A5080409608- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Neuroscience, Education and Cognitive Function
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Genetics and Neurodevelopmental Disorders
- Zebrafish Biomedical Research Applications
- Pluripotent Stem Cells Research
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Neural dynamics and brain function
- Diet and metabolism studies
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Functional Brain Connectivity Studies
German Center for Neurodegenerative Diseases
2016-2025
TU Dresden
2016-2025
Berlin-Brandenburger Centrum für Regenerative Therapien
2007-2016
Excell Research (United States)
2011
Max Delbrück Center
2001-2010
Charité - Universitätsmedizin Berlin
2002-2009
Max Planck Society
2009
Deutsche Forschungsgemeinschaft
2008
Klinik und Poliklinik für Neurologie
2008
GTx (United States)
2008
Neurons and glia are generated throughout adulthood from proliferating cells in two regions of the rat brain, subventricular zone (SVZ) hippocampus. This study shows that exogenous basic fibroblast growth factor (FGF-2) epidermal (EGF) have differential site-specific effects on progenitor vivo. Both factors expanded SVZ population after 2 weeks intracerebroventricular administration, but only FGF-2 induced an increase number newborn cells, most prominently neurons, olfactory bulb, normal...
We demonstrate here that under physiological conditions neurogenesis continues to occur in the dentate gyrus of senescent mice and can be stimulated by living an enriched environment. Neurogenesis was investigated confocal microscopy three-channel immunofluorescent staining for proliferation marker bromodeoxyuridine (BrdU) neuronal glial markers. Quantification performed with unbiased stereological counting techniques. decreased increasing age. Stimulation adult aged switching from standard...
New neurons are continually generated in the adult hippocampus, but important question, whether neurogenesis is transient or leads to lasting presence of new neurons, has not yet been answered. Dividing cells were labeled with bromodeoxyuridine (BrdU) and investigated by means immunofluorescence confocal microscopy at several time-points 1 day 11 months thereafter. BrdU-labeled remained stable number their relative position granule cell layer over least months. This finding implies that...
Abstract Neurons are continually born from endogenous stem cells and added to the dentate gyrus throughout life, but adult hippocampal neurogenesis declines precipitously with age. Short‐term exposure an enriched environment leads a striking increase in new neurons, along substantial improvement behavioral performance. Could this plastic response be relevant for explaining beneficial effects of leading “an active life” on brain function pathology? Adult mice living age 10 20 months was...
Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus adult mice. These stimuli are also known improve performance hippocampus-dependent learning tasks, but it is unclear whether their effects on exclusive hippocampal formation. In this study, we housed mice under three conditions (enriched environment, wheel running standard housing), analysed proliferation lateral ventricle wall cell olfactory bulb...
The existence of multipotent progenitor populations in the adult forebrain has been widely studied. To extend this knowledge to spinal cord we have examined proliferation, distribution, and phenotypic fate dividing cells rat cord. Bromodeoxyuridine (BrdU) was used label 13- 14-week-old, intact Fischer rats. Single daily injections BrdU were administered over a 12 d period. Animals killed either 1 or 4 weeks after last injection BrdU. We observed frequent cell division throughout rodent cord,...
The current view regarding human long-term memory as an active process of encoding and retrieval includes a highly specific learning-induced functional plasticity in network multiple systems. Voxel-based morphometry was used to detect possible structural brain changes associated with learning. Magnetic resonance images were obtained at three different time points while medical students learned for their examination. During the learning period, gray matter increased significantly posterior...
To address genetic influences on hippocampal neurogenesis in adult mice, we compared C57BL/6, BALB/c, CD1(ICR), and 129Sv/J mice to examine proliferation, survival, differentiation of newborn cells the dentate gyrus. Proliferation was highest C57BL/6; survival rate CD1. In all strains ≈60% surviving had a neuronal phenotype, but 129/SvJ produced more astrocytes. Over 6 days C57BL/6 0.36% their total granule cell number 239,000 as new neurons, BALB/c 0.30% 242,000, CD1 (ICR) 0.32% 351,000,...
Abstract To study how adult hippocampal neurogenesis might originate from the proliferation of stem or progenitor cells in vivo, we have used transgenic mice expressing green fluorescent protein (GFP) under nestin promoter to identify these cells. Having described an astrocyte‐like type 1 cell with low proliferative activity, a characteristic morphology, vascular end feet, and passive electrophysiological properties, focused here on large population nestin‐GFP‐expressing 2 cells, which lack...
Essentially all knowledge about adult hippocampal neurogenesis in humans still comes from one seminal study by Eriksson et al. 1998, although several others have provided suggestive findings. But only little information has been available how far the situation animal models would reflect conditions and aging human brain. We therefore here mapped numerous features associated with rodents samples hippocampus across entire lifespan. Such data not offer proof of humans, because it is based on...
Despite enormous progress in the past few years specific contribution of newly born granule cells to function adult hippocampus is still not clear. We hypothesized that order solve this question particular attention has be paid design, analysis, and interpretation learning test used. thus designed a behavioral experiment along hypotheses derived from computational model predicting new neurons might particularly relevant for conditions, which novel aspects arise familiar situations, putting...
Brain plasticity as a neurobiological reflection of individuality is difficult to capture in animal models. Inspired by behavioral-genetic investigations human monozygotic twins reared together, we obtained dense longitudinal activity data on 40 inbred mice living one large enriched environment. The exploratory the diverged over time, resulting increasing individual differences with advancing age. Individual cumulative roaming entropy, indicating active coverage territory, correlated...