A5046878109- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Disease Management Strategies
- SARS-CoV-2 and COVID-19 Research
- Physical Activity and Health
- COVID-19 Clinical Research Studies
- Health and Wellbeing Research
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Diabetes Management and Education
- Clinical practice guidelines implementation
- Mobile Health and mHealth Applications
- COVID-19 epidemiological studies
- Balance, Gait, and Falls Prevention
- Delphi Technique in Research
- Cerebral Palsy and Movement Disorders
- Smoking Behavior and Cessation
- Health and Medical Studies
- Long-Term Effects of COVID-19
- Health Promotion and Cardiovascular Prevention
- Single-cell and spatial transcriptomics
- Primary Care and Health Outcomes
- Health, psychology, and well-being
- COVID-19 Digital Contact Tracing
- Vaccine Coverage and Hesitancy
- School Health and Nursing Education
University of Zurich
2016-2025
Roche (Switzerland)
2020-2025
University Hospital of Zurich
2011-2024
Prevention Institute
2015-2024
University of Basel
2014-2024
Life Science Zurich
2023-2024
University of Fribourg
2024
University of Lausanne
2024
Sorbonne Université
2024
University of Bern
2024
The human intestinal microbiota is a crucial factor in the pathogenesis of various diseases, such as metabolic syndrome or inflammatory bowel disease (IBD). Yet, knowledge about role environmental factors smoking (which known to influence theses aforementioned states) on complex microbial composition sparse. We aimed investigate cessation 10 healthy subjects undergoing controlled cessation.During observational period 9 weeks repetitive stool samples were collected. Based abundance 16S rRNA...
<h3>Rationale</h3> Reduced physical activity (PA) in patients with COPD is associated a poor prognosis. Increasing PA key therapeutic target, but thus far few strategies have been found effective this patient group. <h3>Objectives</h3> To investigate the effectiveness of 12-week semiautomated telecoaching intervention on multicentre European randomised controlled trial. <h3>Methods</h3> 343 from six centres, encompassing wide spectrum disease severity, were randomly allocated to either usual...
Our aim was to comprehensively validate the 1-min sit-to-stand (STS) test in chronic obstructive pulmonary disease (COPD) patients and explore physiological response test. We used data from two longitudinal studies of COPD who completed inpatient rehabilitation programmes. collected STS test, 6-min walk (6MWT), health-related quality life, dyspnoea exercise cardiorespiratory at admission discharge. assessed learning effect, test–retest reliability, construct validity, responsiveness minimal...
To evaluate longer term symptoms and health outcomes associated with post-covid-19 condition within a cohort of individuals SARS-CoV-2 infection.Population based, longitudinal cohort.General population canton Zurich, Switzerland.1106 adults confirmed infection who were not vaccinated before 628 did have an infection.Trajectories self-reported status covid-19 related between months six, 12, 18, 24 after excess risk at six compared had no infection.22.9% (95% confidence interval 20.4% to...
Electronic nicotine-delivery systems - also called e-cigarettes are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these is needed.
Digital proximity tracing apps have been released to mitigate the transmission of SARS-CoV-2, virus known cause COVID-19. However, it remains unclear how acceptance and uptake these can be improved.
Abstract Objectives Seroprevalence studies to assess the spread of SARS-CoV-2 infection in general population and subgroups are key for evaluating mitigation vaccination policies understanding disease both on national level comparison with international community. Methods Corona Immunitas is a research program coordinated, population-based, seroprevalence implemented by Swiss School Public Health (SSPH+). Over 28,340 participants, randomly selected age-stratified, some regional specificities...
Abstract Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital outcomes (DMOs), such real-world gait speed or step count, show promise measures in many medical conditions. However, current research nascent fragmented by discipline. This scoping review maps existing evidence on the utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating...
Physical activity (PA) is of key importance for health among healthy persons and individuals with chronic obstructive pulmonary disease (COPD). PA has multiple dimensions that can be assessed quantified objectively using monitors. Moreover, as shown in the published literature, variable methodologies have been used to date quantify COPD, precluding clear comparisons outcomes across studies. The present paper aims provide a summary available literature rationale behind measured proposes...
Background The development of optimal strategies to treat impaired mobility related ageing and chronic disease requires better ways detect measure it. Digital health technology, including body worn sensors, has the potential directly accurately capture real-world mobility. Mobilise-D consists 34 partners from 13 countries who are working together jointly develop implement a digital assessment solution demonstrate that outcomes have provide better, safer, quicker way assess, monitor, predict...
Background Post COVID-19 condition (PCC) is an important complication of SARS-CoV-2 infection, affecting millions worldwide. This study aimed to evaluate the prevalence and severity post with novel variants after prior vaccination. Methods We used pooled data from 1350 SARS-CoV-2-infected individuals two representative population-based cohorts in Switzerland, diagnosed between Aug 5, 2020, Feb 25, 2022. descriptively analysed PCC, defined as presence frequency PCC-related symptoms six months...
BackgroundTumour-infiltrating CD8+ cytotoxic T cells confer favourable prognosis in colorectal cancer. The added prognostic value of other infiltrating immune is unclear and so we sought to investigate their two large clinical trial cohorts.MethodsWe used multiplex immunofluorescent staining tissue microarrays assess the densities CD8+, CD20+, FoxP3+, CD68+ intraepithelial intrastromal compartments from tumour samples patients with stage II–III cancer SCOT (ISRCTN59757862), which examined 3...
<h2>Abstract</h2><h3>Objective</h3> This study aimed to identify those comorbidities with greatest impact on patient-reported health status in patients chronic obstructive pulmonary disease (COPD) and develop a comorbidity index that reflects their combined impact. <h3>Study Design Setting</h3> We included 408 Swiss Dutch primary care COPD from the International Collaborative Effort Chronic Obstructive Lung Disease: Exacerbation Risk Index Cohorts (ICE COLD ERIC) this cross-sectional...
Recent technological advances have led to an increase in the production and availability of single-cell data. The ability integrate a set multi-technology measurements would allow identification biologically or clinically meaningful observations through unification perspectives afforded by each technology. In most cases, however, profiling technologies consume used cells thus pairwise correspondences between datasets are lost. Due sheer size can acquire, scalable algorithms that able...
Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read RNA sequencing (scRNA-seq) on clinical samples from three ovarian patients presenting with omental metastasis and increase PacBio depth to 12,000 reads per cell. Our approach captures 152,000 isoforms, which over 52,000 were not previously reported. Isoform-level analysis accounting for non-coding isoforms reveals 20% overestimation protein-coding gene...
Although physical activity is considered an important therapeutic target in chronic obstructive pulmonary disease (COPD), what "physical activity" means to COPD patients and how their perspective best measured poorly understood. We designed a conceptual framework, guiding the development content validation of two patient reported outcome (PRO) instruments on (PROactive PRO instruments). 116 from four European countries with diverse demographics phenotypes participated three consecutive...
Telecoaching approaches can enhance physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD). However, their effectiveness is likely to be influenced by intervention-specific characteristics.This study aimed assess the acceptability, actual usage, and feasibility of a complex PA telecoaching intervention from both patient coach perspectives link these intervention.We conducted mixed-methods based on completers group (N=159) included an (effective) 12-week...