRI-negative TLE (cTLE) no consistent VBM studies reported.We used optimized modulation to detect compared healthy controls patients mTLE and cTLE....
Background and purpose To clarify the relevance of titres IgG antibodies against contactin‐associated protein‐2 (CASPR2) in diagnosing anti‐CASPR2 encephalitis to describe features outcomes. Methods This was a retrospective analysis 64 patients with CASPR2 antibodies, categorized independently as ‘autoimmune encephalitis’ or ‘other disease’. Logistic regression methods were performed identify potential predictors addition antibodies. Results An upfront antibody serum titre cut‐off at ≥1:200...
Inflammatory mechanisms, involving granulocytes, T-cells, B-cells, macrophages and activated microglia, have been suggested to play a pathogenic role in experimental models of stroke may be targets for therapeutic intervention. However, knowledge on the inflammatory response human lesions is limited. Here, we performed quantitative study reaction ischemic infarct lesions. We found increased numbers T-lymphocytes, mainly CD8+ cells, but not B-lymphocytes. Their number was very low comparison...
With a prevalence of 0.8 to 1.2%, epilepsy represents one the most frequent chronic neurological disorders; 30 40% patients suffer from drug-resistant (that is, seizures cannot be controlled adequately with antiepileptic drugs). Epilepsy surgery valuable treatment option for 10 50% these patients. aims control by resection epileptogenic tissue while avoiding neuropsychological and other deficits sparing essential brain areas. The common histopathological findings in specimens are hippocampal...
Zusammenfassung In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster Anfall, Pharmakotherapie, Epilepsiechirurgie, komplementäre supportive Therapieverfahren psychosoziale Aspekte. Beim Thema Leitlinie zunächst zur Unterscheidung beiden maßgeblichen Differenzialdiagnosen, Synkope psychogener nicht-epileptischer gegeben. Zudem wird...
Abstract Objective This study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in localization epileptogenic zone (EZ) as reported published studies, harmonize and facilitate systematic reviews field epilepsy surgery. Methods We conducted Delphi involving 22 experts from 18 countries, who were asked rate their EZ various theoretical clinical scenarios, using different scales. Information provided these scenarios included...
Introduction A novel focal cortex stimulation (FCS) device has recently received approval in Europe for patients with drug-resistant epilepsy (DRE). After 6 months of stimulation, 17 32 achieved ≥50% reduction seizure frequency compared their prestimulation baseline (responders). Currently, there is no established method predicting FCS treatment response prior to implantation. Methods and analysis This an ongoing combined retrospective-prospective non-interventional multicentre study....
Autonomic symptoms frequently occur during epileptic seizures either as an accompaniment to other seizure or the predominant manifestation. They do not represent simple reactions motor manifestations of seizures, but are mediated by activation central autonomic network. can be divided into cardiovascular changes, respiratory manifestations, gastrointestinal symptoms, cutaneous pupillary genital and sexual well urinary symptoms. Due a hemispheric-specific representation network, certain may...
1. A 16-channel electrode array was used to record simultaneously extracellular laminar field potentials evoked by displacement of contralateral vibrissa from vibrissa/barrel cortex in five rats. Current source-density (CSD) analysis combined with principal component (PCA) determine the time course laminar-specific transmembrane currents during response. 2. The potential complex consisted biphasic fast components followed long-lasting slow waves. It began activity supragranular cells...
Marked expression of neuropeptide Y (NPY) and its Y2 receptors in hippocampal mossy fibers has been reported animal models epilepsy. Because NPY can suppress glutamate release by activating presynaptic receptors, these changes have proposed as an endogenous protective mechanism. Therefore, we investigated whether similar the system may also take place human We Y1 receptor binding immunoreactivity specimens that were obtained at surgery from patients with temporal lobe epilepsy autopsy...
Summary: Purpose and Methods: Regional overexpression of the multidrug transporter P‐glycoprotein (P‐gp) in epileptic brain tissue may lower target site concentrations antiepileptic drugs thus contribute to pharmacoresistance epilepsy. We used P‐gp substrate R ‐[ 11 C]verapamil positron emission tomography (PET) test for differences activity between epileptogenic nonepileptogenic regions patients with drug‐resistant unilateral temporal lobe epilepsy (n = 7). compared kinetics homologous...
We studied long-term prognosis and prognostic variables for therapeutic outcome of analgesic withdrawal in 54 patients with drug-induced headaches. The duration headache history was 21.9 +/- 12.8 years. Each patient took an average 38.8 22.8 tablets or suppositories a week 2.5 distinct drugs. Most used drugs containing several components. Caffeine contained at least one drug all cases, ergotamine 80.0% pyrazolone 77.1%. All were admitted to the hospital two weeks. analgesics discontinued...
To assess knowledge of and attitudes toward epilepsy in the Austrian general public to identify independent predictors negative attitudes.A survey consisting a representative sample 2,128 adults was commissioned. A questionnaire similar ones used earlier studies other countries used. The influence socioeconomic variables concepts about on were analyzed by using logistic stepwise regression procedure.Nearly 10% respondents expressed people with epilepsy. These figures are those performed...