A5077441882- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- Hepatitis B Virus Studies
- Travel-related health issues
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Adolescent Sexual and Reproductive Health
- Infectious Diseases and Tuberculosis
- Mosquito-borne diseases and control
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
University of Zurich
2016-2025
University Hospital of Zurich
2015-2024
University Hospital of Bern
2013-2024
University of Bern
2014-2024
Prevention Institute
2020-2024
University of Basel
2009-2024
University Hospital of Geneva
2018-2024
University of Geneva
2019-2024
Swiss Red Cross
2024
University Hospital Bonn
2023-2024
Acute leukopenia occurs in all patients during the first hour of hemodialysis with cellophanemembrane equipment. This transient cytopenia specifically involves granulocytes and monocytes, cells which share plasma membrane reactivity towards activated complement components. The present studies document that is exposure to dialyzer cellophane, upon reinfusion this into venous circulation, granulocyte monocyte entrapment pulmonary vasculature induced. During early dialysis, conversion both C3...
Longer-term consequences after SARS-CoV-2 infection are becoming an important burden to societies and healthcare systems. Data on post-COVID-19 syndrome in the general population required for timely planning of services resources. The objective this study was assess prevalence impaired health status physical mental symptoms among individuals at least six months infection, characterize their utilization. This population-based prospective cohort (Zurich Cohort) enrolled 431 adults from with...
Novel direct antiviral agents (DAA) targeting hepatitis C virus (HCV) have revolutionized the treatment of chronic infection (CHC). Rates sustained virological response (SVR) to drastically improved since introduction DAA. Transient Elastography (TE) is an ultrasound based, non-invasive technique assess liver stiffness (LS). We examined changes in TE values and fibrosis scores FIB-4 APRI after DAA CHC.549 patients who received a based for CHC were screened 392 included. recorded prior...
To evaluate longer term symptoms and health outcomes associated with post-covid-19 condition within a cohort of individuals SARS-CoV-2 infection.Population based, longitudinal cohort.General population canton Zurich, Switzerland.1106 adults confirmed infection who were not vaccinated before 628 did have an infection.Trajectories self-reported status covid-19 related between months six, 12, 18, 24 after excess risk at six compared had no infection.22.9% (95% confidence interval 20.4% to...
Evidence on the impact of post COVID-19 condition (PCC) work ability is limited but critical due to its high prevalence among working-age individuals. This study aimed evaluate association between PCC, ability, and occupational changes in a population-based cohort.We used data from adults included prospective, longitudinal cohort random sample all individuals infected with SARS-CoV-2 August 2020 January 2021 Canton Zurich, Switzerland. We evaluated current related physical mental demands,...
Abstract Background Advancements in access to antiretroviral therapy (ART) and human immunodeficiency virus (HIV) care have led a decline AIDS-related deaths among people with HIV (PWH) Switzerland. However, data on the ongoing changes causes of death PWH over past 15 years are scarce. Methods We investigated all reported Swiss Cohort Study between 2005 2022. Causes were categorized using Coding Death protocol. The statistical analysis included demographic stratification identify time trends...
In an attempt to understand the regulatory mechanisms governing passage of neutrophils from vascular bed interstitial tissue, we analyzed effect pleiotropic monokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) on transendothelial neutrophil traffic. Short-time preincubation human umbilical vein endothelial cell (HUVE) monolayers with IL-1 TNF led impressive time- dose-dependent increase cell-associated when working in a full plasma system petri dishes. Electron microscopic analysis...
Seven cases of agranulocytosis and two liver damage that were probably due to amodiaquine treatment studied. In five was combined with damage, in one case primary moderate neutropenia present. Three patients died. High total doses or prolonged duration treatment, both, appear favour the occurrence these reactions. The clustering seven within six months medical centre indicates risk benefit ratio for malaria prophylaxis should be re-evaluated.
Abstract The mechanism leading to selective accumulation of eosinophils in allergic inflamed tissue is still unknown. In this article, transendothelial migration circulating from normal and individuals characterized by means human umbilical vein endothelial cells cultivated on extracellular matrix fibroblasts. IL-4 pretreatment these vascular constructs induced adherence impressive layer penetration but not neutrophils. For penetration, blood nonallergic donors needed vitro priming...
It has previously been shown that during degranulation Mac-1 (CD11b/CD18)--a glycoprotein plays a central role in neutrophil adhesion-is up-regulated on PMN surfaces. assumed this quantitative change adhesion Ag expression the cell surface would turn lead to increased cellular adhesiveness. In contrast, we found at an incubation temperature of 16 degrees C, stimulated plastic tissue culture dishes presence FMLP (2.5 x 10(-6) M), TNF (10 ng/ml), or PAF (1 10(-4) M) occurred without...
To study mechanisms and mediators regulating the distribution of intravascular granulocytes between circulating marginated pools, a human model with extreme transient margination, neutropenia continuous flow filtration leukophoresis, was analyzed. Studies in animals demonstrated existence complement (C)-derived granulocytopenia-inducing factor. Thus, autologous plasma, exposed to nylon fibers (NF) system, produced an acute selective decrement monocytes. This phenomenon blocked by...
Abstract The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with size long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for median of 5.4 years. At population level, decreases diminishing differences over time, but increases 26.6% individuals. Viral blips low-level viremia are significantly slower decay. Initiation ART within first year infection, pretreatment load, ethnicity affect size, less so dynamics....
Methods. An international, randomized, double-blind, double-dummy, active-controlled trial was conducted to evaluate the efficacy and safety of COBI versus ritonavir (RTV) as a pharmacoenhancer atazanavir (ATV) in combination with emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) treatment-naive patients. The primary end point human immunodeficiency virus type 1 (HIV-1) RNA load <50 copies/mL at week 48 by Food Drug Administration snapshot algorithm; noninferiority margin 12%.
The antiviral potency of the cytokine IFN-α has been long appreciated but remains poorly understood. A number studies have suggested that induction apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) and bone marrow stromal cell antigen 2 (BST-2/tetherin/CD317) retroviral restriction factors underlies IFN-α–mediated suppression HIV-1 replication in vitro. We sought to characterize as-yet-undefined relationship between treatment, factors, vivo. APOBEC3G, APOBEC3F, BST-2...
Bacterial factors may contribute to the global emergence and spread of drug-resistant tuberculosis (TB). Only a few studies have reported on interactions between different bacterial factors. We studied Mycobacterium isolates from nationwide study conducted 2000 2008 in Switzerland. determined quantitative drug resistance levels first-line drugs by using Bactec MGIT-960 genotypes sequencing hot-spot regions relevant genes. recent transmission molecular methods collected clinical data....
ABSTRACT Immigrants from regions with a high incidence of tuberculosis (TB) are risk group for TB in low-incidence countries such as Switzerland. In previous analysis nationwide collection 520 Mycobacterium isolates 2000 to 2008, we identified 35 clusters comprising 90 patients based on standard genotyping (24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat [MIRU-VNTR] typing and spoligotyping). Here, used whole-genome sequencing (WGS) revisit these...
Based on notification data the impact of COVID-19 lockdown in Switzerland was assessed. While incidence tick-borne encephalitis almost doubled as compared to 2016-2019, a reduction all other infectious diseases recorded. The lowest rates (<25%) were noted for legionellosis, hepatitis A, chlamydia infection and gonorrhoea.
Abstract Objectives Seroprevalence studies to assess the spread of SARS-CoV-2 infection in general population and subgroups are key for evaluating mitigation vaccination policies understanding disease both on national level comparison with international community. Methods Corona Immunitas is a research program coordinated, population-based, seroprevalence implemented by Swiss School Public Health (SSPH+). Over 28,340 participants, randomly selected age-stratified, some regional specificities...
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the serum an individual indicates previous infection or vaccination. However, it provides limited insight into protective nature this immune response. Neutralizing recognizing viral spike protein are more revealing, yet their measurement traditionally requires virus- and cell-based systems that costly, time-consuming, inflexible, potentially biohazardous. Here, we present a cell-free...
To examine longitudinal changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and to determine the clustering of children who were seropositive within school classes canton Zurich, Switzerland from June November 2020.Prospective cohort study.Switzerland had one highest second waves SARS-CoV-2 pandemic Europe autumn 2020. Keeping schools open provided a moderate high exposure environment study infections. Children randomly selected classes, stratified by...
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this had 0.54 to 0.74 log 10 increase (i.e., ~3.5-fold 5.5-fold increase) viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 other strains. Without treatment, advanced HIV—CD4 counts below 350 cells per cubic millimeter, long-term clinical consequences—is expected be reached, on average, 9 months after diagnosis for their thirties variant. Age, sex,...