A5069462087- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Healthcare Regulation
- COVID-19 diagnosis using AI
- Innovation and Socioeconomic Development
- SARS-CoV-2 and COVID-19 Research
- Health, Nursing, Elderly Care
- Vaccine Coverage and Hesitancy
- HIV/AIDS Impact and Responses
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
- Long-Term Effects of COVID-19
- Chemokine receptors and signaling
University of Zurich
2005-2024
Global HIV Vaccine Enterprise
2010-2019
University Hospital of Zurich
2003-2007
University of Neuchâtel
2003
Ono Pharmaceutical (United States)
2003
Cornell University
2003
New York University
2003
Carnegie Institution for Science
2003
Stanford University
2003
University of Fribourg
2003
Background To explore the possibility that antibody-mediated complement lysis contributes to viremia control in HIV-1 infection, we measured activity of patient plasma mediating autologous primary virus. Methods and Findings Sera from two groups patients—25 with acute infection 31 chronic infection—were used this study. We developed a novel real-time PCR-based assay strategy allows reliable sensitive quantification virus by complement. Plasma derived at time isolation induced isolate...
Rising demands for repetitive SARS-CoV-2 screens and mass testing necessitate additional test strategies. Saliva may serve as an alternative to nasopharyngeal swab (NPS) its collection is simple, non-invasive amenable mass- home testing, but rigorous validation, particularly in children, missing. We conducted a large-scale head-to-head comparison of detection by RT-PCR saliva NPS 1270 adults children reporting outpatient centers emergency unit. In total, 273 individuals were tested positive...
Recently, passive immunization of human immunodeficiency virus (HIV)-infected individuals with monoclonal antibodies (MAbs) 2G12, 2F5, and 4E10 provided evidence the in vivo activity 2G12 but raised concerns about function two membrane-proximal external region (MPER)-specific MAbs (A. Trkola, H. Kuster, P. Rusert, B. Joos, M. Fischer, C. Leemann, A. Manrique, Huber, Rehr, Oxenius, R. Weber, G. Stiegler, Vcelar, Katinger, L. Aceto, F. Gunthard, Nat. Med. 11:615-622, 2005). In light...
Abstract In a differential screening between Arabidopsis plants pretreated with the resistance-inducer β-aminobutyric acid and untreated control plants, we have identified gene encoding novel lipase-like protein, PRLIP1. The abundance of PRLIP1 mRNAs in leaves was up-regulated by application acid, salicylic (SA), ethylene as well various pathogens. Induction depended on functioning SA signal transduction pathway but independent jasmonate signaling. This pathogenesis-related (PR) belongs to...
Knowledge of the interplay between human coronavirus (HCoV) immunity and severe acute respiratory syndrome type 2 (SARS-CoV-2) infection is critical to understanding coexistence current endemic coronaviruses building knowledge potential future zoonotic transmissions. This study, which retrospectively analyzed a large cohort individuals first exposed SARS-CoV-2 in Switzerland 2020–2021, revealed several key findings. Pre-existing HCoV immunity, particularly mucosal antibody responses, played...
Early identification and isolation of SARS-CoV-2-infected individuals is central to contain the COVID-19 pandemic. Nasopharyngeal swabs (NPS) serve as a specimen for detection by RT-PCR rapid antigen screening tests. Saliva has been confirmed reliable alternative shown be valuable diagnosing children in repetitive mass testing due its non-invasive collection. Combining advantages saliva with those tests would highly attractive further increase test capacities. Here, we evaluated performance...
Empirical testing of candidate vaccines has led to the successful development a number lifesaving vaccines. The advent new tools manipulate antigens and methods vectors for vaccine delivery veritable explosion potential designs. As result, selection suitable large-scale efficacy become more challenging. This is especially true diseases such as dengue, HIV, tuberculosis where there no validated animal model or correlate immune protection. Establishing guidelines candidates advanced necessity....
Well-defined correlates of protective immunity are an essential component rational vaccine development. Despite years basic science and three HIV efficacy trials, immunological protection from infection remain undefined. In December 2010, a meeting scientists engaged in translational work toward developing HIV-1 vaccines was convened. The goal this to discuss current opportunities optimal approaches for defining protection, both ongoing future candidates; specific efforts were made engage...
The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing prevention research, responding a growing consensus that effective and durable will require combination of approaches as well unprecedented collaboration among scientists, practitioners, community workers from different fields geographic areas. theme in 2018, "From Impact," acknowledged an increasing focus on translation promising research findings into practical, accessible, affordable options those who need them...
Abstract Broadly neutralizing antibodies (bnAbs) recognizing a diversity of HIV-1 strains are widely thought to be essential for an vaccine. Extensive knowledge on bnAbs has been gained from studying natural HIV infection by following bnAb evolution in individual people with (PWH). However, it remains increase responses large PWH cohorts assess the feasibility inducing activity vaccination. To allow systematic analysis, we created XbnAb cohort, bnAb-inducer cohort selected screening plasma...
Abstract Background RT-PCR of nasopharyngeal swabs (NPS) is the acknowledged gold standard for detection SARS-CoV-2 infection. Rising demands repetitive screens and mass-testing necessitate, however, development additional test strategies. Saliva may serve as an alternative to NPS its collection simple, non-invasive amenable mass- home-testing but rigorous validation saliva particularly in children missing. Methods We conducted a large-scale head-to-head comparison by swab 1270 adults...