A5013827938- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and Mental Health
- Cardiac electrophysiology and arrhythmias
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Effects of Exercise
- Hormonal Regulation and Hypertension
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Redox biology and oxidative stress
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Ischemia and Reperfusion
- RNA Research and Splicing
- Heart Failure Treatment and Management
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- MicroRNA in disease regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Signaling Pathways in Disease
- Sports injuries and prevention
University Hospital of Basel
2013-2025
University of Basel
2013-2025
Cardiovascular Institute Hospital
2022
University Hospital of Lausanne
2021
University of Lausanne
2021
Hirslanden Klinik Im Park
2021
Hôpital de Morges
2021
Luzerner Kantonsspital
2021
Zurich Heart House
2021
Brigham and Women's Hospital
2016
Abstract
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
Titin, the largest myofilament protein, serves as a template for sarcomere assembly and acts molecular spring to contribute diastolic function. Titin is known be extremely susceptible calcium-dependent protease degradation in vitro. We hypothesized that titin an early event doxorubicin-induced cardiac injury occurs by activation of proteases, calpains. Treatment cultured adult rat cardiomyocytes with 1 or 3 μmol/liter doxorubicin 24 h resulted myocyte lysates, which was confirmed reduction...
<h3>Context</h3> The risk-benefit ratio of invasive vs medical management elderly patients with symptomatic chronic coronary artery disease (CAD) is unclear. Trial Invasive versus Medical therapy in Elderly (TIME) recently showed early benefits quality life from aged 75 years or older, although a certain excess mortality. <h3>Objective</h3> To assess the long-term value CAD adults terms and prevention major adverse cardiac events. <h3>Design</h3> One-year follow-up analysis TIME, prospective...
Background— Although aldosterone, acting via mineralocorticoid receptors, causes left ventricular (LV) hypertrophy in experimental models of high-aldosterone hypertension, little is known about the role aldosterone or receptors mediating adverse remodeling response to chronic pressure overload. Methods and Results— We used receptor–selective antagonist eplerenone (EPL) test transition from failure mice with overload caused by ascending aortic constriction (AAC). One week after AAC, were...
Background A hallmark of aging the cardiac myocyte is impaired sarcoplasmic reticulum ( SR ) calcium uptake and relaxation due to decreased ATP ase SERCA activity. We tested hypothesis that H 2 O ‐mediated oxidation contributes in aging. Methods Results Young (5‐month‐old) senescent (21‐month‐old) FVB wild‐type (WT) or transgenic mice with myocyte‐specific overexpression catalase were studied. In mice, (1) prevented oxidative modification as evidenced by sulfonation at Cys674, (2) preserved...
There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID‐19), but little known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) a specific biomarker neuronal injury. We measured sNfL concentrations 29 critically ill COVID‐19 patients, 10 non–COVID‐19 and 259 healthy controls. After adjusting comorbidities age, were higher in patients with versus both comparator groups. Higher...
The pandemic of coronavirus disease (COVID-19) has rapidly spread globally and infected millions people. prevalence prognostic impact dysnatremia in COVID-19 is inconclusive. Therefore, we investigated the outcome COVID-19.The prospective, observational, cohort study included consecutive patients with clinical suspicion triaged to a Swiss Emergency Department between March July 2020.Collected data clinical, laboratory severity scoring parameters on admission. cases were identified based...
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the sex gender in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients hospitalised patients PCR-confirmed infection. Results Among...
Matrix metalloproteinases (MMPs), aldosterone, and reactive oxygen species (ROS) are implicated in myocardial remodeling. Although ROS, cytokines, neurohormones regulate MMP cardiac fibroblasts, it is unknown whether aldosterone regulates cardiomyocytes. Therefore, we tested the hypothesis that cultured adult rat ventricular myocytes (ARVMs). ARVMs were treated with for 24 hours, MMP-2 MMP-9 activities measured by zymography. Aldosterone (50 nmol/L) increased (43+/-5%) (55+/-15%; P<0.001...
Background— α-Adrenergic receptor (αAR)–stimulated hypertrophy in adult rat ventricular myocytes is mediated by reactive oxygen species–dependent activation of the Ras-Raf-MEK1/2-ERK1/2 signaling pathway. Because Ras known to have redox-sensitive cysteine residues, we tested hypothesis that αAR-stimulated hypertrophic via oxidative modification thiols. Methods and Results— The effect αAR stimulation on number free thiols was measured with biotinylated iodoacetamide labeling. caused a 48%...
Inflammatory biomarkers are associated with severity of coronavirus disease 2019 (COVID-19). However, direct comparisons their utility in COVID-19 versus other respiratory infections largely missing.We aimed to investigate the prognostic various inflammatory compared patients infections.Patients presenting emergency department symptoms suggestive were prospectively enrolled. Levels Interleukin-6 (IL-6), c-reactive protein (CRP), procalcitonin, ferritin, and leukocytes between COVID-19, viral...
Rationale: Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. Objectives: To assess whether IgA autoantibodies target lung-specific proteins and contribute severity. Methods: We collected 147 blood, 9 lung tissue, 36 BAL fluid samples from three tertiary hospitals in Switzerland one Germany. Severe COVID-19 was defined by the need...
Background: Arrhythmogenic Cardiomyopathy (ACM) is one of the major causes sudden cardiac death in young adults. With underlying patho-mechanisms not well understood, current therapeutic approaches for this genetic disease are solely symptomatic. A recent study demonstrates that loss cell-cell adhesion an important initial step leading to ACM. Because considered a key step, we aim identify new compounds from drug library, which can restore intercellular and potentially serve as therapeutics...
Hyperlipidemia is common in renal allograft recipients. To elucidate the role of cyclosporine posttrans-plant hyperlipidemia, we measured lipids, lipoprotein and apolipoproteins thirty-five recipients evaluated their relation to trough blood levels. All patients were on a triple immunosuppressive regimen with equal doses prednisone azathioprine, had stable graft function. Cyclosporine levels significantly correlated total plasma cholesterol (P=0.028), low-density (P=0.022), apolipoprotein B...
Hyperlipidemia is common in renal allograft recipients. To elucidate the role of cyclosporine posttrans-plant hyperlipidemia, we measured lipids, lipoprotein and apolipoproteins thirty-five recipients evaluated their relation to trough blood levels. All patients were on a triple immunosuppressive regimen with equal doses prednisone azathioprine, had stable graft function. Cyclosporine levels significantly correlated total plasma cholesterol (P=0.028), low-density (P=0.022), apolipoprotein B...
Abstract Background Women are overrepresented amongst individuals suffering from post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Methods Findings By using Bayesian models comprising >200 co-variates, we assessed the social context in addition to biological data a multi-centre prospective cohort study 2927 (46% women) Switzerland. more...
Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of cardiomyocytes with fibrofatty tissue replacement, systolic dysfunction, and life-threatening arrhythmias. A substantial proportion ACM caused mutations in genes the desmosomal cell-cell adhesion complex, but underlying mechanisms are not well understood. In current study, we investigated relevance defective for development progression.We mutated binding site DSG2 (desmoglein-2), a crucial molecule cardiomyocytes....