A5102811905- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Infectious Encephalopathies and Encephalitis
- Neonatal and fetal brain pathology
- Genetics and Neurodevelopmental Disorders
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Neuropathies and Disorders
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Functional Brain Connectivity Studies
- Bacterial Infections and Vaccines
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Treatment of Major Depression
- Neurological disorders and treatments
- Sepsis Diagnosis and Treatment
- Pregnancy and Medication Impact
University Hospital of Basel
2016-2025
University of Basel
2016-2025
Academic Rights Press (United Kingdom)
2024
University of Helsinki
2024
Helsinki University Hospital
2024
University of Lausanne
2021-2022
University Hospital of Lausanne
2022
Goethe University Frankfurt
2022
Klinikum Osnabrück
2022
University Hospital of Zurich
2006-2021
To evaluate the risks of continuously administered IV anesthetic drugs (IVADs) on outcome adult patients with status epilepticus (SE).All intensive care unit SE from 2005 to 2011 at a tertiary academic medical center were included. Relative calculated for primary measures seizure control, Glasgow Outcome Scale score discharge, and death. Poisson regression models used control possible confounders assess effect modification.Of 171 patients, 37% treated IVADs. Mortality was 18%. Patients had...
Abstract Introduction The pathophysiology of sepsis-associated delirium is not completely understood and the data on cerebral perfusion in sepsis are conflicting. We tested hypothesis that selected serum markers inflammation differ septic patients with without delirium. Methods investigated 23 adult sepsis, severe or shock an extracranial focus infection no history intracranial pathology. Patients were after stabilisation within 48 hours admission to intensive care unit. Sepsis-associated...
Intravenous thrombolysis for acute ischemic stroke is usually based on clinical assessment, blood test results, and CT findings. of mimics may occur but has not been studied in detail.We determined frequency, characteristics, outcome mimic patients versus with treated intravenous using data a prospective, single-center bank.Among 250 patients, 243 (97.2%) had strokes 7 (2.8%) were mimics. Seizure was the most frequent diagnosis among There trend toward lower National Institutes Health Stroke...
Abstract Introduction The Glasgow Coma Scale (GCS) is the most widely used scoring system for comatose patients in intensive care. Limitations of GCS include impossibility to assess verbal score intubated or aphasic patients, and an inconsistent inter-rater reliability. FOUR (Full Outline UnResponsiveness) score, a new coma scale not reliant on response, was recently proposed. aim present study compare reliability among unselected general critical A further neurologists with that care unit...
Summary Purpose Refractory status epilepticus ( RSE ) is a life‐threatening neurologic emergency with high mortality and morbidity. The aim of this study was to identify quantify associations between clinical characteristics adult patients outcome. Methods Comprehensive medical chart review performed all consecutive treated on the intensive care units an academic tertiary center 2005 2011. Demographics, etiologies duration, comorbidities, as well outcomes were assessed. Associations death...
In critically ill patients with altered consciousness, continuous electroencephalogram (cEEG) improves seizure detection, but is resource-consuming compared routine EEG (rEEG). It also uncertain whether cEEG has an effect on outcome.To assess associated reduced mortality rEEG.The pragmatic multicenter Continuous Randomized Trial in Adults (CERTA) was conducted between 2017 and 2018, follow-up of 6 months. Outcomes were assessed by interviewers blinded to interventions.The study took place at...
Objectives: A clinical scoring system for patients with status epilepticus was developed predicting outcome, planning the level of monitoring needed, and guiding treatment. The aim to confirm external validity transportability Status Epilepticus Severity Score prediction functions outcome in adult epilepticus. Design: Observational cohort study. Setting: Tertiary academic medical care center. Patients: Consecutive ICU Interventions: None. Measurements Main Results: History seizures, age,...
Objective To investigate the initial termination rate of status epilepticus (SE) in a large observational study and explore associated variables. Methods Data adults treated for SE were collected prospectively centers Germany, Austria, Switzerland, during 4.5 years. Incident episodes 1,049 patients analyzed using uni‐ multivariate statistics to determine factors predicting cessation within 1 hour (for generalized convulsive [GCSE]) 12 hours non‐GCSE) initiating treatment. Results Median age...
There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID‐19), but little known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) a specific biomarker neuronal injury. We measured sNfL concentrations 29 critically ill COVID‐19 patients, 10 non–COVID‐19 and 259 healthy controls. After adjusting comorbidities age, were higher in patients with versus both comparator groups. Higher...
<h3>Objective:</h3> To investigate the frequency of induced electroencephalographic (EEG) burst-suppression pattern during continuous intravenous anesthesia (IVAD) and associated outcomes in adult patients treated for refractory status epilepticus (RSE). <h3>Methods:</h3> Patients with RSE anesthetics at a Swiss academic care center from 2011-2019 were included. Clinical data semiquantitative EEG analyses assessed. Burst-suppression was categorized as incomplete (with ≥20% <50%...
Zusammenfassung In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster Anfall, Pharmakotherapie, Epilepsiechirurgie, komplementäre supportive Therapieverfahren psychosoziale Aspekte. Beim Thema Leitlinie zunächst zur Unterscheidung beiden maßgeblichen Differenzialdiagnosen, Synkope psychogener nicht-epileptischer gegeben. Zudem wird...
Status epilepticus (SE) is an important neurologic emergency requiring treatment on intensive care unit (ICU). Although convulsive SE self-evident, the diagnosis of nonconvulsive (NCSE) depends electroencephalography (EEG) confirmation. Previous work showed that 82% patients with had NCSE in our ICU. We hypothesize continuous video-EEG monitoring (CVEM) may increase diagnostic yield SE, especially NCSE, and leave fewer undiagnosed.We retrospectively assessed EEG reports 537 suspected during...
Objective To assess the association between incident Parkinson disease (PD) and subsequent epileptic seizures. Methods We conducted a retrospective cohort study with nested case–control analysis using data from U.K. Clinical Practice Research Datalink. identified patients aged ≥40 years an diagnosis of PD 1995 2016 matched comparison group PD‐free individuals. calculated crude incidence rates (IRs) 95% confidence intervals (CIs) seizures in group, corresponding rate ratios (IRRs). In...
Summary Objective Older antiepileptic drugs ( AEDs ) are known to cause Stevens‐Johnson syndrome and toxic epidermal necrolysis SJS / TEN ). However, evidence for newer AED is sparse. We quantified risks of in association with use all s the United Kingdom. Methods In a matched case‐control study 480 previously validated cases (1995–2013) we used conditional logistic regression calculate odds ratios ORs 95% confidence intervals CIs ), calculated absolute within separate cohorts new users 28...