A5026639768- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Cerebral Palsy and Movement Disorders
- Pluripotent Stem Cells Research
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Pulmonary Hypertension Research and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Axon Guidance and Neuronal Signaling
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- RNA Research and Splicing
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2016-2025
Ferring Pharmaceuticals (Germany)
2023-2025
University of California, San Diego
2002-2024
University of Freiburg
2024
Comprehensive Cancer Center Erlangen
2023
Montanuniversität Leoben
2023
Fraunhofer Institute for Integrated Circuits
2022
Praxis
2007-2017
Philipps University of Marburg
2017
Abstract During development of the central nervous system, expression microtubule binding protein doublecortin (DCX) is associated with migration neuroblasts. In addition to this developmental role, DCX remains high within certain areas adult mammalian brain. These areas, mainly dentate gyrus and lateral ventricle wall in conjunction rostral migratory stream olfactory bulb, retain capacity generate new neurons into adulthood. Adult neurogenesis typically detected by incorporation...
Neurons and glia are generated throughout adulthood from proliferating cells in two regions of the rat brain, subventricular zone (SVZ) hippocampus. This study shows that exogenous basic fibroblast growth factor (FGF-2) epidermal (EGF) have differential site-specific effects on progenitor vivo. Both factors expanded SVZ population after 2 weeks intracerebroventricular administration, but only FGF-2 induced an increase number newborn cells, most prominently neurons, olfactory bulb, normal...
Abstract Progress in the field of neurogenesis is currently limited by lack tools enabling fast and quantitative analysis adult brain. Doublecortin (DCX) has recently been used as a marker for neurogenesis. However, it was not clear whether DCX could be to assess modulations occurring rate mammalian central nervous system following lesioning or stimulatory factors. Using two paradigms increasing levels (physical activity epileptic seizures), we demonstrate that quantification DCX‐expressing...
Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus adult mice. These stimuli are also known improve performance hippocampus-dependent learning tasks, but it is unclear whether their effects on exclusive hippocampal formation. In this study, we housed mice under three conditions (enriched environment, wheel running standard housing), analysed proliferation lateral ventricle wall cell olfactory bulb...
The existence of multipotent progenitor populations in the adult forebrain has been widely studied. To extend this knowledge to spinal cord we have examined proliferation, distribution, and phenotypic fate dividing cells rat cord. Bromodeoxyuridine (BrdU) was used label 13- 14-week-old, intact Fischer rats. Single daily injections BrdU were administered over a 12 d period. Animals killed either 1 or 4 weeks after last injection BrdU. We observed frequent cell division throughout rodent cord,...
The current view regarding human long-term memory as an active process of encoding and retrieval includes a highly specific learning-induced functional plasticity in network multiple systems. Voxel-based morphometry was used to detect possible structural brain changes associated with learning. Magnetic resonance images were obtained at three different time points while medical students learned for their examination. During the learning period, gray matter increased significantly posterior...
Abstract In the adult rat olfactory bulb, neurons are continually generated from progenitors that reside in lateral ventricle wall. This study investigates long‐term survival and cell death of newly cells within bulb. After injecting rats at 2 months age with 5‐bromodeoxyuridine (BrdU), were quantified over a period 19 months. A peak BrdU‐positive was reached bulb 1 month after BrdU injection, when all new have finished migrating Thereafter, reduction to about 50% observed it confirmed by...
Hypoxia as well global and focal ischemia are strong activators of neurogenesis in the adult mammalian central nervous system. Here we show that hypoxia‐inducible vascular endothelial growth factor (VEGF) its receptor VEGFR‐2/Flk‐1 expressed clonally‐derived rat neural stem cells vitro. VEGF stimulated expansion whereas blockade VEGFR‐2/Flk‐1‐kinase activity reduced cell expansion. was also infused into lateral ventricle to study changes wall, olfactory bulb hippocampus. Using a low dose...
Distinct gait characteristics like short steps and shuffling are prototypical signs commonly observed in Parkinson's disease. Routinely assessed by observation through clinicians, is rated as part of categorical clinical scores. There an increasing need to provide quantitative measurements gait, e.g. detailed information about disease progression. Recently, we developed a wearable sensor-based analysis system diagnostic tool that objectively assesses parameter without the having specialized...
The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson disease dementia with Lewy bodies (DLB). Emerging evidence suggests that ALP influences SNCA release, but underlying cellular mechanisms are not well understood. Several studies identified exosome/extracellular vesicle (EV) fractions. EVs generated multivesicular body compartment either released upon its fusion plasma...
In Parkinson's disease and dementia with Lewy bodies, α-synuclein aggregates to form oligomers fibrils; however, the precise nature of toxic species remains unclear. A number synthetic mutations were recently created (E57K E35K) that produce preferentially increase α-synuclein-mediated toxicity. We have shown acute lentiviral expression E57K leads degeneration dopaminergic neurons; effects chronic oligomer-prone in synapses throughout brain not been investigated. Such a study could provide...
Motor impairments are the prerequisite for diagnosis in Parkinson's disease (PD). The cardinal symptoms (bradykinesia, rigor, tremor, and postural instability) used staging assessment of progression. They serve as primary outcome measures clinical studies aiming at symptomatic modifying interventions. One major caveat scores such Unified Parkinson Disease Rating Scale (UPDRS) or Hoehn&Yahr (H&Y) is its rater time-of-assessment dependency. Thus, we aimed to objectively automatically classify...
SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating nonaggregating SNCA species are degraded by the autophagy-lysosomal pathway (ALP). Previously, we have shown that ALP is not only responsible for degradation but also involved intracellular process of SNCA. An additional extracellular pathology substantiating prion-like propagation hypothesis has been suggested since released spreading throughout neural...
Significance α-Synuclein (α-Syn) aggregation underlies neurodegeneration in synucleinopathies. However, the nature of α-Syn aggregates and their toxic mechanisms human pathology remains elusive. Here, we delineate a role oligomeric for axonal integrity neuronal models oligomers disrupt anterograde transport mitochondria by causing subcellular changes transport-regulating proteins energy deficits. An increase neurons finally results synaptic degeneration. Together, our data provide...
It has been proposed that targeted treatments should be combined for patients with idiopathic pulmonary arterial hypertension (IPAH) responding insufficiently to monotherapy. This study followed the clinical course of nine severe IPAH, in whom endothelin receptor antagonist bosentan caused transient improvement, eventually by a decline exercise tolerance, who received adjunct treatment phospodiesterase-5-inhibitor sildenafil. Measurements included 6-min walk distance (6MWD) and...
Abstract Adult neurogenesis has been shown to be regulated by a multitude of extracellular cues, including hormones, growth factors, and neurotransmitters. The cholinergic system the basal forebrain is one key transmitter systems for learning memory. Because adult implicated in cognitive performance, present work aims at defining role input using an immunotoxic lesion approach. immunotoxin 192IgG‐saporin was infused into lateral ventricle rats selectively neurons (CBF), which project two...
Abstract The main rationale for cell‐based therapies following spinal cord injury are: (i) replacement of degenerated parenchyma by an axon growth supporting scaffold; (ii) remyelination regenerating axons; and (iii), local delivery promoting molecules. A potential source to meet these requirements is adult neural progenitor cells, which were examined in the present study. Fibroblast factor 2‐responsive cord‐derived syngenic cells either genetically modified vitro express green fluorescent...