A5028463459- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- COVID-19 and Mental Health
- Biosensors and Analytical Detection
- Streptococcal Infections and Treatments
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- Advanced Chemical Sensor Technologies
- Infection Control and Ventilation
- HIV/AIDS drug development and treatment
- Nosocomial Infections in ICU
- COVID-19 and healthcare impacts
- Burn Injury Management and Outcomes
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Dental Research and COVID-19
- Central Venous Catheters and Hemodialysis
- Advanced biosensing and bioanalysis techniques
- Probiotics and Fermented Foods
University of Zurich
2020-2025
University Hospital of Zurich
2020-2025
Population Health Research Institute
2023-2025
Hamilton Health Sciences
2023-2025
McMaster University
2023-2025
Oregon Medical Research Center
2024
New York Proton Center
2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2024
Lindsay Unified School District
2024
Autoantibodies neutralizing the antiviral action of type I interferons (IFNs) have been associated with predisposition to severe Coronavirus Disease 2019 (COVID-19). Here, we screened for such autoantibodies in 103 critically ill COVID-19 patients a tertiary intensive care unit (ICU) Switzerland. Eleven (10.7%), but no healthy donors, had anti-IFNα or anti-IFNα/anti-IFNω IgG plasma/serum, anti-IFN IgM IgA was rare. One patient non-neutralizing IgG. Strikingly, all plasma also...
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the sex gender in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients hospitalised patients PCR-confirmed infection. Results Among...
Rising demands for repetitive SARS-CoV-2 screens and mass testing necessitate additional test strategies. Saliva may serve as an alternative to nasopharyngeal swab (NPS) its collection is simple, non-invasive amenable mass- home testing, but rigorous validation, particularly in children, missing. We conducted a large-scale head-to-head comparison of detection by RT-PCR saliva NPS 1270 adults children reporting outpatient centers emergency unit. In total, 273 individuals were tested positive...
COVID-19 displays diverse disease severities and symptoms including acute systemic inflammation hypercytokinemia, with subsequent dysregulation of immune cells. Bacterial superinfections in can further complicate the course are associated increased mortality. However, there is limited understanding how SARS-CoV-2 pathogenesis hypercytokinemia impede innate function against bacterial superinfections. We assessed influence plasma on functional responses myeloid cells upon challenges from...
Rationale: Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. Objectives: To assess whether IgA autoantibodies target lung-specific proteins and contribute severity. Methods: We collected 147 blood, 9 lung tissue, 36 BAL fluid samples from three tertiary hospitals in Switzerland one Germany. Severe COVID-19 was defined by the need...
Background Patients in burn centres are at high risk of acquiring multidrug-resistant pathogens due to reduced skin barrier and long hospital stay. Methods We report the investigation control an outbreak Acinetobacter baumannii a centre. The 27 patients hospitalized centre during were regularly screened total 132 environmental samples performed identify potential source. Fourier-transform infrared (FT-IR) spectroscopy multilocus sequence typing (MLST) applied characterise strain. Results...
ABSTRACT Background Multidrug-resistant Pseudomonas aeruginosa (MDRPA) poses significant challenges in hospital settings. Understanding the effects of unprecedented changes brought by COVID-19 pandemic on antimicrobial resistance P. (PA) is essential to inform stewardship efforts. This study investigated dynamics PA bacteremia after start pandemic. Methods single-centre retrospective cohort included adult inpatients with bacteraemia at University Hospital Zurich between January 2014 and...
Abstract Background Sternal surgical site infections (s-SSI) after cardiac surgery can lead to significant morbidity, mortality, and costs. Among patients, the effects of negative pressure wound management is unknown.Table 1:Baseline CharacteristicsBMI= Body Mass Index; COPD= Chronic obstructive pulmonary disease; CABG= Coronary artery bypass graft; SD= Standard deviation Methods The PICS-PREVENA Vanguard study, a 2x2 factorial, open label, cluster-randomized crossover trial, was conducted...
Despite the rising challenge of antibiotic resistance, current approaches to eradicate nasal pathobionts Staphylococcus aureus and Streptococcus pneumoniae rely on antibacterials. An alternative is artificial inoculation commensal bacteria, i.e., probiotic treatment, supported by increasing evidence for commensal-mediated inhibition pathogens. To systematically investigate potential this approach, we developed a quantitative framework simulating microbiome dynamics combining mathematical...
Abstract Background Women are overrepresented amongst individuals suffering from post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Methods Findings By using Bayesian models comprising >200 co-variates, we assessed the social context in addition to biological data a multi-centre prospective cohort study 2927 (46% women) Switzerland. more...
Critically ill coronavirus disease 2019 (COVID-19) patients are characterised by a severely dysregulated cytokine profile and elevated neutrophil counts, impacting severity. However, it remains unclear how neutrophils contribute to pathophysiology during COVID-19. Here, we assessed the impact of on regulated cell death (RCD) programme neutrophils.Regulated phenotype isolated from critically COVID-19 or healthy donors stimulated with plasma ex vivo was flow cytometry, time-lapse microscopy...
The B.1.1.529 (omicron) variant has rapidly supplanted most other SARS-CoV-2 variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized and IgG concentration in the plasma of 39 individuals with multiple trajectories infection and/or vaccination. Antibody was similar against wild-type, delta, omicron variants (
Abstract Background Starting combination antiretroviral therapy (cART) during primary human immunodeficiency virus type 1 (HIV-1) infection results in a smaller HIV-1 latent reservoir, reduced immune activation, and less viral diversity compared to starting cART chronic infection. We report of 4-year study designed determine whether these properties would allow sustained virological suppression after simplification dolutegravir (DTG) monotherapy. Methods EARLY-SIMPLIFIED is randomized,...
Group A Streptococcus (GAS, aka pyogenes) poses a significant public health concern, causing diverse spectrum of infections with high mortality rates. Following the COVID-19 pandemic, resurgence invasive GAS (iGAS) has been documented, necessitating efficient outbreak detection methods. Whole genome sequencing (WGS) serves as gold standard for molecular typing, albeit constrained by time and costs. This study aimed to characterize post-pandemic increased prevalence iGAS on epidemiological...
Switzerland began a national lockdown on March 16, 2020, in response to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed prevalence SARS-CoV-2 infection among patients admitted 4 hospitals canton Zurich, Switzerland, April 2020. These care screened 2,807 patients, including 2,278 (81.2%) who did not have symptoms disease (COVID-19). Overall, 529 (18.8%) persons had >1 symptom COVID-19, whom 60 (11.3%) tested positive for SARS-CoV-2. Eight...
Vancomycin-resistant Enterococci, mainly Enterococcus faecium (VREfm), are causing nosocomial infections and outbreaks. Bacterial typing methods used to assist in outbreak investigations. Most of them, especially genotypic like multi-locus sequence (MLST), whole genome sequencing (WGS), or pulsed-field gel electrophoresis, quite expensive time-consuming. Fourier-transform infrared (FT-IR) spectroscopy assesses the biochemical composition bacteria, such as carboxyl groups polysaccharides. It...
Knowledge of the interplay between human coronavirus (HCoV) immunity and severe acute respiratory syndrome type 2 (SARS-CoV-2) infection is critical to understanding coexistence current endemic coronaviruses building knowledge potential future zoonotic transmissions. This study, which retrospectively analyzed a large cohort individuals first exposed SARS-CoV-2 in Switzerland 2020–2021, revealed several key findings. Pre-existing HCoV immunity, particularly mucosal antibody responses, played...
Abstract Of 1,118 patients with COVID-19 at a university hospital in Switzerland during October 2020–June 2021, we found 83 (7.4%) had probable or definite healthcare-associated COVID-19. After in-hospital exposure, estimated secondary attack rate 23.3%. Transmission was associated longer contact times and lower cycle threshold values among index patients.
Abstract The majority of SARS-CoV-2 transmissions originates from either asymptomatic or presymptomatic individuals. To prevent unnoticed introduction SARS-CoV-2, many hospitals have implemented universal admission screening during the COVID-19 pandemic. present study aimed to investigate associations between results an and public incidence. Over a period 44 weeks, all patients admitted large tertiary care hospital were tested for by polymerase chain reaction. positive retrospectively...
Early identification and isolation of SARS-CoV-2-infected individuals is central to contain the COVID-19 pandemic. Nasopharyngeal swabs (NPS) serve as a specimen for detection by RT-PCR rapid antigen screening tests. Saliva has been confirmed reliable alternative shown be valuable diagnosing children in repetitive mass testing due its non-invasive collection. Combining advantages saliva with those tests would highly attractive further increase test capacities. Here, we evaluated performance...
Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment infections. In this study, we show that secondary electrospray ionization-high resolution mass spectrometry (SESI-HRMS) can be used as a diagnostic tool bacterial infections supportive system current state-of-the-art diagnostics. Volatile organic compounds (VOCs) produced by growing S. aureus or pneumoniae cultures on blood agar plates were detected within minutes allowed the...