A5058529999- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Smoking Behavior and Cessation
- Adrenal Hormones and Disorders
- Bone health and treatments
- Bone health and osteoporosis research
- Behavioral Health and Interventions
- Consumer Attitudes and Food Labeling
- Wireless Body Area Networks
- Vitamin D Research Studies
University of Bern
2019-2025
University Hospital of Bern
2022-2025
University of Fribourg
2024
University of Lausanne
2024
University of Basel
2024
University of Zurich
2024
Sorbonne Université
2024
Centre universitaire de médecine générale et santé publique, Lausanne
2024
Electronic nicotine-delivery systems - also called e-cigarettes are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these is needed.
People with psychiatric and substance use disorders are more likely to smoke less quit than smokers in the general population. We evaluated efficacy of e-cigarettes for abstinence from tobacco smoking people problems. analyzed data collected larger 'Efficacy, Safety, Toxicology ENDS as an Aid Smoking Cessation' (ESTxENDS) trial (n=1246): intervention group received e-liquids, plus standard-of-care cessation counseling (SOC) 6 months; control SOC a voucher. The primary outcome was...
Abstract Context Both thyroid dysfunction and levothyroxine (LT4) therapy have been associated with bone loss, but studies on the effect of LT4 for subclinical hypothyroidism (SHypo) yielded conflicting results. Objective To assess treatment mineral density (BMD), Trabecular Bone Score (TBS), turnover markers (BTMs) in older adults SHypo. Design Intervention Planned nested substudy double-blind placebo-controlled TRUST trial. Participants SHypo were randomized to dose titration versus...
Abstract Background Fatigue often triggers screening for and treatment of subclinical hypothyroidism. However, data on the impact levothyroxine fatigue is limited previous studies might not have captured all aspects fatigue. Method This study nested within randomized, placebo-controlled, multicenter TRUST trial, including community-dwelling participants aged ≥65 older, with persistent hypothyroidism (TSH 4.60–19.99 mIU/L, normal free thyroxine levels) from Switzerland Ireland. Interventions...
(Abstracted from N Engl J Med 2024;390:601–610 In a recent systematic review of randomized controlled trials (RCTs), e-cigarettes were found to be more effective for tobacco smoking cessation than nicotine replacement therapy (NRT). Yet, limited evidence exists on the safety and efficacy over standard-of-care counseling their ability relieve respiratory symptoms like cough phlegm compared with quitting cigarettes.
Abstract Background Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4). Objective To determine SHypo and positive LT4 than those negative antibodies. Methods We pooled individual participant data two RCTs,...